Thymus-dependent lymphocyte antigen epitope peptides of primary liver cancer related antigens and application thereof
A primary liver cancer, antigen epitope technology, applied in the field of medical immunology and oncology, can solve the problems of limiting personalized detection and limiting the role of liver cancer-specific T cells
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[0079] Embodiment 1: HLA-A0201, HLA-A1101, HLA-A2402, HLA-A3101, HLA-A0206, HLA-A0207, HLA-A3303, HLA-A3001, HLA-A0203, HLA-A1102, HLA-A0301, HLA-A0101, HLA-A2601 molecule-restricted liver cancer-associated antigen T cell epitope, the sequence is screened and identified through the following steps:
[0080] 1Online virtual prediction of dominant T cell epitope peptides of three liver cancer-associated antigens restricted by 13 HLA-A molecules
[0081]Three liver cancer-associated antigenic proteins were selected: alpha-fetoprotein (AFP), glypican-3 (GPC3), and Golgi transmembrane glycoprotein 73 (GP73), and their amino acid sequences were obtained by searching the UniProt global protein resource database , select the most studied standard sequence; and then use six commonly used epitope peptide prediction databases such as SYFPEITHI, BIMAS, SVMHC, IEDB, NETMHC, and EPIJEN to make HLA-A0201, HLA-A1101, HLA-A2402, HLA-A3101, HLA- A0206, HLA-A0207, HLA-A3303, HLA-A3001, HLA-A020...
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