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Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine

A technology of synergistic composition and tecanine, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems such as no detection of tecanine

Pending Publication Date: 2020-05-01
ORTHO NUTRA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Interestingly, tecanin was not detected at all in the more traditional tea strains

Method used

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  • Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine
  • Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine
  • Theacrine-based supplement and method of use thereof in a synergistic combination with caffeine

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0070] To examine the beneficial experimental effects and psychometric properties of tecanin supplementation in healthy subjects, optimal dosing and potential cumulative effects were studied in healthy human cohorts using a 7-day subacute repeated dosing regimen, and to obtain For preliminary data on different biomarkers of safety and tolerability, perform an experiment.

[0071] 15 healthy subjects (mean ± SD age, height, weight, BMI: 28.3 ± 6.1y, 175.7 ± 11.5cm, 89.8 ± 21.7kg, 29.1 ± 4.7) ingested 200mg of TeaCrine TM (Compound Solutions, Carlsbad, CA) (TC) or placebo (PLA). Anchored VAS questionnaires were used to examine changes in various aspects of physical and mental energy and performance; side effect profiles, hemodynamics, and biochemical markers of safety were also collected during the 3-hour post-dose period. A subgroup comprising 6 subjects underwent a separate 7-day open-label repeat dose study comparing 100 mg, 200 mg and 400 mg of TC.

[0072] The trial was a...

example 2

[0087] Evaluation of the drug-drug interaction potential between tecanine and caffeine in humans

[0088] Tecanine pharmacokinetics have not been systematically characterized in humans. Therefore, it was an aim of the present study, inter alia, to determine the pharmacokinetics and dose-linearity of tecanin after oral administration in humans. Another aim of this study was to determine whether caffeine altered tecanine pharmacokinetics and / or pharmacodynamics when the two ingredients were ingested together.

[0089] Eight healthy non-smokers (including 4 males and 4 females) were recruited for the experiment. Test subjects regularly consumed stimulants (ie, caffeine, 50-400 mg / day) with beverages or nutritional supplements. The same test subjects had no history of adverse reactions to caffeine or other stimulants.

[0090] Study Design and Procedures

[0091] The study was a randomized, double-blind, 4-group crossover design in which each subject received 4 treatments cons...

example 3

[0116] Example 3. Improvement of subjective sensation, cognitive performance and hemodynamics

[0117] In a clinical study, the effects of tecanine, caffeine, or their combination administered alone on subjective sensation, cognitive performance, and hemodynamics in men and women were examined. In said study, 24 men and 26 women ingested a placebo, 25 mg tecanine, 125 mg tecanine, 150 mg caffeine or a combination of 125 mg tecanine and 150 mg caffeine on five different occasions , with an interval of about one week. Subjects rated their subjective perception using a 10cm visual analog scale at 30 minutes, 1 hour, 2 hours, 3 hours, 4 hours, and 5 hours after ingestion, and at baseline and 2 and 4 hours after ingestion Cognitive Performance Connected Test (TMT). Subjective perceptions of attention, concentration and a sense of energy improved in all active treatments. More favorable scores were generally associated with caffeine and tecanine / caffeine combination treatments. ...

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Abstract

A human dietary supplement comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theacrine-containing supplement include improvement of at least one of mood, energy, focus, concentration or sexual desire or a reduction of at least one of anxiety or fatigue. A synergistic composition comprises co-administration of theacrine and caffeine, wherein theco-administered caffeine reduces theacrine oral clearance (CL / F) and oral volume of distribution (Vd / F). In addition, the co-administered caffeine increases area under the plasma concentration time curve (AUC) of theacrine, and increases theacrine maximum plasma concentration (Cmax) in comparison with the corresponding pharmacokinetic parameters when theacrine is administered alone.

Description

[0001] This application claims the benefit of US Patent Application Serial No. 15 / 600,371, filed May 19, 2017, which is hereby incorporated by reference. technical field [0002] The present invention relates to systems and methods for using theacrine alone or in combination to provide physiological benefits. More specifically, the present invention relates to tecanine and other naturally occurring compounds, whether produced synthetically or harvested from natural sources, and the use of these compounds to provide physiological benefits that can be determined according to the concentration of tecanine and the presence or absence of potentiators and antagonists. Background technique [0003] Tea is one of the most widely consumed products in the world. Tea and the different varieties of tea have been intensively studied. Many epidemiological and preclinical studies have shown that tea drinking can reduce the risk of cancer and cardiovascular disease. Tecanin, a purine alk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61P21/00
CPCA61K31/522A61P21/00
Inventor 赫克托·L·洛佩兹肖恩·威尔斯蒂姆·N·齐格恩福斯
Owner ORTHO NUTRA
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