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An Anti-Inflammatory Restorative Mouthwash

A technology of mouthwash and normal saline, applied in the direction of anti-inflammatory agents, digestive system, inorganic non-active ingredients, etc., can solve problems such as poor nutritional status, affecting ulcer healing, delaying disease, etc., to improve nutritional intake status, weaken genetic Toxicity, Pain Relief Effect

Active Publication Date: 2021-01-26
潘肖芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the existence of mucosal ulcers, symptoms such as pain and eating pain will seriously affect the life treatment, and the pain will affect eating and poor nutritional status, which will delay the disease and affect the healing of the ulcer, resulting in a vicious circle

Method used

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  • An Anti-Inflammatory Restorative Mouthwash
  • An Anti-Inflammatory Restorative Mouthwash
  • An Anti-Inflammatory Restorative Mouthwash

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Prepare mouthwash, described mouthwash is made up of following formula ratio:

[0028] Metronidazole 1g, vitamin B12 25mg, dexamethasone 5mg, clindin D10mg, normal saline 200ml, drug dissolution adjuvant.

[0029] Described clindin D, its molecular formula is: C 21 h 28 o 5 . Its structural formula is as follows:

[0030]

[0031] According to the conventional method, dissolve all the above-mentioned ingredients into a mouthwash for later use.

Embodiment 2

[0036] Example 2 Genotoxicity Detection

[0037] Garlic grows roots in distilled water, and when the roots grow to 1-3 cm, choose garlic cloves with good root tip growth. Distilled water was set as a control group, and the mouthwash solutions of Example 1 and Comparative 1 were used as treatment groups. The mouthwash solutions of the control group and the treatment group were treated for 12 and 24 hours, respectively. Cut the root tip, fix it with Carnot's fixative solution for 24 hours, infiltrate it in 70% ethanol, and store it at 4°C. Rinse 3 times with distilled water, soak in 1mol / L HCl 60°C constant temperature water bath for 8 minutes, wash with water and place on a glass slide, cut off the root tip with a scalpel about 0.3-0.5cm in length, stain with phenol fuchsin for 8 minutes, and press into pieces. Microscopic examination.

[0038] Three slices were randomly selected for each treatment group, 1000 cells were counted for each root tip, and a total of 3000 cells w...

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Abstract

The invention discloses an anti-inflammatory and repairing mouthwash, the formula of which is as follows: in parts by weight, 5-20 parts of metronidazole, 0.2-0.5 parts of vitamin B12, 0.03-0.1 parts of dexamethasone, 0.1 parts of clindrol D, 2000 parts of normal saline, and other pharmaceutically acceptable adjuvants. Preferably, the mouthwash also contains 0.5 g of lidocaine, which is used for patients with severe pain. Through reasonable proportioning, this formula can give full play to the anti-inflammatory effect of metronidazole, the analgesic effect of lidocaine, the detumescence effect of dexamethasone, and the repairing effect of vitamin B12. By gargling before and after meals every day, it can achieve pain relief, anti-inflammatory and repairing effects. In addition, the introduction of non-cytotoxic accelin D from natural plants can greatly reduce the genotoxicity of metronidazole, making the mouthwash of the present invention non-toxic, healthy, and can be used for a long time, especially suitable for tumor patients.

Description

technical field [0001] The invention relates to an anti-inflammatory and repairing mouthwash, which belongs to the field of new biotechnology daily chemicals. Background technique [0002] At present, there are two types of mouthwash formulations commonly used in the market. The first category is mouthwash formulations for health care, which are mainly Chinese patent medicine formulations. The main components are menthol, thymol, salicylic acid, citric acid, castor oil, Western Pyridamide, etc., mainly play the role of oral cavity cleaning, inhibiting dental plaque, inhibiting bacterial growth, etc., and are used for various gingivitis, pharyngitis or oral odor. The second category is medicinal mouthwash formulations, the main ingredients of which are antibiotics. Metronidazole mouthwashes are common on the market. The main function is anti-inflammatory, and it is used for oral diseases such as gingivitis and pharyngitis. There is still no mouthwash specifically for oral ul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/714A61K31/341A61K9/08A61P29/00A61P1/02A61K31/167A61K31/4164A61K31/573
CPCA61K9/0056A61K31/167A61K31/341A61K31/4164A61K31/573A61K31/714A61K47/02A61P1/02A61P29/00A61K2300/00
Inventor 潘肖芬
Owner 潘肖芬
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