Oral and skin compositions

一种组合物、皮肤的技术，应用在口腔用和皮肤用组合物领域，能够解决形成龋齿、口腔易偏酸性、过度研磨牙齿等问题，达到预防龋齿的产生、提高清洗效果、防止牙齿磨损的效果

Active Publication Date: 2013-04-03
JAPAN ADVANCED MEDICAL RES ASSOC CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is a problem that, based on the characteristics of the abrasives added, brushing for a long time will excessively grind the teeth, causing the enamel to peel off, and instead it becomes easy to become caries
Furthermore, the present inventors have found that if the pH in the oral cavity is acidic, the enamel will dissolve and caries will easily occur (the pH at which the enamel starts to dissolve is about 5.5), but the pH of drinking water (pH 5 to 7) and food is absolutely Most of them are acidic, so there is a problem that an acidic environment tends to be formed in the mouth, and caries will form even if you brush your teeth

Method used

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  • Oral and skin compositions
  • Oral and skin compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Experimental examples are shown below to specifically describe the present invention. However, the scope of the present invention is not limited thereto.

[0056]In Example 1, according to the formulations shown in Table 1 and Table 2, the oral gel of the inventive example was prepared by a conventional method, and periodontitis, stomatitis, and side effects were evaluated by the evaluation methods shown below. In addition, based on the formulations shown in Table 3 and Table 4, the oral gel of Comparative Example was prepared by a conventional method, and the same evaluation was performed. The usage-amount is shown by mass%.

[0057] [Table 1]

[0058]

[0059] [Table 2]

[0060] Invention example

[0061] [table 3]

[0062] comparative example

[0063] [Table 4]

[0064] comparative example

[0065] Evaluation method

[0066] For each inventive example and comparative example, let 10 males and 10 females total 20 subjects brush t...

Embodiment 2

[0082] In Example 2, according to the prescriptions shown in the above Table 1 and Table 2, the anti-dermatitis gel and anti-fungal gel of the inventive example were prepared by a conventional method, and the dermatitis, white ringworm and side effects were evaluated by the evaluation method shown below . In addition, the antidermatitis gel and antifungal gel of Comparative Example were prepared by conventional methods based on the formulations shown in Table 3 and Table 4 above, and the same evaluation was performed. The usage-amount is shown by mass%.

[0083] Evaluation method

[0084] For each inventive example and comparative example, 10 test subjects, 5 males and 5 females in total, washed the affected area and its surroundings with cotton or the like, and applied 1 g of the above-mentioned composition to the affected area with fingers for 1 week. As the test results, the affected area was observed and the number of subjects was determined according to the following cl...

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Abstract

A composition for oral cavity and skin which contains an antibacterial agent and does not have adverse side effects due to steroids, is provided. The composition contains 0.01 to 4.5% by mass of at least one selected from the group consisting of an antibacterial agent, an antiviral agent, an anti-HIV agent, a non-nucleic acid-based reverse transcriptase inhibitor, an anticancer agent for external use and a disinfectant; 0.01 to 4.5% by mass of a non-steroidal anti-inflammatory agent; 0.001 to 4.5% by mass of a steroidal anti-inflammatory agent; and 0.001 to 10% by mass of a highly water-absorbent polymer or a cellulose derivative.

Description

technical field [0001] The present invention relates to a composition for oral cavity and skin, and more specifically, to a composition for skin and oral cavity containing at least one antibacterial agent, etc. It is a non-steroidal anti-inflammatory agent, so it has no side effects and is excellent in the treatment of periodontal disease and dermatitis. Background technique [0002] It is known that steroids can strongly inhibit inflammation by inhibiting the function of lymphocytes, or inhibiting inflammatory peptides, and inhibiting the proliferation of fibroblasts, so they are widely used in the treatment of inflammatory diseases. The most powerful anti-inflammatory agent for oral diseases and dermatitis. In particular, corticosteroids are the most widely used anti-inflammatory drugs for both acute and chronic inflammation. [0003] However, steroids are known to have various side effects. For example, when used in the oral cavity, there are side effects such as pain ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K47/04A61K47/32A61K47/36A61K47/38A61P1/02A61P17/00A61P43/00
CPCA61K47/02A61K9/0063A61K45/06A61K47/38A61K9/0014A61K33/30A61K47/32A61P1/02A61P17/00A61P29/00A61P31/04A61P43/00A61K2300/00
Inventor 野田哲
Owner JAPAN ADVANCED MEDICAL RES ASSOC CO LTD
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