Traditional Chinese medicine composition for treating Alzheimer's disease kidney deficiency and preparation method and application thereof
A technology for Alzheimer's disease and a composition, which is applied in the field of traditional Chinese medicine and can solve problems such as side effects and lack of overall regulating effect.
Active Publication Date: 2020-06-19
云南典润洋科技有限公司
View PDF2 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0011] Data show that many drugs are effective for Alzheimer's kidney deficiency, such as vitamin B6 (Kalani A, CHAcurvedi P, Kalani K, et al. A high methionine low folate and vitamin B6 / B12containing diet can be associated with memory loss by epigenetic silencing of netrin -1[J].Neural Regen Res, 2019,14(7):1247-1254.), anti-Aβ drugs (Liu D, Li W, Jiang X, et al.Using near-infrared enhanced thermozyme and scFv dualconjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer's disease[J]. Theranostics, 2019, 9(8): 2268-2281.), anti-neuronal apoptosis drugs, estrogen (Lai YJ, Zhu BL, Sun F, et al. Estrogen receptorα promotes Cav1.2ubiquitination and degradation in neuronal cells and in APP / PS1mice[J]. Aging Cell, 2019, 18(4): e12961.), new nano-selenium, antioxidants (Sharma R, Kuca K, Nepovimova E, et al .Traditional Ayurvedic and herbal remedies for Alzheimer's disease: from bench to bedside[J].Expert Rev Neurother, 2019, 19(5):359-374.), memantine, etc., however, these drugs often have certain side effects and No global regulation
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0089] Example 1 Preparation of a Chinese medicinal composition for the treatment of senile dementia kidney deficiency
[0090] The traditional Chinese medicine composition is composed of the following raw materials by weight: 100g of corn, 18g of raw keel, 30g of Eclipta, 12g of Luodeda, 23g of Verbena, 12g of corrugated seed, 4g of acute seed and 6g of Lingxiaohua.
Embodiment 2
[0091] Embodiment 2 Preparation of a Chinese medicine composition for treating senile dementia kidney deficiency
[0092] The traditional Chinese medicine composition is composed of the following raw materials by weight: 80g of corn, 20g of raw keel, 25g of eclipta, 15g of Luodeda, 20g of verbena, 15g of corrugated seed, 3g of zizizi and 5g of Lingxiaohua.
Embodiment 3
[0093] Embodiment 3 A kind of preparation of Chinese medicine composition for the treatment of senile dementia kidney deficiency
[0094] The traditional Chinese medicine composition is composed of the following raw materials by weight: 120g of corn, 15g of raw keel, 32g of Eclipta, 10g of Luodeda, 25g of verbena, 10g of corrugated seed, 2g of succulent and 10g of Lingxiaohua.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention discloses a traditional Chinese medicine composition for treating Alzheimer's disease kidney deficiency and a preparation method and application thereof. The traditional Chinese medicinecomposition is prepared from the following raw materials in parts by weight: 80 to 120 parts of millet, 15 to 20 parts of crude dragon bone, 25 to 35 parts of herba ecliptae, 10 to 15 parts of centella asiatica, 20 to 25 parts of herba verbenae, 10 to 15 parts of concha arcae, 2 to 5 parts of garden balsam and 5 to 10 parts of trumpet-creeper flowers. Experimental results show that the composition can be used for improving the learning and memory capabilities of the Alzheimer's disease kidney deficiency clean-grade Kunming mice, can also improve the hippocampus beta-amyloid precursor proteinrelated protein, hippocampus inflammatory mediator and hippocampus antioxidant capacity of the Alzheimer's disease kidney deficiency clean-grade Kunming mice, can improve the expression of hippocampusacetylcholine metabolic enzyme and beta-amyloid transporter gene and protein in brain tissue of the clean-grade Kunming mice with Alzheimer's disease kidney deficiency, and has no influence on the organ index and weight of the mouse, which indicates that the traditional Chinese medicine composition is effective in treating Alzheimer's disease kidney deficiency and has no side effect.
Description
technical field [0001] The invention relates to a traditional Chinese medicine composition and its preparation method and application, in particular to a traditional Chinese medicine composition for treating senile dementia kidney deficiency and its preparation method and application. The invention belongs to the technical field of traditional Chinese medicine. Background technique [0002] At present, Alzheimer's disease is a common disease of the elderly, including Alzheimer's disease, vascular dementia, Lewy body dementia and frontotemporal dementia, etc. , Aβ) deposition to form senile plaques (Sochocka M, Ochnik M, Sobczyński M, et al. New therapeutic targeting of Alzheimer's disease with the potential use of proline-richpolypeptide complex to modulate an innate immune response preliminary study[J].J Neuroinflammation, 2019 , 16(1): 137.; Mizuta K, Saneyoshi T. Amyloid-βDependent Neuronal Circuit Rearrangement in Presymptomatic Alzheimer's Disease [J]. Biol Psychiatry,...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/899A61P25/28A61K35/02A61K35/618
CPCA61K36/899A61K35/02A61K36/28A61K36/35A61K36/85A61K35/618A61K36/185A61P25/28A61K2236/331A61K2236/39A61K2300/00
Inventor费洪新
Owner云南典润洋科技有限公司