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Device and method for mineralization of tissue engineering scaffold

A technology of tissue engineering scaffold and support frame, which is applied in the field of mineralization of tissue engineering scaffold and mineralization device of tissue engineering scaffold, which can solve the problems that the calcified tissue interface has not been reported, and achieve the effect of precise mineralization and simple operation

Active Publication Date: 2020-07-28
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Nonetheless, successful in vitro formation of continuous, precise calcified tissue interfaces has not been reported

Method used

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  • Device and method for mineralization of tissue engineering scaffold
  • Device and method for mineralization of tissue engineering scaffold
  • Device and method for mineralization of tissue engineering scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Embodiment 1 A kind of tissue engineering scaffold mineralization device

[0083] like figure 1 As shown, the tissue engineering scaffold mineralization device contains an output micropump 1 for controlling the mineralization fluid; a syringe 2 for storing the mineralization fluid and outputting the mineralization fluid under the control of the micropump; Liquid mineralization tank3. The mineralization tank 3 is provided with a support frame 4 with a slope of about 30° (such as 25, 26, 27, 28, 29, 31, 32, 33, 34, 35, or any value in between) , for placing tissue engineering scaffolds. The tissue engineering scaffold mineralization device also includes a mineralization fluid delivery pipeline 5 , one end of which is connected to the output end of the syringe 2 , and the other end is connected to the lower part of the mineralization tank 3 . The support frame 4 is a plane.

Embodiment 2

[0084] Embodiment 2 A kind of tissue engineering scaffold mineralization device

[0085] like figure 2 In the tissue engineering scaffold mineralization device shown, one end of the mineralization liquid delivery pipeline 5 is connected to the output end of the syringe 2, and the other end extends into the mineralization tank 3, and other features are the same as in the first embodiment.

Embodiment 3

[0086] Embodiment 3 A kind of tissue engineering scaffold mineralization device

[0087] A tissue engineering support, the support frame 4 is a mesh surface, which can make the tissue engineering support directly contact with the mineralization solution more fully, and the mineralization is more complete, and the rest of the features are the same as in the first embodiment.

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Abstract

The invention belongs to the field of tissue engineering, and relates to a tissue engineering scaffold mineralization device and a tissue engineering scaffold gradient mineralization method. The tissue engineering scaffold mineralization device includes a micro pump, an injector and a mineralization tank, wherein the micro pump is used for controlling output of a mineralized liquid, the injector is used for storing the mineralized liquid and outputting the mineralized liquid under the control action of the micro pump, and the mineralization tank is used for receiving the mineralized liquid; and an inclined support bracket is arranged on the mineralization tank, and is used for placing a tissue engineering scaffold. Through the tissue engineering scaffold mineralization device, gradient mineralization can be performed on a bone-tendon interface scaffold automatically and accurately.

Description

technical field [0001] The present application belongs to the field of tissue engineering, and relates to a tissue engineering scaffold mineralization device and a tissue engineering scaffold mineralization method. Background technique [0002] The following content is only the applicant's knowledge of the relevant technical field, and does not necessarily constitute the prior art. [0003] Tissue engineering scaffolds refer to materials that can be combined with living tissue cells and can be implanted into different tissues of the organism, and can replace the functions of the tissue according to specific conditions. Interface tissue refers to the junction of different tissue types such as ligament to bone, tendon to bone and cartilage to bone. [0004] In recent years, interface tissue engineering is booming, and the core and difficult research includes the reconstruction of calcified layer structure (Seidi, Azadeh, et al. "Gradient biomaterials for soft-to-hard interfac...

Claims

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Application Information

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IPC IPC(8): A61F2/08A61L27/02A61L27/12A61L27/16A61L27/18A61L27/50
CPCA61F2/0811A61L27/12A61L27/16A61L27/025A61L27/18A61L27/50A61F2240/001A61L2400/12A61L2430/02A61L2430/10A61L2430/06C08L77/04C08L33/02
Inventor 吕红斌史强胡建中陈灿赵春风
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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