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System for evaluating prognosis of patient with spinal glioma based on peripheral blood cells

A glioma, prognostic technology, applied in the field of biomedicine, can solve the problems of large differences in the prognosis of diffuse spinal glioma and unclear prognostic factors of diffuse spinal glioma, and achieve rapid and accurate evaluation and detection. The effect of low operation complexity and simple acquisition process

Active Publication Date: 2020-08-14
BEIJING NEUROSURGICAL INST
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Problems solved by technology

In these limited studies, the prognosis of diffuse gliomas varied widely, with a median survival of only 10–14 months for some high-grade diffuse gliomas, and compared with that of diffuse gliomas. Prognostic factors remain unclear

Method used

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  • System for evaluating prognosis of patient with spinal glioma based on peripheral blood cells
  • System for evaluating prognosis of patient with spinal glioma based on peripheral blood cells
  • System for evaluating prognosis of patient with spinal glioma based on peripheral blood cells

Examples

Experimental program
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Embodiment 1

[0051] This embodiment is used to illustrate the establishment of the evaluation model of the present disclosure.

[0052] 88 cases of diffuse spinal glioma samples were collected using the operation in accordance with the standards of the medical ethics committee, and the pathological characteristics of each diffuse spinal glioma sample were judged. Among them, each patient who collects samples has obtained the consent of himself and his therapist before collecting samples, and has written certification materials. Diffuse spinal cord glioma was diagnosed by pathological diagnosis method, and the peripheral blood cell count index of each sample was detected and calculated by a blood cell analyzer. The prognosis of the diffuse spinal glioma sample was evaluated according to the survival period of the patients corresponding to the diffuse spinal glioma sample. The longer the survival period of the patient, the better the prognosis of the diffuse spinal glioma. The gender, age, ...

Embodiment 2

[0063] This embodiment is used to verify the evaluation model of the present disclosure

[0064] According to the method of Example 1, 88 samples of diffuse glioma were recollected, including 46 samples of lower grade glioma (WHO grade II / III) and 42 samples of WHO grade IV glioma. All diffuse spinal glioma samples were used as the first validation set, lower-grade spinal glioma samples (WHO grade II / III) were used as the second validation set, and WHO grade IV spinal glioma samples were used as the third validation set. Use a blood cell analyzer to detect and calculate the white blood cell count, neutrophil count, platelet count and lymphocyte count of each sample, and based on the above detection data, and use formula (2) to calculate the prognosis score of each sample respectively, the prognosis Samples with a score <3.85 were classified into the low-risk group, and samples with a prognostic score ≥3.85 were classified into the high-risk group. Each sample was followed up ...

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Abstract

The invention relates to a system for evaluating prognosis of a patient with spinal glioma based on peripheral blood cells. The system is characterized by comprising an input device, a computing device and an output device. The input device is used for inputting a plurality of peripheral blood cell counting units of an individual spinal glioma patient, and the plurality of peripheral blood cell counting units comprise a leukocyte counting unit, a neutrophil counting unit, a platelet counting unit and a lymphocyte counting unit. Through the above technical scheme, peripheral blood of a patientwith spinal glioma only needs to be collected, and the peripheral blood cell counting number in the peripheral blood is detected; the prognosis score of the patient can be calculated and output according to various blood cell counting numbers; the prognosis condition of the patient can be evaluated according to the prognosis score; the peripheral blood collection process is simple and rapid, and the detection operation complexity of the blood cell count in the peripheral blood is low, such that the prognosis condition of the spinal glioma patient can be simply, rapidly and accurately evaluated.

Description

technical field [0001] The present disclosure relates to the field of biomedical technology, in particular to a system for evaluating the prognosis of spinal cord glioma patients based on peripheral blood cells. Background technique [0002] Diffuse spinal glioma (WHO grade II-IV) is one of the most common malignant tumors in the spinal cord. Compared with brain gliomas caused by intracranial lesions, diffuse spinal gliomas are relatively rare, and only a small amount of spinal cord glioma tissue can be obtained during the operation of spinal cord gliomas. Knowledge of gliomas in the spinal cord has largely come from limited studies of a small number of cases. In these limited studies, the prognosis of diffuse gliomas varied widely, with a median survival of only 10–14 months for some high-grade diffuse gliomas, and compared with diffuse gliomas. Factors associated with prognosis remain unclear. [0003] The most common treatment for diffuse gliomas is maximal safe surgic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/10G01N21/84G16H50/20
CPCG01N15/10G01N21/84G16H50/20G01N2015/1006G01N2015/016G01N15/01
Inventor 柴睿超王永志贾文清庞波张耀武
Owner BEIJING NEUROSURGICAL INST
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