120 results about "PLT - Platelets" patented technology

The invention relates to the technical field of medical artificial intelligence, in particular to a vascular embolism risk prediction method based on big data analysis, and the method comprises the steps: collecting a pulse pressure fluctuation rate, a microcirculation resistance index and a platelet adhesion gradient through a multi-source sensor, and extracting dynamic physiological parameter time sequence features; constructing a hemodynamic finite element model based on CTA and VFI image data, and obtaining a vascular mechanical feature vector; deep coupling of the pulse pressure spectrum and the circumferential stress is achieved through dynamic time warping and convolution mapping, and a multi-modal risk feature set is generated; and performing cross-modal coding by using the double-branch graph neural network, and outputting an acute embolism probability and a three-dimensional risk thermodynamic diagram. According to the method, physiological, image and mechanical multi-dimensional information is fused, and the method has the advantages of being high in real-time performance, accurate in positioning and good in interpretability and is suitable for risk prediction and auxiliary diagnosis of clinical cardiovascular and cerebrovascular events.

Provided is a method for assisting in grasping the status of platelet activation, by developing a biomarker that more accurately reflects platelet activation in vivo, said method being usable in testing for thrombotic hemostatic diseases. The method for assisting in grasping the status of platelet activation comprises (1) measuring the concentration of soluble CLEC-2 and a platelet count in a sample obtained from a subject, and (2) calculating a value of [soluble CLEC-2 concentration] / [platelet count] by dividing the soluble CLEC-2 concentration by the platelet count. If desired, the method may further comprise (3) comparing the value with a value of [soluble CLEC-2 concentration] / [platelet count] obtained by using samples from healthy persons.

The invention discloses a hematology analyzer and a platelet numerical value measuring method, in the hematology analyzer, an analysis unit is used for receiving a pulse signal to generate a first image, receiving an optical signal to generate a second image, obtaining a platelet original numerical value based on the first image, obtaining an interference coefficient of a leukocyte fragment based on the second image, and obtaining the platelet numerical value based on the interference coefficient; and obtaining a platelet measurement value based on the platelet original value and the interference coefficient. Through the cooperation of the impedance module and the flow fluorescence module, the platelet original value in the blood cell sample and the interference coefficient of the leukocyte fragment are detected, and the accuracy of each step in the calculation process of the platelet measurement value is ensured. Meanwhile, the platelet measurement numerical value is calculated through the analysis unit based on the platelet original numerical value and the interference coefficient, so that the accuracy of the blood cell analyzer for measuring the platelet measurement numerical value is improved, the practicability of the blood cell analyzer is improved, and the use experience of a user on the blood cell analyzer is improved.

The invention provides a micro-fluidic chip for detecting platelet aggregation function, and relates to the technical field of platelet aggregation function detection.The micro-fluidic chip comprises a chip body, the chip body is provided with at least one group of detection parts, and each group of detection parts comprises a sample adding groove and at least one group of detection units; the detection unit comprises a coating runner and a reaction cavity; the inner wall of the coating flow channel is coated with an activating agent coating, and the length extending direction of the coating flow channel is inclined relative to the radial direction with the rotation center as the circle center, so that the proximal end and the distal end of the coating flow channel are located on different radial lines with the rotation center as the circle center respectively. Through the arrangement, local retention or dead zones are avoided, the detection efficiency is improved, the dissolution rate of the activator is effectively improved, the dissolution rate of an activator coating is more than 5 mu g / s, the activator is ensured to be fully dissolved, the error absolute value of the final concentration of the activator in a sample is less than 6%, the detection error is reduced, and the detection accuracy is improved.

A system includes: a dialysis machine configured to provide a dialysis treatment for a patient; at least one fluid line; a sensor disposed on the at least one fluid line, wherein the sensor is configured to obtain platelet measurements from fluid passing through the at least one fluid line; and a processing system configured to: receive the platelet measurements from the sensor; determine whether the platelet measurements are indicative of a risk of Heparin-induced thrombocytopenia (HIT) to the patient; and in response to determining that the platelet measurements are indicative of a risk of HIT to the patient, provide an alert to the patient and / or a clinician based on the platelet measurements.

The present invention provides a pharmaceutical composition for use in a method of treating pulmonary arterial hypertension (PAH). [Solution] A pharmaceutical composition for use in a method for treating pulmonary arterial hypertension (PAH) in a patient in need, comprising an ActRIIA fusion protein, wherein the ActRIIA fusion protein is (i) ActRIIA polypeptide containing a specific amino acid sequence, (ii) Fc domains containing an amino acid sequence that is at least 95% identical to a specific amino acid sequence, (iii) comprising a linker domain located between the ActRIIA polypeptide and the Fc domain, Herein, the ActRIIA fusion protein is administered in a first dose of 0.3 mg / kg and a second dose of 0.7 mg / kg, wherein the second dose is administered after confirming that the patient has an acceptable hemoglobin level and / or platelet count, in a pharmaceutical composition.

The application discloses a platelet performance index evaluation method and device. The method comprises the following steps: collecting platelets to be detected; collecting cloud and mist characteristic data of the platelets to be detected by using an image and video device, wherein the cloud and mist characteristic data comprises cloud and mist characteristic image data and / or cloud and mist characteristic video data; and evaluating platelet performance indexes by using the cloud and mist characteristic data of the platelets to be detected. The application can accurately, quickly and at low cost detect platelet performance indexes, and solves problems of long time consumption, high cost and large result error of a traditional platelet performance detection method.

The utility model relates to the technical field of medical instruments, in particular to a platelet-rich plasma raw material extractor which comprises a blood sampling outer barrel, a blood sampling movable barrel inserted into an inner cavity of the blood sampling outer barrel in a sliding mode in the axial direction, an injection inner barrel detachably connected to an inner cavity of the blood sampling movable barrel and an injection push rod inserted into an inner cavity of the injection inner barrel in a sliding mode in the axial direction. The head of the blood sampling outer cylinder is detachably connected with a sealing cover for blocking a needle hole of the blood sampling outer cylinder, the head of the blood sampling movable cylinder is provided with a blood sampling piston which is in sealed sliding connection with the inner circumferential wall of the blood sampling outer cylinder, and the head of the injection push rod is provided with an injection piston which is in sealed sliding connection with the inner circumferential wall of the injection inner cylinder; a through hole is formed in the head of the blood sampling movable cylinder, the needle hole of the blood sampling outer cylinder, the through hole and the needle hole of the injection inner cylinder jointly form a fluid communication channel, and a fixing piece used for limiting relative sliding of the injection push rod and the injection inner cylinder is detachably connected between the injection push rod and the injection inner cylinder. The method has the effect of accurately controlling the extraction amount of the platelet-rich plasma.

The present application relates to the technical field of platelet concentration, in particular to a platelet concentration method and system based on gravity sedimentation, comprising the following steps: obtaining sedimentation path unit parameters and collecting speed difference values, screening staggered difference point and judging acceleration trend, extracting decreasing curvature difference to determine boundary, adjusting inclination angle to collect speed change rate and screen falling path, calculating vector to establish extraction path to obtain secondary concentration data. In the present application, by extracting sedimentation speed difference value and acceleration change trend, the layered boundary area is identified, the positioning accuracy of the concentration limit is improved, based on the inclination disturbance induced dynamic response, the path unit with outstanding speed rising rate is screened, the perception ability and layered clarity of the limit area are enhanced, with the help of speed vector direction and center position calculation, a stable linear extraction path is constructed, efficient recovery and focused extraction of trace platelets are realized, the precision, stability and reuse efficiency of platelet concentration are improved, and it is suitable for complex sample conditions.

The invention relates to a method for constructing a preeclampsia prediction model by using clinical laboratory data and a related application thereof. Specifically, the preeclampsia risk prediction model is constructed based on a plurality of clinical indexes of pregnant women, a plurality of clinical laboratory data and insulin growth binding factor binding protein 1 and / or placental growth factors. The clinical laboratory data comprises leukocyte count and / or urine protein, and further comprises any one or combination of platelet count, monocyte proportion, glutamic-straw / glutamic-pyruvic transaminase ratio, glutamyltranspeptidase, uric acid and high-density lipoprotein. The constructed preeclampsia risk prediction model can provide a reliable implementation means for early prevention and early treatment of preeclampsia. Meanwhile, the sensitivity of the prediction model is 88.0% when the specificity of early eclampsia is 85.04% and the sensitivity of the prediction model is 62.5% when the specificity of late eclampsia is 85.04% in a complete independent verification set, and the detection performance of the prediction model is higher than that of the current detection performance.

The utility model discloses a lightweight platelet function detection device. The lightweight platelet function detection device comprises a detection module and a sample processing module, the sample treatment module comprises a multifunctional liquid suction needle for sucking liquid, a driving device and a dilution module; the multifunctional liquid suction needle is connected with the dilution module through the liquid path pipe, and the driving device controls the multifunctional liquid suction needle to move. The detection module comprises one or more sample cup position devices for placing sample cups, and one or more built-in reagent positions are arranged in the sample cup position devices. All the sample cup positions and the built-in reagent positions are arranged in a movement track area of the multifunctional liquid suction needle. According to the design, the structure and the flow of the platelet function detector adopting the original continuous counting method are simplified, and electromagnetic valves required by the device are reduced by 30%, so that the cost of the device is reduced, and the failure rate is correspondingly reduced.

The invention discloses a clinical prediction model for the dyslipidemia probability of a child hepatolenticular degeneration patient and a design method, and belongs to the technical field of medical information. The clinical prediction model comprises an input module for receiving patient parameter indexes consisting of an age group (Age group, lt, 10 years old or more), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), homocysteine (Hcy), superoxide dismutase (SOD) and platelet count (PLT); the processing module is connected with the input module and calculates the prediction probability of the patient according to the model, and the output module is connected with the processing module and outputs the probability of dyslipidemia of the child hepatolenticular degeneration patient, which is finally obtained by the clinical prediction model. The prediction model established by the invention has good distinction degree, calibration degree and clinical practicability, has relatively high accuracy, and can be conveniently used for early recognition and risk prediction of dyslipidemia caused by hepatolenticular degeneration of children.

The invention relates to a cell image analyzer, a sample analysis system and a cell image analysis method. The cell image analyzer comprises: an imaging device for shooting a cell image; the bearing device is used for bearing the blood smear on which the blood film is applied; the control device is used for controlling the blood smear and the imaging device to move relative to each other, so that a plurality of shooting points in a target area of the blood film are respectively positioned in a visual field of the imaging device, and controlling the imaging device to shoot images of the shooting points in the visual field of the imaging device so as to obtain target cell images of the plurality of shooting points in the target area; the image analysis device is used for identifying platelets in the multiple target cell images and acquiring actual platelet distribution information of the blood membrane based on the platelets identified in the multiple target cell images and the shooting positions of the multiple target cell images in the smearing direction; and based on the actual platelet distribution information, acquiring platelet count and / or judging whether the to-be-detected blood sample is a platelet aggregation sample or not.

Provided herein are methods and related compositions and kits for dissolution of platelet clumps formed in collected blood samples. The present methods, compositions and kits are useful for improving blood sample quality and blood assay accuracy in a lab setting, especially in preventing misdiagnosis such as pseudothrombocytopenia or pseudoleukocytosis.

The invention discloses a blood storage device for medical examination, and belongs to the field of medicine.The blood storage device comprises a storage cabinet, a lower storage space and an upper storage space are arranged in the storage cabinet, an L-shaped spray head frame is installed at the top of the storage cabinet, cooling equipment is arranged on the side face of the storage cabinet, and the L-shaped spray head frame is connected with the cooling equipment through a pipeline; a pushing mechanism is arranged at the inner bottom of the lower storage space, a hanging rod frame is arranged at the top of the lower storage space, and sliding seats are symmetrically and slidably connected to the surface of the hanging rod frame. The cooling equipment is matched with the L-shaped spray head frame and the pipeline, cold air can be stably conveyed to the lower storage space and the upper storage space in the storage cabinet, a low-temperature environment suitable for platelet storage is created, and the platelet activity and solidification process is delayed through temperature control.

The utility model relates to the field of biomedical technology, concretely is a kind of platelet-rich plasma preparation device.The device includes storage tube, sealing cover and piston assembly.Storage tube is divided into storage part and injection part, and stop structure is arranged in storage cavity;Sealing cover is in interference fit with injection part and can be punctured, and closed blood sampling is realized in combination with vacuum negative pressure cavity.Piston assembly realizes locking and release by the cooperation of elastic movable head and stop structure, ensures that each blood layer is independently pushed after centrifugal stratification, and avoids cross contamination.Storage tube is made of transparent material and is provided with scale, so that stratification state and accurate separation can be observed.The device is integrated with blood sampling, centrifugation and extraction functions, and PRP preparation can be completed through single centrifugation and push-pull piston, which is convenient to operate and high in efficiency.The utility model solves the problems of complex operation, low separation efficiency and easy pollution of traditional method, and significantly improves the reliability and practicality of PRP preparation.

The invention discloses a blood extraction and centrifugation integrated device in the field of medical instruments, which comprises a tank body, the top of the tank body is communicated with an inlet, the inlet is communicated with a blood transfusion tube, the bottom of the tank body is rotatably connected with a centrifugation structure, the side wall of the bottom of the tank body is communicated with a first outlet and a second outlet, the first outlet is communicated with a blood return tube, and the second outlet is communicated with a separation tube. The inner side wall of the tank body is slidably connected with a partition plate in the vertical direction, the partition plate divides the tank body into a centrifugal chamber and a plasma storage chamber, the centrifugal chamber is communicated with the plasma storage chamber through a siphon, the input end of the siphon is communicated with a valve, a piston of the valve is connected with an elastic rope, and the other end of the elastic rope is fixedly connected with the top of the partition plate. According to the scheme, the functions of centrifugation, separation and blood return are integrated in one tank body, and the whole process is not contacted with air, so that sealed centrifugation, sealed separation and sealed blood return are realized, the blood can be prevented from being polluted, and the safety in an autologous platelet-rich plasma process is ensured.

This invention provides a means to obtain more clinically useful information when analyzing particles contained in blood samples using metachromatic positive dyes. In a particle analysis method for analyzing particles contained in blood samples, particles are stained with a metachromatic positive dye; the stained particles are irradiated with light; the intensity of a first fluorescence from the stacking component of the metachromatic positive dye and the intensity of a second fluorescence from the embedded component of the metachromatic positive dye are measured, the first and second fluorescence being emitted by each particle contained in the blood sample; the intensities of the first and second fluorescence emitted by each particle are normalized according to the size of each particle to obtain the fluorescence concentration of each of the first and second fluorescence in each particle; in a two-dimensional plot of the normalized fluorescence concentrations, each particle is clustered into multiple particle clusters, including at least two of erythrocyte clusters, platelet clusters, and nucleated cell clusters; and a histogram is created where the intensity of the first fluorescence is a histogram of the RNA amount of the class and the intensity of the second fluorescence is a histogram of the DNA amount of the class included in at least one of the multiple particle clusters.

The present application relates to the technical field of platelet aggregation detection, and specifically discloses a clinical platelet aggregation detection carrier, which comprises an instrument body and further comprises: a detection assembly arranged inside the instrument body, which is used for detecting different types of samples of lipemia, anemia and normal blood and selecting centrifugal operation of the blood samples; the detection assembly can detect different types of samples of lipemia, anemia and normal blood, and can automatically indicate whether centrifugal operation of the blood is needed according to the types of the detected samples; through the sampling assembly, the blood samples at different layer depths can be automatically adjusted according to the lipemia, anemia and normal blood samples detected by the detection assembly; through the agent adding assembly, the amount of the added inducing agent can be automatically adjusted according to the sample amount taken by the sampling assembly, so that the concentration of the mixed inducing agent reaches the specified range, thereby improving the detection accuracy of the platelet aggregation degree.

The present invention provides an automated and programable device equipped with a plurality of laser diodes. The device includes a housing which contains a closed chamber configured to receive and hold at least one container enclosure, such as a tube, a vial, a syringe, or a catheter, containing a sample including cells or body fluids. The device may include at least one control means configured to provide multiple settings for the plurality of laser diodes for activation of platelets, blood, plasma, and stem cells in a sample. The plurality of laser diodes may include four low level laser diodes (350, 650, 810 and 900 nm). The device may provide four pre-programmed settings for activation of platelets, blood, plasma, and stem cells in a sample. The device further has the capability to set up and save specific protocols for predetermined purposes, such as, for example without limitation, therapeutic and investigational purposes.

The invention discloses a platelet dynamic detection method, which can start a first detection mode and a second detection mode: when the first detection mode is started, a first to-be-detected sample is supplied to a detection channel according to a preset first statistical magnitude, and a first platelet detection result is output, so that the method has the advantage of high detection efficiency; and when the second detection mode is started, counting the number of platelet particles in the process of supplying a second to-be-detected sample to the detection channel, and outputting a second platelet detection result when the counted number of platelet particles is greater than or equal to a preset first preset platelet particle number threshold value. It can be guaranteed that the enough number of platelet particles can be counted, and the detection precision is improved. In conclusion, according to the platelet dynamic detection method, the first detection mode and the second detection mode can be started according to whether the sample is the low-value platelet sample or not, and the detection efficiency can be improved to the maximum extent while the detection precision is improved.

The invention discloses a single-sampling platelet acquisition auxiliary reminding system, which takes an intelligent chip as a core operation carrier and constructs a precise sensing link with a front-end intelligent sensor. The intelligent chip obtains a blood sampling pipeline pressure sequence and a blood sampling pump flow rate, utilizes a phase locking technology to deeply analyze a physical signal fed back by the intelligent sensor, recognizes a collection or feedback state of a machine, extracts a pressure gradient, a fluctuation index and a vein state score according to the collection or feedback state, introduces a risk self-adaptive dynamic weight fusion mechanism on the basis, and finally obtains the blood sampling pipeline pressure sequence and the blood sampling pump flow rate. The pressure interval is sensed in real time through the risk amplification factor, the weight of the pressure gradient feature is non-linearly amplified when the pressure is close to the danger threshold value, the technical defect that a traditional static weighting model is insufficient in danger edge early warning sensitivity is overcome, and therefore the accuracy of blood supply capacity evaluation is remarkably improved.

Provided herein are methods and related compositions and kits for dissolution of platelet clumps formed in collected blood samples. The present methods, compositions and kits are useful for improving blood sample quality and blood assay accuracy in a lab setting, especially in preventing misdiagnosis such as pseudothrombocytopenia or pseudoleukocytosis.

1. Name of the product in this design: Blood separation device. 2. Application of this design: This design is used for centrifugation of blood to prepare platelet-rich plasma. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

1. The name of the design product: blister packaging box. 2. The use of the design product: packaging box for storing tools for extracting platelet-rich plasma from blood samples. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

This invention relates to the interdisciplinary field of biomedical detection and Internet of Things (IoT) sensing technology, specifically disclosing a platelet-rich plasma concentration detection system based on IoT biosensors. The system includes a microfluidic sensor chip, a multi-frequency electrochemical impedance spectroscopy (MES) acquisition unit, a cell morphology identification module, an IoT communication unit, and a remote data processing server. It monitors platelet dynamic aggregation in real time through a three-electrode system, and combines high-dimensional features of broadband impedance spectroscopy with a pre-trained convolutional neural network model to accurately distinguish between simple platelet aggregates, platelet-leukocyte complexes, and microthrombus structures. Furthermore, it leverages the IoT architecture to complete encrypted data upload, remote model optimization, and intelligent coagulation risk assessment. Through the above technical solutions, this invention improves the sensitivity, specificity, and clinical applicability of the detection, constructing a closed-loop blood monitoring system from bedside detection to cloud-based decision support.

The embodiments of the present application relate to a platelet counting method and a blood cell analyzer. The method comprises: aspirating a blood sample to be tested; mixing one portion of said blood sample with a diluent to prepare a first test sample, and mixing the other portion of said blood sample with a hemolytic agent and fluorescent dye to prepare a second test sample; performing impedance measurement on the first test sample, in order to obtain an electrical signal of the first test sample; performing optical measurement on the second test sample, in order to obtain at least one optical signal from among a scattered light signal and a fluorescent light signal of the second test sample; at least on the basis of the electrical signal of the first test sample, obtaining platelet distribution information of said blood sample; and at least on the basis of the pulse width of an optical signal among the at least one optical signal that corresponds to platelets in the second test sample, and the platelet distribution information, obtaining a platelet count value. Thus, an accurate platelet count can be obtained at a low cost.

Provided are apparatuses and methods that include imaging a blood sample that is a suspension of cells deposited in a sample chamber. The cells are allowed to settle in the sample chamber to form a monolayer of cells. At least one microscopic image of the monolayer of cells is acquired using a microscope (24) while the microscope is focused at a monolayer depth level, and a first platelet count of platelets that have settled within the monolayer is determined. Additional microscopic images of the sample are acquired while the microscope is focused at depth levels different from the monolayer depth level, and a second platelet count of platelets that are not settled within the monolayer is determined. An output is generated based on the first platelet count and the second platelet count. Other applications are also described.

The utility model relates to the technical field of platelet aggregation function detection, and discloses a platelet aggregation function detection reagent card which comprises a shell. The shell is provided with a sample bin, a separation area, a poor platelet containing cavity and a rich platelet containing cavity, the sample bin is provided with an opening facing the outside, an inlet of the separation area is communicated with the sample bin through a liquid inlet channel, and the separation area comprises a first separation channel communicated with the poor platelet containing cavity and a second separation channel communicated with the rich platelet containing cavity. The first separation channel and the second separation channel are filled with first filler and second filler respectively, and the aperture formed by the second filler is larger than that of the first filler. The operation process is simplified, and the separation efficiency is improved, so that the subsequent detection efficiency is improved.