173 results about "PLT - Platelets" patented technology

The invention relates to the technical field of blood separation, in particular to a platelet concentration-based gravity separation system, which comprises a tension disturbance extraction module, a viscosity response positioning module, a sedimentation retarding judgment module, a platelet export judgment module and a concentration layer interface output module. According to the method, real-time extraction of tension change frequency and mutation amplitude is introduced, and a normalization processing mode of disturbance polymerization indexes is combined, so that a mechanical unstable area under tiny disturbance in the blood standing sedimentation process is effectively described, and the sensitive recognition capability on potential layered behavior changes is enhanced. Through continuous tracking of a viscosity behavior curve in a disturbance time period, an accurate time anchor point is provided for judgment of a subsequent liquid column motion state. On the basis of microscopic changes of the liquid column height and the rate, through combined judgment of the acceleration change trend and the attenuation amplitude, the settlement state is distinguished no longer depending on a macroscopic parameter threshold value, but is dynamically regulated and controlled through the change trend and a fluctuation sequence.

The invention discloses a diabetic nephropathy risk assessment and prediction system based on platelet indexes, and particularly relates to the technical field of disease risk prediction, which comprises a platelet index acquisition module, a drug use data acquisition module, a drug intervention assessment module, an index correction module, a clustering analysis module and a diabetic nephropathy risk assessment module, the method comprises the following steps: acquiring platelet related detection indexes and historical medication data of a patient, calculating a drug intervention influence index and generating a correction factor, realizing platelet index reverse reduction correction by adopting a convolutional neural network model, determining a similar group in combination with clustering analysis, and dynamically evaluating the risk of diabetic nephropathy based on the average morbidity of the group. Personalized accurate prediction is realized; the platelet index correction accuracy is improved, individualized drug intervention elimination is achieved, the similar population clustering analysis precision is enhanced, diabetic nephropathy risk prediction is dynamically adjusted in combination with comprehensive scores, and the early screening and individualized intervention effects are improved.

The invention relates to the technical field of medical artificial intelligence, in particular to a vascular embolism risk prediction method based on big data analysis, and the method comprises the steps: collecting a pulse pressure fluctuation rate, a microcirculation resistance index and a platelet adhesion gradient through a multi-source sensor, and extracting dynamic physiological parameter time sequence features; constructing a hemodynamic finite element model based on CTA and VFI image data, and obtaining a vascular mechanical feature vector; deep coupling of the pulse pressure spectrum and the circumferential stress is achieved through dynamic time warping and convolution mapping, and a multi-modal risk feature set is generated; and performing cross-modal coding by using the double-branch graph neural network, and outputting an acute embolism probability and a three-dimensional risk thermodynamic diagram. According to the method, physiological, image and mechanical multi-dimensional information is fused, and the method has the advantages of being high in real-time performance, accurate in positioning and good in interpretability and is suitable for risk prediction and auxiliary diagnosis of clinical cardiovascular and cerebrovascular events.

The invention discloses a clinical prediction model for the probability of occurrence of spleen hyperfunction of a hepatolenticular degeneration patient and a design method, and belongs to the technical field of medical information. The clinical prediction model comprises an input module for receiving patient parameter indexes consisting of an aspartate aminotransferase and platelet ratio index (APRI), a hepatic fibrosis 4 index (FIB-4), a liver hardness value (LSM) and a portal vein diameter (PVD); the processing module is connected with the input module and calculates the prediction probability of the patient according to the model; and the output module is connected with the processing module and outputs the risk probability of occurrence of the hypersplenic function of the hepatolenticular degeneration patient obtained by the clinical prediction model. The clinical prediction model established by the invention has good distinction degree, calibration degree and clinical practicability, has relatively high accuracy, and can be conveniently used for early recognition and risk prediction of hypersplenic function of hepatolenticular degeneration patients.

The present invention relates to methods for determining a blood gas parameter and / or a basic metabolic panel parameter in a blood sample comprising combining the blood sample with an anti-coagulant and an anti-platelet agent, and determining said blood gas parameter and / or parameter in the sample. In some aspects, the invention relates to determining said parameters in samples that have been subjected to pre-analytical stress.

To provide a specimen measurement device and a specimen measurement method that readily confirms the suitability of a sample as platelet-rich plasma.SOLUTION: A specimen measurement device 1 comprises a test section 13 for measuring optical information of platelet-rich plasma and platelet-poor plasma prepared from a blood specimen, a control sections 210 and 213 for acquiring information regarding platelet aggregation of the blood specimen based on the optical information of the platelet-rich plasma and platelet-poor plasma, and a display 4 for displaying information regarding platelet aggregation. The control sections 210 and 213 acquire evaluation information regarding the suitability of the platelet-rich plasma as a sample based on the measurement results of the platelet-rich plasma by the test section 13, and make the display 4 display the information.SELECTED DRAWING: Figure 15

In the agglutinated platelet parameter detection method and the identification AI training method thereof, a blood sample is preprocessed, and a microscopic examination sample is obtained and tiled; standing the platelets to sink to the bottom; shooting to obtain a microscopic examination sample image; according to the method, normal platelets and agglutinated platelets are identified and labeled, a labeled picture is obtained for AI training, an obtained AI feature data set A comprises normal platelet features, and an AI feature data set A comprises agglutinated platelet features. Identifying a microscopic examination sample image by using an AI identification algorithm, identifying agglutinated platelets in the blood sample in a selected area S1 of the image, and obtaining the total number NUMS1 of the agglutinated platelets in the blood sample in the selected image; and the AI recognition algorithm recognizes the agglutinated platelets in the blood sample according to the agglutinated platelet feature data set. The recognition of the agglutinated platelets is completed by utilizing advanced AI computing power, so that the analysis of the agglutinated platelets is more efficient and more accurate, and the dimension of platelet function analysis based on images is expanded.

Provided is a method for assisting in grasping the status of platelet activation, by developing a biomarker that more accurately reflects platelet activation in vivo, said method being usable in testing for thrombotic hemostatic diseases. The method for assisting in grasping the status of platelet activation comprises (1) measuring the concentration of soluble CLEC-2 and a platelet count in a sample obtained from a subject, and (2) calculating a value of [soluble CLEC-2 concentration] / [platelet count] by dividing the soluble CLEC-2 concentration by the platelet count. If desired, the method may further comprise (3) comparing the value with a value of [soluble CLEC-2 concentration] / [platelet count] obtained by using samples from healthy persons.

The invention discloses a hematology analyzer and a platelet numerical value measuring method, in the hematology analyzer, an analysis unit is used for receiving a pulse signal to generate a first image, receiving an optical signal to generate a second image, obtaining a platelet original numerical value based on the first image, obtaining an interference coefficient of a leukocyte fragment based on the second image, and obtaining the platelet numerical value based on the interference coefficient; and obtaining a platelet measurement value based on the platelet original value and the interference coefficient. Through the cooperation of the impedance module and the flow fluorescence module, the platelet original value in the blood cell sample and the interference coefficient of the leukocyte fragment are detected, and the accuracy of each step in the calculation process of the platelet measurement value is ensured. Meanwhile, the platelet measurement numerical value is calculated through the analysis unit based on the platelet original numerical value and the interference coefficient, so that the accuracy of the blood cell analyzer for measuring the platelet measurement numerical value is improved, the practicability of the blood cell analyzer is improved, and the use experience of a user on the blood cell analyzer is improved.

A sample measuring apparatus according to an embodiment may be a sample measuring apparatus for measuring a platelet aggregation function of a blood sample. The apparatus may include: a detection section configured to measure optical information of platelet rich plasma and platelet poor plasma prepared from a blood sample; a control section configured to acquire information on a platelet aggregation function of the blood sample based on optical information of platelet rich plasma and platelet poor plasma; and a display configured to display information on a platelet aggregation function. The controller is configured to obtain evaluation information on suitability of the platelet-rich plasma as a sample based on a measurement result of the platelet-rich plasma by the detection portion, and display the evaluation information on the display.

The utility model provides a blood sampling and centrifuging integrated platelet-rich plasma preparation device which comprises a centrifugal sleeve and a blood sampling assembly coaxially and detachably installed in the centrifugal sleeve, and the blood sampling assembly comprises a blood collecting tube and a vein puncture needle connected to the head end of the blood collecting tube; the outer wall of the blood collecting tube is provided with a needle head containing bin used for containing a needle head of the vein puncture needle. According to the blood collection and centrifugation integrated platelet-rich plasma preparation device, a container does not need to be replaced in the blood collection and centrifugation process, and contact between the blood and the outside is reduced; and the needle head of the vein puncture needle can be properly stored, so that bacterial contamination is really avoided. Moreover, the needle head is accommodated in the needle head accommodating bin, so that the requirement on the length of the centrifugal sleeve can be reduced, and the blood carrying amount of the centrifugal sleeve with the same size is more.

The present invention relates to the technical field of platelet function analysis equipment, and specifically relates to a platelet function analysis equipment, mainly including a machine body. A support plate is fixedly installed on the top surface of the machine body, and a fixing plate is fixedly installed on the top surface of the support plate. A cover body is rotatably connected to the top surface of the fixing plate. A reagent tube is arranged below the cover body. An adjusting mechanism is arranged above the support plate. A fixing mechanism is arranged inside the fixing plate. A pressing mechanism is arranged above the fixing box. By pushing the moving plate with a buckle, the moving plate squeezes the airbag. The airbag contracts under the extrusion, and the gas inside is transported to the fixing box through the connecting pipe, pushing the piston plate to move. When the piston plate moves, it drives the support rod and the clamping plate to move, and the clamping plate clamps and fixes the reagent tube. When vibration or external force acts during the detection process, the reagent tube is not likely to shake or loosen, improving the stability of the reagent tube and the accuracy of the detection result, and thus ensuring the reliability of the overall analysis.

The invention relates to the technical field of biology, and discloses a method for detecting thrombin production promotion capability of extracellular vesicles in a blood sample, which comprises the following steps: centrifuging the blood sample collected within 2 hours at 2500g at room temperature for 15 minutes, sucking upper platelet-deficient plasma and placing in a centrifuge tube, centrifuging at 2500g at room temperature again for 15 minutes, and sucking upper platelet-free plasma; centrifuging the obtained platelet-free plasma at 4 DEG C at 20000g for 1 hour; and sucking the upper-layer extracellular vesicle-free plasma for later use, taking the obtained extracellular vesicle precipitate as a to-be-detected sample, and detecting the thrombin generation promotion capability of the extracellular vesicles by using a thrombin generation analyzer. The method provided by the invention can be used for accurately detecting the capability of the extracellular vesicles in the blood sample for promoting thrombin generation, has the advantages of convenience in operation, easiness in obtaining the sample, noninvasiveness, no damage, high detection speed, low cost and the like, has important significance on thrombus risk assessment and prediction, and has better clinical application value.

The invention provides a micro-fluidic chip for detecting platelet aggregation function, and relates to the technical field of platelet aggregation function detection.The micro-fluidic chip comprises a chip body, the chip body is provided with at least one group of detection parts, and each group of detection parts comprises a sample adding groove and at least one group of detection units; the detection unit comprises a coating runner and a reaction cavity; the inner wall of the coating flow channel is coated with an activating agent coating, and the length extending direction of the coating flow channel is inclined relative to the radial direction with the rotation center as the circle center, so that the proximal end and the distal end of the coating flow channel are located on different radial lines with the rotation center as the circle center respectively. Through the arrangement, local retention or dead zones are avoided, the detection efficiency is improved, the dissolution rate of the activator is effectively improved, the dissolution rate of an activator coating is more than 5 mu g / s, the activator is ensured to be fully dissolved, the error absolute value of the final concentration of the activator in a sample is less than 6%, the detection error is reduced, and the detection accuracy is improved.

A system includes: a dialysis machine configured to provide a dialysis treatment for a patient; at least one fluid line; a sensor disposed on the at least one fluid line, wherein the sensor is configured to obtain platelet measurements from fluid passing through the at least one fluid line; and a processing system configured to: receive the platelet measurements from the sensor; determine whether the platelet measurements are indicative of a risk of Heparin-induced thrombocytopenia (HIT) to the patient; and in response to determining that the platelet measurements are indicative of a risk of HIT to the patient, provide an alert to the patient and / or a clinician based on the platelet measurements.

The invention relates to the technical field of biology, in particular to a freeze-dried platelet quality control product and a preparation method and application thereof.The method comprises the following steps that qualified platelets are screened according to parameter requirements of the quality control product and serve as raw materials to prepare the freeze-dried platelets; adding a protective agent into the platelet suspension, incubating at 37 DEG C for 1-4 hours, and standing for 30 minutes to obtain a platelet incubation solution; sub-packaging the platelet incubation liquid into freeze-drying bottles, pre-freezing at-80 DEG C for 4 hours, then carrying out primary drying and secondary drying in a freeze dryer, and sealing to obtain a platelet freeze-dried product; carrying out sampling detection on each batch of freeze-dried platelet products, marking and labeling each batch of products according to actual detection values after the freeze-dried platelet products are qualified so as to complete production of finished products, and storing the finished products at the temperature of 20-25 DEG C. The blank of platelet aggregation instrument quality control products is filled, an innovative solution is provided for instrument calibration, performance verification and batch-to-batch detection, and the reliability and consistency of platelet function detection are remarkably improved.

The utility model discloses a platelet aggregation function detection disc, which comprises a disc body and at least one microfluidic structure arranged on the disc body, the microfluidic structure comprises a sample adding groove, a separation groove, a precipitation groove and a detection groove which are sequentially arranged from the rotating center of the disc body to the periphery, a sample adding hole for liquid to enter is formed in the sample adding groove, the separation groove is connected with the sample adding groove and is connected with the detection groove through a first micro-channel, and the precipitation groove is connected with the separation groove. By adopting the disc, the separation of whole blood and the detection of the platelet aggregation function can be realized.

The present invention provides a pharmaceutical composition for use in a method of treating pulmonary arterial hypertension (PAH). [Solution] A pharmaceutical composition for use in a method for treating pulmonary arterial hypertension (PAH) in a patient in need, comprising an ActRIIA fusion protein, wherein the ActRIIA fusion protein is (i) ActRIIA polypeptide containing a specific amino acid sequence, (ii) Fc domains containing an amino acid sequence that is at least 95% identical to a specific amino acid sequence, (iii) comprising a linker domain located between the ActRIIA polypeptide and the Fc domain, Herein, the ActRIIA fusion protein is administered in a first dose of 0.3 mg / kg and a second dose of 0.7 mg / kg, wherein the second dose is administered after confirming that the patient has an acceptable hemoglobin level and / or platelet count, in a pharmaceutical composition.

The application discloses a platelet performance index evaluation method and device. The method comprises the following steps: collecting platelets to be detected; collecting cloud and mist characteristic data of the platelets to be detected by using an image and video device, wherein the cloud and mist characteristic data comprises cloud and mist characteristic image data and / or cloud and mist characteristic video data; and evaluating platelet performance indexes by using the cloud and mist characteristic data of the platelets to be detected. The application can accurately, quickly and at low cost detect platelet performance indexes, and solves problems of long time consumption, high cost and large result error of a traditional platelet performance detection method.

The utility model relates to the technical field of medical instruments, in particular to a platelet-rich plasma raw material extractor which comprises a blood sampling outer barrel, a blood sampling movable barrel inserted into an inner cavity of the blood sampling outer barrel in a sliding mode in the axial direction, an injection inner barrel detachably connected to an inner cavity of the blood sampling movable barrel and an injection push rod inserted into an inner cavity of the injection inner barrel in a sliding mode in the axial direction. The head of the blood sampling outer cylinder is detachably connected with a sealing cover for blocking a needle hole of the blood sampling outer cylinder, the head of the blood sampling movable cylinder is provided with a blood sampling piston which is in sealed sliding connection with the inner circumferential wall of the blood sampling outer cylinder, and the head of the injection push rod is provided with an injection piston which is in sealed sliding connection with the inner circumferential wall of the injection inner cylinder; a through hole is formed in the head of the blood sampling movable cylinder, the needle hole of the blood sampling outer cylinder, the through hole and the needle hole of the injection inner cylinder jointly form a fluid communication channel, and a fixing piece used for limiting relative sliding of the injection push rod and the injection inner cylinder is detachably connected between the injection push rod and the injection inner cylinder. The method has the effect of accurately controlling the extraction amount of the platelet-rich plasma.

The utility model relates to the technical field of medical instruments, and discloses a conservator for subpackaging platelet-rich plasma, which comprises a preservation box, and the top of the preservation box is provided with an inner adjusting sealed placing device. The inner adjusting sealing placement device comprises a top end placement frame, an elastic connecting pad, a sealing seat, a placement plate, a test tube protection barrel, an inner placement barrel piece, a connecting column piece, a magnetic attraction piece, a sealing insertion barrel and a magnet patch. According to the conservator for subpackaging the platelet-rich plasma, an inner adjusting sealing placement device is arranged, a test tube protection barrel is far longer than a conventional test tube, the test tube can be used when the test tube is too long, the test tube can be pushed until the top end of the test tube is flush with an inner placement barrel part during use, and sealing is convenient through cooperation of a sealing insertion barrel and a magnet patch; and when the test tubes are placed, the arranged clamping and placing assembly can be matched with the test tubes of various lengths to conduct sealing and clamping treatment, the test tubes can make contact with the sealing insertion barrel which is a sealing piece when the test tubes are too high or too low, and the adaptation degree is high.

The present application relates to the technical field of platelet concentration, in particular to a platelet concentration method and system based on gravity sedimentation, comprising the following steps: obtaining sedimentation path unit parameters and collecting speed difference values, screening staggered difference point and judging acceleration trend, extracting decreasing curvature difference to determine boundary, adjusting inclination angle to collect speed change rate and screen falling path, calculating vector to establish extraction path to obtain secondary concentration data. In the present application, by extracting sedimentation speed difference value and acceleration change trend, the layered boundary area is identified, the positioning accuracy of the concentration limit is improved, based on the inclination disturbance induced dynamic response, the path unit with outstanding speed rising rate is screened, the perception ability and layered clarity of the limit area are enhanced, with the help of speed vector direction and center position calculation, a stable linear extraction path is constructed, efficient recovery and focused extraction of trace platelets are realized, the precision, stability and reuse efficiency of platelet concentration are improved, and it is suitable for complex sample conditions.

The invention relates to a method for constructing a preeclampsia prediction model by using clinical laboratory data and a related application thereof. Specifically, the preeclampsia risk prediction model is constructed based on a plurality of clinical indexes of pregnant women, a plurality of clinical laboratory data and insulin growth binding factor binding protein 1 and / or placental growth factors. The clinical laboratory data comprises leukocyte count and / or urine protein, and further comprises any one or combination of platelet count, monocyte proportion, glutamic-straw / glutamic-pyruvic transaminase ratio, glutamyltranspeptidase, uric acid and high-density lipoprotein. The constructed preeclampsia risk prediction model can provide a reliable implementation means for early prevention and early treatment of preeclampsia. Meanwhile, the sensitivity of the prediction model is 88.0% when the specificity of early eclampsia is 85.04% and the sensitivity of the prediction model is 62.5% when the specificity of late eclampsia is 85.04% in a complete independent verification set, and the detection performance of the prediction model is higher than that of the current detection performance.

The utility model discloses a lightweight platelet function detection device. The lightweight platelet function detection device comprises a detection module and a sample processing module, the sample treatment module comprises a multifunctional liquid suction needle for sucking liquid, a driving device and a dilution module; the multifunctional liquid suction needle is connected with the dilution module through the liquid path pipe, and the driving device controls the multifunctional liquid suction needle to move. The detection module comprises one or more sample cup position devices for placing sample cups, and one or more built-in reagent positions are arranged in the sample cup position devices. All the sample cup positions and the built-in reagent positions are arranged in a movement track area of the multifunctional liquid suction needle. According to the design, the structure and the flow of the platelet function detector adopting the original continuous counting method are simplified, and electromagnetic valves required by the device are reduced by 30%, so that the cost of the device is reduced, and the failure rate is correspondingly reduced.

The present invention relates to a method for determining a mortality risk and / or probability of a healthy lifespan of a dog; said method comprising determining the level of one or more biomarker(s) in one or more samples obtained from the dog, wherein the one or more biomarker(s) is selected from white blood cell count, serum albumin, serum alkaline phosphatase, serum creatine kinase, haemoglobin, haematocrit, mean corpuscular haemoglobin, serum glucose, mean red cell volume, serum globulin, serum calcium, platelet count, and / or red blood cell count.

The invention discloses a clinical prediction model for the dyslipidemia probability of a child hepatolenticular degeneration patient and a design method, and belongs to the technical field of medical information. The clinical prediction model comprises an input module for receiving patient parameter indexes consisting of an age group (Age group, lt, 10 years old or more), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), homocysteine (Hcy), superoxide dismutase (SOD) and platelet count (PLT); the processing module is connected with the input module and calculates the prediction probability of the patient according to the model, and the output module is connected with the processing module and outputs the probability of dyslipidemia of the child hepatolenticular degeneration patient, which is finally obtained by the clinical prediction model. The prediction model established by the invention has good distinction degree, calibration degree and clinical practicability, has relatively high accuracy, and can be conveniently used for early recognition and risk prediction of dyslipidemia caused by hepatolenticular degeneration of children.

The present invention provides a rapid detection microfluidic chip and detection method for prostate cancer markers, which belongs to the technical field of rapid screening of prostate cancer. The technical problems of the existing detection methods being cumbersome to operate and having a long detection cycle are solved. The technical solution is as follows: it includes a microarray structure for blood separation and a color development microchannel structure for detecting free prostate-specific antigen F-PSA and total prostate-specific antigen T-PSA respectively; the microarray composed of "V"-shaped grooves forms a blood separation structure, which separates red blood cells, white blood cells, and large platelet particles in the blood by physical separation; the functional fragments of F-PSA and T-PSA are fixed and captured in advance in the color development microchannel structure, and the semi-quantitative detection of F-PSA and T-PSA is achieved by measuring the color development length of the color development microchannel. The beneficial effects of the present invention are: the microfluidic chip of the present invention is simple to operate, the results are easy to read, and the analysis is fast.

To provide a method of determining the concentration of one or more substances in a fluid and / or the platelet mass index of the fluid.SOLUTION: An optical detection assembly for monitoring a fluid includes a light source, a light detector array, and a controller. The controller receives signals from the light detector array that are indicative of intensity of light received by the light detector array after the light has passed through the fluid. The controller generates a scattering profile based on the signals, with the scattering profile including rising and falling edges each having a slope. The controller calculates one or both slopes and determines a platelet mass index (for a platelet-containing fluid) and / or a concentration of a substance in the fluid based on said slopes. The optical detection assembly may also be used to analyze a reference fluid having a known concentration of the substance, with signals received by the controller when analyzing the reference fluid being a factor when determining the concentration of the substance in the fluid of interest.SELECTED DRAWING: None

The invention relates to a cell image analyzer, a sample analysis system and a cell image analysis method. The cell image analyzer comprises: an imaging device for shooting a cell image; the bearing device is used for bearing the blood smear on which the blood film is applied; the control device is used for controlling the blood smear and the imaging device to move relative to each other, so that a plurality of shooting points in a target area of the blood film are respectively positioned in a visual field of the imaging device, and controlling the imaging device to shoot images of the shooting points in the visual field of the imaging device so as to obtain target cell images of the plurality of shooting points in the target area; the image analysis device is used for identifying platelets in the multiple target cell images and acquiring actual platelet distribution information of the blood membrane based on the platelets identified in the multiple target cell images and the shooting positions of the multiple target cell images in the smearing direction; and based on the actual platelet distribution information, acquiring platelet count and / or judging whether the to-be-detected blood sample is a platelet aggregation sample or not.