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Stimulation of a nerve supplying the spleen

A nerve and spleen technology, applied in the field of neuromodulation, can solve problems such as off-target effects

Pending Publication Date: 2020-10-16
GALVANI BIOELECTRONICS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the electrical parameters used to elicit stimulation of neural activity in these references may lead to off-target effects such as changes in splenic artery and venous blood flow and changes in systemic arterial blood pressure and heart rate

Method used

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  • Stimulation of a nerve supplying the spleen
  • Stimulation of a nerve supplying the spleen
  • Stimulation of a nerve supplying the spleen

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Embodiment Construction

[0028] nerves surrounding the spleen

[0029] Innervation of the spleen is predominantly sympathetic or noradrenergic, with peptide neurons likely representing the majority of the remaining neurons. The human spleen is traditionally thought to be innervated only by the splenic plexus surrounding the splenic artery. The splenic artery is covered by nervous tissue that originates from the celiac plexus and continues to the spleen as the splenic plexus and splenic artery. The splenic plexus enters the spleen at the hilus, where the splenic artery bifurcates at terminal branches, and the splenic plexus continues with these branches into the parenchyma of the spleen.

[0030] The splenic plexus includes several fascicles that bypass the main splenic artery from the celiac artery to the spleen, each fascicle containing a small bundle of nerve fibers. The nerve cluster that bypasses the splenic nerve (or known as the periarterial nerve cluster) is referred to herein as the splenic a...

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Abstract

Stimulation of neural activity in a nerve supplying the spleen, wherein the nerve is associated with a neurovascular bundle, can modulate pro- and anti-inflammatory molecules levels, thereby reducinginflammation and providing ways of treating inflammatory disorders. The invention provides improved ways of treating inflammatory disorders which minimize off-target effects.

Description

technical field [0001] The present invention relates to neuromodulation of the nerves supplying the spleen, more specifically to devices, systems and methods for stimulating neural activity in the nerves, and even more specifically to signal parameters and electrode design. The present invention also relates to devices, systems and methods for stimulating neural activity in nerves for the treatment of inflammatory disorders. Background technique [0002] Inflammation plays a fundamental role in host defense and the progression of immune-mediated diseases (reviewed in [1]). The inflammatory response is initiated in response to injury and / or infection by chemical mediators (such as cytokines and prostaglandins) and inflammatory cells (such as leukocytes). A controlled inflammatory response is beneficial, for example, in eliminating harmful pathogens and initiating repair of damaged tissues to provide protection against infection. However, the inflammatory response can become...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N1/36A61B5/026A61N1/05A61B5/00
CPCA61B5/026A61N1/0556A61N1/36053A61N1/36121A61N1/36139A61N1/36178A61B5/01A61B5/021A61B5/024A61B5/027A61B5/053A61B5/0816A61B5/0836A61B5/087A61B5/14532A61B5/14539A61B5/14542A61B5/416A61B5/318
Inventor M·多内加D·J·周I·古普塔
Owner GALVANI BIOELECTRONICS LTD
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