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Oral pharmaceutical composition

A composition and drug technology, applied in the direction of drug combination, drug delivery, active ingredients of heterocyclic compounds, etc., can solve problems such as the stability reduction of cyanocobalamin

Inactive Publication Date: 2020-10-23
来必制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is a problem in this existing pharmaceutical composition that causes the decomposition of cyanocobalamin in the active ingredient, resulting in a greatly reduced stability

Method used

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  • Oral pharmaceutical composition
  • Oral pharmaceutical composition
  • Oral pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 9

[0063] According to the ingredients and contents shown in Table 1 to Table 3 below, the granules were made into granules through a dry granulation process, and then compressed into single-layer tablets by a tablet machine, so that the pharmaceutical compositions of Examples 1 to 9 were made into tablets. The components of the first active ingredient used in each of Examples 1 to 9 are also organized in Table 4.

[0064] [Table 1]

[0065]

[0066] [Table 2]

[0067]

[0068] [table 3]

[0069]

[0070] [Table 4]: Components of the first active ingredient

[0071]

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PUM

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Abstract

The present invention relates to an oral pharmaceutical composition capable of effectively suppressing decomposition of cyanocobalamin, thereby improving stability. The present invention relates to anoral pharmaceutical composition comprising: a first active ingredient comprising adenine or a pharmaceutically acceptable salt thereof, carnitine or a pharmaceutically acceptable salt thereof, a liver extract, a vitamin, and dimethyl biphenyl dicarboxylate; a second active ingredient comprising cyanocobalamin; an alkalizing agent comprising an alkaline organic salt compound or an alkaline inorganic salt compound; and a pharmaceutically acceptable excipient, exhibiting a pH of 5.5 to 9.0 in the state of 7.5% (W / V) aqueous liquid.

Description

technical field [0001] The invention relates to an oral pharmaceutical composition, which can effectively inhibit the decomposition of cyanocobalamin, thereby improving the stability. Background technique [0002] Adenine is one of the purine bases that make up nucleic acids, and is used as a precursor of ATP or ADP, which is used as an energy source in the body, and is also used to form cAMP that participates in cell signaling that occurs in the body. In addition, adenine acts as a neurotransmitter inhibitor in the brain, which can participate in guiding sleep and inhibiting wakefulness (Journal of Alzheimer's Disease 20(2010) S3-S15 S3 DOI10.3233 / JAD-2010-1379), while in the liver Participate in vasoconstriction, increase the breakdown of glycogen into glucose and inhibit fatty liver (Nature 204, 1196-1197 (19December 1964); DOI 10.1038 / 2041196a0). [0003] On the other hand, carnitine is a coenzyme necessary for fatty acid metabolism and has an amino acid derivative stru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/407A61K9/20A61K47/02A61K47/12A61P1/16A61K31/205A61K31/216A61K31/4415A61K31/52A61K31/525A61K31/714
CPCA61K9/2009A61K9/2013A61K31/205A61K31/216A61K31/4415A61K31/52A61K31/525A61K31/714A61K35/407A61P1/16A61K2300/00A61K9/0053A61K31/14A61K31/225A61K31/513
Inventor 朴孝珍朴叙薰朴相根
Owner 来必制药有限公司
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