Application of ATP binding cassette transmembrane transporter subfamily C member 3 in preparation of medicines for preventing and treating enterovirus 71 infection

Abstract

The invention relates to the technical field of biomedicine and particularly relates to a novel target point for resisting enterovirus 71 infection and application. According to the novel target pointand the application, a human colon cancer cell (Caco-2) serves as a target cell, the expression of related membranin transported by the target cell is declined by employing an RNA interference technology so as to look for a host factor capable of effectively inhibiting EV71-infected human colon cancer cells, and thus, the aim of blocking the EV71 infection from a source (intestinal canal) is achieved. According to the novel target point and the application, it is discovered that an ATP binding cassette transmembrane transporter subfamily C member 3 (ABCC3) plays a major role in EV71-infectedcells Caco-2, and the EV71 infection can be obviously inhibited by lowering the expression of the ABCC3. The invention provides application of the ABCC3 in preparation of medicines for preventing andtreating the enterovirus 71 infection, and a novel target point and treatment scheme is provided for clinically preventing and treating diseases such as hand-foot-mouth disease, meningitis, brain stemencephalitis and poliomyelitis caused by the EV71 infection.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a new target and application of anti-enterovirus 71 infection. Background technique [0002] Enterovirus 71 (EV71) belongs to the Picornaviridae Enterovirus genus Human Enterovirus A, and is one of the main pathogens that cause Hand-foot-mouth disease (HFMD). Currently, hand, foot and mouth disease is breaking out and spreading in many parts of the world, especially in the Asia-Pacific region. In my country, since the outbreak of hand, foot and mouth disease in several major provinces and cities in 2008, the number of people infected and the death rate of the disease have remained high, with more than 1 million cases and nearly 1,000 deaths reported every year. The main patients with HFMD are infants and young children under 5 years old. The clinical manifestations are fever, herpes and other symptoms on the hands, feet, buttocks and oral mucosa; a small number of children c...

AI Technical Summary

Problems solved by technology

[0007] However, there is no report on the role of ABCC3 and SLC7A7 molecules in virus-infected host cells. In-depth research on these two molecules will not only improve the understanding of EV71 infection and pathogenic mechanisms, but also contribute to the prevention and treatment of EV71 infection. Provide new ideas and targets

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