The invention relates to a double-vanilla preparation, which is a medicament prepared by the following raw materials in part by weight: 50-600 parts of white honeysuckle flower, 50-600 parts of weeping forsythia, 50-600 parts of wrinkled gianthyssop herb, 50-300 parts of peppermint, 50-600 parts of lithospermum, 50-300 parts of wormwood leaf and 50-300 parts of raw licorice. The invention also provides a preparation method of the double-vanilla preparation, which comprises the following steps: boiling and distilling the white honeysuckle flower, weeping forsythia and the like in water for 1-20 times and for 0.5-5 hours and simultaneously collecting essential oil for standby, wherein water is added for soaking for 0-2 hours before boiling and distilling, the quantity of water is 5-20 times of the weight of the seven kinds of traditional Chinese medicines; filtering the boiled liquid until the relative concentration of the filtrate is 0.5-2; adding ethanol in the filtrate, standing and filtering; recovering ethanol until the filtrate is tasteless; adjusting a pH (Potential of Hydrogen) value: adjusting the pH value of the filtrate obtained by recovering the ethanol to 3-7; and diluting, filtering and disinfecting. The invention has good pesticide effect to upper respiratory tract infection, remarkable treatment effects, quicker fever abatement of patients with a hand-foot-mouth disease and deflorescence and good medicine properties; and as the atomization preparation is adopted, the medicine can be conveniently used, and compliance of patients is good.