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Use of andrographolide and its derivatives in preparation of drugs for preventing and treating hand-foot-and-mouth disease

A technology for andrographolide, hand, foot and mouth disease, which is applied in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as insufficient evidence of effectiveness.

Inactive Publication Date: 2014-09-17
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are sporadic clinical reports of using andrographolide sulfonate Xiyanping to treat hand, foot and mouth disease, but the evidence of effectiveness is still insufficient, and there is no report on the study of model animals.

Method used

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  • Use of andrographolide and its derivatives in preparation of drugs for preventing and treating hand-foot-and-mouth disease
  • Use of andrographolide and its derivatives in preparation of drugs for preventing and treating hand-foot-and-mouth disease
  • Use of andrographolide and its derivatives in preparation of drugs for preventing and treating hand-foot-and-mouth disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Xiyanping can prevent death of suckling mice caused by EV71 hand, foot and mouth disease virus BJ09 / 07 strain infection

[0027] Experimental Materials:

[0028] 1) Main experimental equipment: Class II biological safety cabinet (Experimental Animal Center of Academy of Military Medical Sciences), mouse cage (Experimental Animal Center of Academy of Military Medical Sciences), sterile insulin syringe (purchased from BD Company of the United States), etc.

[0029] 2) Main experimental reagents: Xiyanping (purchased from Jiangxi Qingfeng Pharmaceutical Co., Ltd.), normal saline for injection (purchased from Shijiazhuang No.4 Medicine Co., Ltd.), disinfectant (84 disinfectant and 75% alcohol), etc.

[0030] 3) Virus: EV71 HFMD virus BJ09 / 07 strain (GenBank: JQ319054.1), isolated from clinical samples of children with HFMD.

[0031] 4) Experimental animals: SPF grade 7-day-old ICR suckling female mice, purchased from the Experimental Animal Center of the Academy...

Embodiment 2

[0044] Example 2: Xiyanping can treat the death of suckling mice caused by EV71 hand, foot and mouth disease virus BJ09 / 07 strain infection

[0045] Experimental Materials:

[0046] 1) Main experimental equipment: Class II biological safety cabinet, mouse breeding cage, sterile syringe, etc.

[0047] 2) Main experimental reagents: Xiyanping, saline control for injection, disinfectant, etc.

[0048] 3) Virus: EV71 type hand, foot and mouth disease virus strain BJ09 / 07.

[0049] 4) Experimental animals: SPF grade 7-day-old ICR suckling female mice, purchased from the Experimental Animal Center of the Academy of Military Medical Sciences.

[0050] experimental method:

[0051] 1) Grouping: Xiyanping treatment group, normal saline control group;

[0052] 2) Safely fix the suckling rats, keep the suckling rats with their heads down and their abdomens facing outwards, inject EV71 type hand, foot and mouth disease BJ09 / 07 virus liquid intraperitoneally with a sterile insulin syri...

Embodiment 3

[0062] Example 3: Xiyanping can relieve the pathological damage of brain tissue and muscle tissue of suckling mice caused by EV71 type hand, foot and mouth disease virus BJ09 / 07 strain infection

[0063] Experimental Materials:

[0064] 1) Main experimental instruments: Class II biological safety cabinets, mouse cages, sterile syringes, small animal surgical instruments, tissue slicers, tissue embedding machines, microscopes, etc.

[0065] 2) Main experimental reagents: Xiyanping, normal saline control for injection, paraformaldehyde fixative, sterile PBS, disinfectant, etc.

[0066] 3) Virus: EV71 type hand, foot and mouth disease virus strain BJ09 / 07.

[0067] 4) Experimental animals: SPF grade 7-day-old ICR suckling female mice, purchased from the Experimental Animal Center of the Academy of Military Medical Sciences.

[0068] experimental method:

[0069] 1) Grouping: Xiyanping prevention group, normal saline control group;

[0070] 2) Inject Xiyanping or normal saline...

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Abstract

The invention relates to a new drug using present antibiosis and antiphlogosis drug andrographolide and its derivative to prevent and treat the hand-foot-and-mouth disease, and provides a new uses of andrographolide drugs. The invention concretely relates to a use of the andrographolide drugs in the preparation of drugs for preventing and / or treating hand-foot-and-mouth disease virus infection. Pharmacodynamics researches on the andrographolide drugs, such as andrographolide, neoandrographolide, sulfonated andrographolide, triacetyl andrographolide and dehydroandrograpolide succinate show that andrographolide and its derivative are high efficiency drugs for preventing and treating the hand-foot-and-mouth disease, can be processed to prepare various common dosage forms used for clinical prevention and treatment, and have the characteristics of good curative effect, low toxicity and low price. A new drug is provided for the prevention and treatment of clinic hand-foot-and-mouth disease patients, and important bases are provided for finding a new theory and a new drug action target.

Description

technical field [0001] The invention relates to the application of andrographolide drugs in the preparation of drugs for treating and / or preventing virus infection of hand, foot and mouth disease, and belongs to the field of traditional Chinese medicine. Background technique [0002] Hand, foot and mouth disease is caused by viruses of the family Picornaviridae and the genus Enterovirus, and has become an important infectious disease that endangers the health of infants and young children and public health safety. HFMD is mainly caused by Enterovirus 71 (EV71) and Coxsackievirus A16 (Coxsackievirus A16, CA16). Hand, foot and mouth disease is usually a transient infection. It takes 3-6 days from infection to the appearance of clinical symptoms. Papules and herpes often appear on the hands, feet, and mouth. 3-year-old infants and young children will have serious complications, such as viral meningitis, encephalitis, paralysis similar to polio, and myocarditis, pericarditis, c...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/365A61P31/14
Inventor 赵忠鹏王希良任忠义谢宁管晨王玉光
Owner MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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