Induced pluripotent stem cell colony quality automatic evaluation method and device

A technology for automatic assessment of pluripotent stem cells, applied in the field of automatic assessment of colony quality of induced pluripotent stem cells, can solve the problems of uneven contrast and brightness, small image differences, and low performance of iPSCs colony quality assessment, so as to improve accuracy and save costs , the effect of improving the classification performance

Active Publication Date: 2020-12-18
SHENZHEN UNIV
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Problems solved by technology

[0004] Based on this, it is necessary to provide an automatic evaluation method and device for the quality of iPSCs colonies in order to solve the technical problems in the exist

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  • Induced pluripotent stem cell colony quality automatic evaluation method and device
  • Induced pluripotent stem cell colony quality automatic evaluation method and device
  • Induced pluripotent stem cell colony quality automatic evaluation method and device

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[0061] The present application provides a method and device for automatically evaluating the colony quality of induced pluripotent stem cells. In order to make the purpose, technical solution and effect of the present application clearer and clearer, the present application will be described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described here are only used to explain the present application, not to limit the present application.

[0062] Those skilled in the art will understand that unless otherwise stated, the singular forms "a", "an", "said" and "the" used herein may also include plural forms. It should be further understood that the word "comprising" used in the specification of the present application refers to the presence of the features, integers, steps, operations, elements and / or components, but does not exclude the presence or addition of one or more other features, Integers, s...

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Abstract

The invention provides an induced pluripotent stem cell colony quality automatic evaluation method and device; image preprocessing is carried out through adaptive gamma transformation, so the problemsof poor image brightness and contrast caused by objective reasons in the image acquisition process are solved; and based on rotation invariance of iPSCs colonies, the data set amplification is carried out through image rotation, mirroring and affine transformation; more comprehensive characteristic value information of iPSCs bacterial colony images is obtained by fusing characteristic informationof seven different sources, the classification performance is improved, the bacterial colony quality evaluation performance is improved, characteristic learning is carried out through a dimension reduction algorithm, the cost is saved, and application and popularization are facilitated.

Description

technical field [0001] The present application relates to the technical field of biological imaging, in particular to a method and device for automatically evaluating the colony quality of induced pluripotent stem cells. Background technique [0002] Induced pluripotent stem cells (iPSCs) are the basis for the development of regenerative medicine, but their quality restricts their development in the fields of medicine and biology. There are "good" and "bad" differences in the quality of mature induced pluripotent stem cell colonies, but high-efficiency automatic evaluation through morphological methods will face the following challenges: difficulty in distinguishing small differences, uneven contrast and brightness, and high manual evaluation costs. [0003] Therefore, the prior art still needs to be improved and improved. Contents of the invention [0004] Based on this, it is necessary to provide an automatic evaluation method and device for the quality of induced pluri...

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Application Information

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IPC IPC(8): G06T7/00G06T3/60G06T5/00G06K9/62G06N3/04G06N3/08
CPCG06T7/0012G06T5/007G06T3/60G06N3/08G06T2207/10056G06T2207/20221G06T2207/30204G06N3/045G06F18/2411
Inventor 汪天富雷柏英周光前岳广辉王永军廖进齐
Owner SHENZHEN UNIV
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