Application of Msi1 in preparation of gastric cancer treating preparation and prediction of tolerance of chemotherapy drug

Abstract

The invention discloses application of Msi1 in preparation of a gastric cancer treating preparation and prediction of tolerance of a chemotherapy drug. MSI1 protein is abnormally expressed in malignant tumor cells, and has important significance in mediating proliferation of tumor cells and causing the gastric cancer cells to be resistant to chemotherapy. However, the effect of the Msi1 protein ingastric cancer is studied by using a traditional in-vitro cell tumor-forming model, and the prediction effect of the Msi1 protein on the clinical drug curative effect is greatly reduced due to the fact that the cell line usually loses the molecular characteristics of the source tumor tissue and the tumor heterogeneity. A PDTX naked mouse model can well overcome the defect, and the curative effectof tumor drugs can be predicted more accurately. The invention aims to evaluate the relationship between the copy number of the MSI1 gene in the tumor tissue of a gastric cancer patient and the prognosis of clinical chemotherapy drugs by establishing a gastric cancer PDTX model, and guide individualized treatment of the gastric cancer patient.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an application of Msi1 in the preparation of preparations for treating gastric cancer and the prediction of resistance to chemotherapeutic drugs. Background technique [0002] It is known that MSI1 protein is abnormally expressed in malignant tumor cells, and plays an important role in mediating the proliferation of tumor cells and causing gastric cancer cells to resist chemotherapy. However, using the traditional in vitro cell tumorigenesis model to study the role of Msil protein in gastric cancer, the cell line has usually lost the molecular characteristics and tumor heterogeneity of the source tumor tissue, which will greatly reduce its predictive effect on clinical drug efficacy . The PDTX nude mouse model can well make up for this defect, and can more accurately predict the efficacy of tumor drugs. [0003] Gastric cancer is one of the most common malignancies of the di...

AI Technical Summary

Problems solved by technology

[0006] Technical problem to be solved: Aiming at the above-mentioned existing in vitro cell tumorigenesis models that have usually lost the molecular characteristics and tumor heterogeneity of the source tumor tissue, resulting in a greatly reduced prediction effect on clinical drug efficacy and other technical problems, the purpose of the present invention is to One is to provide an application of Msi1 in the preparation of preparations for the treatment of gastric cancer and the prediction of resistance to chemotherapy drugs

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