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Method for establishing hepatocellular carcinoma postoperative risk assessment model

A risk assessment model, a technology for hepatocellular carcinoma, applied in biochemical equipment and methods, microbial determination/examination, health index calculation, etc., to increase prediction accuracy and clinical net benefit, improve postoperative management and survival time Effect

Pending Publication Date: 2021-02-05
JUSBIO SCI SHANGHAI CO LTD
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Problems solved by technology

[0004] The metabolic enzymes and mediator molecules involved in many metabolic processes encoded by various metabolism-related genes play a key role in the progression of tumors. Gradually, studies have reported that cancer prognosis prediction models based on metabolism-related genes have been constructed, but in the liver In cell carcinoma, there are few prognostic models based on metabolism-related genes to predict the survival risk of patients after surgery and reflect the metabolic state in the tumor

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  • Method for establishing hepatocellular carcinoma postoperative risk assessment model
  • Method for establishing hepatocellular carcinoma postoperative risk assessment model
  • Method for establishing hepatocellular carcinoma postoperative risk assessment model

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Embodiment

[0044] 1. Select research objects:

[0045] The research object of this embodiment is the tumor tissue of 584 patients with hepatocellular carcinoma, and the inclusion and exclusion criteria are:

[0046] (1) Radical resection, and postoperative pathological diagnosis of hepatocellular carcinoma;

[0047] (2) Have not received other cancer treatment before operation;

[0048] (3) No history of other malignant tumors;

[0049] (4) Have complete clinicopathological data and follow-up information.

[0050] 2. Research methods:

[0051] (1) 584 cases of hepatocellular carcinoma tumor tissue samples were randomly divided into training set and verification set, including 342 cases in the training set and 242 cases in the verification set. The extracted tumor tissue RNA was subjected to transcriptome sequencing.

[0052] (2) Download the metabolism-related gene set from the Molecular Signatures Database website. In the training set, the correlation between each metabolism-relat...

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Abstract

The invention discloses a method for establishing a hepatocellular carcinoma postoperative risk assessment model, the model comprises 10 metabolism-related gene calculation items, the sum of the expression level of each gene weighted by a corresponding coefficient is used as a risk score, the risk of poor postoperative overall survival of a patient can be judged, and tumor metabolism characteristics are reflected.

Description

technical field [0001] The invention belongs to the field of gene detection, and in particular relates to a method for establishing a postoperative risk assessment model of hepatocellular carcinoma, and also relates to the application of the established postoperative risk assessment model of hepatocellular carcinoma in a gene detection device. Background technique [0002] The prevalence of liver diseases related to metabolic disorders represented by non-alcoholic liver disease has led to a continuous increase in the incidence of hepatocellular carcinoma worldwide, ranking first among all cancers. Statistics from the National Cancer Center of my country show that the incidence of liver cancer ranks fourth among cancers, and it is also the fifth leading cause of cancer-related death. Late diagnosis and postoperative high-frequency recurrence are the main reasons for the poor prognosis of patients with liver cancer, but the existing clinical prognostic indicators such as alpha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16B25/00G16B30/00G16B40/00C12Q1/6886
CPCG16H50/30G16B25/00G16B30/00G16B40/00C12Q1/6886C12Q2600/158C12Q2600/118C12Q2600/112
Inventor 任宁周晨浩翁佳雷易勇周强孙嘉磊陈万勇尹毅锐
Owner JUSBIO SCI SHANGHAI CO LTD
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