GLI protein inhibitor and application thereof

A technology of protein inhibitors and inhibitors, applied in the field of bioengineering, can solve the problem of unclear induction of CD90 stem cell-like cells

Pending Publication Date: 2021-03-09
SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Aiming at the deficiencies of the prior art, the present invention provides a GLI protein inhibitor and its application, which solves the problem of whether GLI1 / 3 induces CD90 stem cell-like cells in tumors among the existing GLI protein inhibitors, and CD90 is in the The role in the tumor microenvironment and whether it can be realized through the interaction with IL-6, and whether the promotion of GLI1 / 3's expression of IL-6 and CD90 provides the adaptation conditions of the tumor cell microenvironment and the basis of tumor proliferation and metastasis

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  • GLI protein inhibitor and application thereof
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  • GLI protein inhibitor and application thereof

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Embodiment Construction

[0043] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0044] see Figure 1-9 , the embodiment of the present invention provides a technical solution: a GLI protein inhibitor, the GLI protein inhibitor is an inhibitor made of GLI1 / 3 antibody protein.

[0045] The embodiment of the present invention also discloses the application of a GLI protein inhibitor in the treatment of liver cancer. By using the GLI protein inhibitor, GLI1 / 3 can be down-regulated to inhibit the transcription of CD90, and the secretion of IL-...

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Abstract

The invention discloses a GLI protein inhibitor and application thereof. The GLI protein inhibitor is an inhibitor prepared from GLI1/3 antibody protein. According to the GLI protein inhibitor and theapplication thereof, the promotion effect of GLI1/3 on CD90+ cells in hepatocellular carcinoma and the promotion effect on cancer in a tumor microenvironment are clarified, the viewpoint that IL-6 regulates a JAK/STAT3 pathway in the hepatocellular carcinoma microenvironment in a brand-new action mode is proposed and illustrated, the theoretical basis that CD90 cells in the tumor microenvironmentserve as tumor process markers is evaluated, thus the induction of the GLI1/3 on CD90 stem cell-like cells in tumors is clarified, and the action of CD90 in the tumor microenvironment and the interaction with IL-6 can be realized.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to a GLI protein inhibitor and its application. Background technique [0002] Liver cancer is a refractory malignant tumor with strong heterogeneity and high mortality. Primary liver cancer includes hepatocellular carcinoma (HCC), cholangiocellular carcinoma and mixed liver cancer, and HCC accounts for 85-90%. The main causes of liver cancer are long-term liver damage caused by viral infection and metabolic diseases. Hepatitis B virus (HBV) and hepatitis C virus (HCV) lead to continuous progression and malignant transformation of chronic liver inflammation, which can induce liver cancer; in recent years, including non-alcoholic metabolic diseases Chronic hepatitis caused by metabolic liver diseases including chronic liver diseases is increasing year by year, becoming another important cause of chronic hepatitis. Chronic persistent HBV infection is the most important risk fact...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P35/00A61P35/04C12Q1/02G01N33/68G01N33/574
CPCA61K39/39533A61P35/00A61P35/04C07K16/18G01N33/5011G01N33/5041G01N33/5038G01N33/6869G01N33/68G01N33/57438G01N33/57484C07K2317/73G01N2333/5412G01N2333/70503
Inventor 刘尊龙任飞刘建平
Owner SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV
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