Medical stent for digestive system and manufacturing method thereof

Abstract

A medical stent for the digestive system, which is obtained by 3D printing of degradable polymer materials. It includes at least two continuous layers of three-dimensional grid structures in the radial direction. The layered three-dimensional grid structure is compositely printed by a degradable polymer main material and at least one degradable polymer sub-material, and the degradable polymer sub-material is completely degraded earlier than the degradable polymer main material, and the inner layer In the three-dimensional grid structure, at least part of the degradable polymer main material is continuous in the axial direction of the entire medical stent and the extension area of ​​the radial section of the inner three-dimensional grid structure is not less than that of the inner three-dimensional grid structure 20% of the total radial cross-sectional area. The present invention manufactures the above-mentioned degradable medical stent by means of 3D printing technology, realizes fine-tuning of mechanical properties, control of drug release and degradation cycle through the planning of primary and secondary materials, and optimizes the overall performance of a more versatile digestive system medical stent.

Description

technical field [0001] The invention relates to the technical field of manufacturing medical materials, in particular to a medical bracket for digestive system and a manufacturing method thereof. Background technique [0002] Medical stents for the digestive system mainly refer to various gastrointestinal stents. At present, gastrointestinal stent implantation has been increasingly used for the treatment of patients with gastrointestinal stenosis or gastrointestinal obstruction. In clinical practice, according to the location of different lesions Inserting the corresponding digestive tract stent can effectively rebuild the patency of the digestive tract. Because of its simple operation and small trauma, it can be applied to the treatment of esophagus, stomach, duodenum, colorectum and bile duct. [0003] The most clinically used digestive tract stents are mainly non-degradable polymer materials such as polyethylene and some metal materials such as stainless steel and nickel-...

AI Technical Summary

Problems solved by technology

[0005] At present, some technologies have proposed that in the 3D printing process of digestive tract stents, different printing materials should be selected according to the characteristics of different segments of the digestive tract. Material elasticity and hardness are planned to adapt to the characteristics of the digestive tract of this segment, and the different requirements of the structure (such as expansion coefficient). However, because this technology needs to select materials strictly according to the structure of the individual digestive tract, it is generally impossible to conduct sufficient experimental verification on individual patients clinically. , its application is very limited

[0006] At present, the material planning method of 3D printing has not broken away from the limitation of the above-mentioned "functional partition" idea, and has not been well used to optimize the overall performance of the more general digestive system medical stent, especially not used to optimize the biodegradable high Study on the mechanical properties of molecular materials for digestive system scaffolds and their mode of action in the human body

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