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Traditional Chinese medicine composition for inhibiting early development and sexual precocity of children and preparation method and application of composition

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve the problems of inhibited growth group, high price, polycystic ovary syndrome and the like

Active Publication Date: 2021-03-16
上海艾育生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, biological products are mainly used in the treatment of precocious puberty in children. At present, the internationally recognized drug for the treatment of central precocious puberty is gonadotropin-releasing hormone analogue (GnRHa), but it is expensive. Generally, children will develop growth after 3-6 months of application. The group is inhibited, growth hormone must be injected at the same time, and it can also lead to polycystic ovary syndrome. Phytotherapy, can effectively inhibit the hypothalamus-pituitary-gonadal axis hyperactivity

Method used

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  • Traditional Chinese medicine composition for inhibiting early development and sexual precocity of children and preparation method and application of composition
  • Traditional Chinese medicine composition for inhibiting early development and sexual precocity of children and preparation method and application of composition
  • Traditional Chinese medicine composition for inhibiting early development and sexual precocity of children and preparation method and application of composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Inhibition of children's early development, Chinese medicine compositions of sexual premature, including 12.5 parts by weight of yellow sperm, 12.5 parts by weight of 苓, 12.5 parts by weight of gardenia, 55.0 parts by weight of malt.

[0029] Preparation:

[0030] The above herbs will be weighed according to the above ratios, and then placed in the extraction tank, remove impurities such as dust sandstone on the medicinal material, remove water and impurities, add 10 times water, boil and boil for 2 hours. After filtration, the liquid is obtained, and the filter residue is added to 6 times the amount of water, boil and boil for 1 hour, and the liquid liquid is filtered, and the liquid solution obtained twice will be combined, and the combined liquid is concentrated as a medicinal material: liquid liquid = 1 parts by mass: 6 parts by mass of concentrate.

[0031] Step 2, the concentrate obtained by the step 1 is filtered through a ceramic film to obtain a film filtrate, and ...

Embodiment 2

[0036] Inhibition of children's early development, Chinese medicine compositions of sexual early, including 20 parts by weight, 5 parts by weight of 苓, 20 parts by mass, gardenia, 88 parts by weight of malt.

[0037] Preparation:

[0038] The above herbs will be weighed according to the above ratios, and then placed in the extraction tank, remove impurities such as dust sandstone on the medicinal material, remove water and impurities, add 10 times water, boil and boil for 2 hours. After filtration, the liquid is obtained, and the filter residue is added to 6 times the amount of water, boil and boil for 1 hour, and the liquid liquid is filtered, and the liquid solution obtained twice will be combined, and the combined liquid is concentrated as a medicinal material: liquid liquid = 1 parts by mass: 10 parts by mass of concentrate.

[0039] Step 2, the concentrate obtained by the step 1 is filtered through a ceramic film to obtain a film filtrate, and the ceramic film aperture can pa...

Embodiment 3

[0044] Inhibition of children's early development, Chinese medicine compositions of sexual premature, including 5 parts by weight, 20 parts by weight of 苓, 5 parts by mass, gardenia, 22 parts by weight of malt.

[0045] Preparation:

[0046] The above-mentioned herbs will be weighed according to the above ratios, and then placed in the extraction tank, impurities such as dust sandstone on the medicinal material, remove water and impurities, and add 70% ethanol of all the medicinal materials, boil and boil. Boiling for 2 hours, the liquid is filtered, and the filter residue is added to 70% ethanol, boil and boil for 1 hour, filtrate to obtain a liquid, combined with the liquid solution obtained, and the combined liquid liquid The reduced pressure was concentrated and the ethanol was recovered, and the final liquid was concentrated as a medicinal material: the liquid = 1 parts by mass: 10 parts by mass of the concentrate.

[0047] Step 2, the concentrate obtained by the step 1 is fi...

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Abstract

The invention provides a traditional Chinese medicine composition for inhibiting early development and sexual precocity of children and a preparation method and application of the traditional Chinesemedicine composition. The traditional Chinese medicine composition is prepared from 5-20 parts of rhizoma polygonati, 5-20 parts of poria cocos, 5-20 parts of rhizoma dioscoreae, 3-12 parts of fructusgardeniae, and 22-88 parts of malt. The preparation method comprises the following steps: extracting the traditional Chinese medicine composition with water or ethanol, conducting concentrating, filtering with a ceramic membrane, sequentially adsorbing with a medium-polarity macroporous adsorption resin column and a polyamide column, eluting with water, and eluting with 40%-70% ethanol, collecting the eluent, concentrating the eluent under reduced pressure, and then spray-drying the concentrate to obtain a fine powder. The above traditional Chinese medicine composition is applied to medicineand food for inhibiting early development and sexual precocity of children, can inhibit early development and sexual precocity of children, and is low in price and free of side effects.

Description

Technical field [0001] The present invention belongs to the technical field of medicine, and more particularly to Chinese medicine compositions and preparation methods and methods of inhibiting childhood development and early maturity. Background technique [0002] Children have early development, sexual premature is abnormal due to child development, and cause endocrine disorders during the development of children. [0003] According to the Ministry of Health issued a premature diagnostic guide Trial: Childhood morning maturity: Boy is 9 years old, the girl is 8 years old, presenting the second sexy. According to the pathogenesis and clinical manifestations, generosity can be divided into central germoratrum and peripheral premature premature, and it is contemplated as a high premature premature and falsehood. In recent years, childhood has increased year by year, showing low-age, incidence rate, and 1.8% early development. [0004] Childhood premature is a worldwide disease, di...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P5/24A61P25/20A61P19/08A23L2/39A23L2/38A23L33/105A23L33/10
CPCA61K36/8969A61K36/076A61K36/8945A61K36/744A61K36/8998A61P5/24A61P25/20A61P19/08A23L2/39A23L2/38A23L33/105A23L33/10A61K2236/331A61K2236/33A61K2236/53A61K2236/51A61K2236/55A23V2002/00A61K2300/00A23V2200/30A23V2250/208A23V2250/21
Inventor 王珏邵旭
Owner 上海艾育生物科技有限公司
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