Composition of prodigiosin and oxacillin or derivatives thereof, use thereof and medicament containing same

A technology of oxacillin and prodigiosin, which is applied in the field of medicine and can solve problems such as affecting the treatment effect of patients, decreasing sensitivity, and recurrent disease
CN112587525BActive Publication Date: 2022-02-08ZHUHAI INST OF ADVANCED TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHUHAI INST OF ADVANCED TECH
Publication Date
2022-02-08

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Abstract

The invention relates to a composition of prodigiosin and oxacillin or its derivatives, wherein the mass ratio of prodigiosin and oxacillin or its derivatives is 1 to 2.55:1, and the invention also provides the above-mentioned The composition is used in preparing and treating infectious diseases of methicillin-resistant staphylococcus aureus, and provides a medicine for treating infectious diseases of methicillin-resistant staphylococcus aureus. The composition of the invention and the medicine containing the composition have significantly higher antibacterial effect than the single components of the two.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a composition of prodigiosin, oxacillin or derivatives thereof, its application and the medicine containing it. Background technique

[0002] Prodigiosins (PG) is a natural red pigment with a polypyrrole ring, which is a secondary metabolite produced by some actinomycetes, Serratia and other bacteria. It was first discovered by Amok and Harashima in 1929. It is isolated from Serratia marcescens. In recent years, many scholars have found that prodigiosin is a very potential antibacterial drug. Antibacterial tests in vitro show that prodigiosin has good antibacterial effect on Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, etc., and has certain drug potential.

[0003] Methicillin-resistant Staphylococcus aureus (MRSA) is one of the main pathogens of hospital and community infections, often causing acute suppurative pneumonia in adults and children. Methicillin-re...

Claims

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