miRNA kit for detecting prognosis of lung adenocarcinoma
A detection reagent, a technology for lung adenocarcinoma, which can be used in DNA/RNA fragments, recombinant DNA technology, and microbial determination/inspection, etc., and can solve problems such as unreported miRNA kits
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[0025]Example 1 Screening and effect verification of genomic
[0026](1) Construction of prognostic score model of lung adenocarcinoma
[0027]1 method
[0028]We first obtain 61 genome knockout of the total genome knockout from the DEPMAP database, 400 genes related to cell proliferation significantly related to cell proliferation. At the same time, we analyzed these gene expression data in the TCGA database to obtain 429 lung adenocarcinoma samples, and further obtained genetically related to cell proliferation and prognosis by single factor Cox regression and Lasso regression, and finally selected six bases : PSMB6, HSPA9, FOLR2, DUT, CDK7, PLK1; Through multi-factor COX regression built score model score = -0.07371 × PSMB6 + 0.23058 × FOLR2 + 0.14739 × DUT + 0.17565 × CDK7 + 0.26704 × PLK1. Based on this scoring model, we calculate the score of each sample. The truncation value is obtained by logistic regression, and the truncation value is 3.539, and the TCGA sample is divided into two ...
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