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Fatty liver tissue three-dimensional simulation model construction method

A technology of three-dimensional simulation and construction method, which is applied in 3D modeling, details related to 3D image data, image data processing, etc. It can solve the problems of inability to obtain the three-dimensional distribution of fat droplets, accurate quantitative interference of liver fat, and influence uniformity.

Active Publication Date: 2021-05-11
ANHUI MEDICAL UNIV
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Problems solved by technology

[0005] However, the above-mentioned medical imaging technology has the following challenges when measuring liver fat: (1) the two-dimensional distribution image of liver fat is obtained, and the three-dimensional distribution of fat droplet size cannot be obtained; (2) the content and distribution of fat in the liver are not Uniform, heterogeneous distribution of fat droplets can affect ultrasound propagation, X-ray attenuation, or magnetic field homogeneity, which in turn can produce different ultrasound, computed tomography, or magnetic resonance imaging signals, which interfere with accurate quantification of liver fat; (3 ) in the case of different degrees of hepatic steatosis, the morphological evolution of fat droplets is not clear, but it is of great significance for understanding the deposition and metabolism mechanism of fat droplets in the hepatic cytoplasm

Method used

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  • Fatty liver tissue three-dimensional simulation model construction method
  • Fatty liver tissue three-dimensional simulation model construction method

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Embodiment 1

[0058] A method for constructing a three-dimensional simulation model of fatty liver tissue, such as figure 1 As shown, the steps involved are:

[0059] Step 1, staining the liver biopsy sample;

[0060] Step 2. Obtain a histogram of the two-dimensional size distribution of the real fat droplet and a two-dimensional nearest neighbor distance distribution histogram of the real fat droplet according to the statistics of the liver biopsy sample;

[0061] Step 3, calculating the histogram of the three-dimensional size distribution of fat droplets according to the histogram of the two-dimensional size distribution of the real fat droplets obtained in step two;

[0062] Step 4. Construct a plurality of grid points of the shape parameters and scale parameters of the three-dimensional nearest neighbor distance distribution of fat droplets, and combine the three-dimensional size distribution histogram of fat droplets obtained in step three to construct multiple three-dimensional simul...

Embodiment 2

[0099] A method for constructing a three-dimensional simulation model of fatty liver tissue, illustrated by three liver samples with different fat contents.

[0100] Step one includes:

[0101] Step 1.1. Collect 3 liver tissue samples according to clinical routine, the section thickness is 5um, stain with H&E, and the fat content of the biopsy samples are 2.46%, 7.24% and 20.80% respectively;

[0102] Step 1.2, perform image binarization processing on 3 liver tissue samples, such as figure 2 and 3 . Specifically, the fat droplet is approximated as a circle with the same area and the same center of gravity in a two-dimensional plane, so as to count the two-dimensional size of the fat droplet and the two-dimensional nearest neighbor distance information.

[0103] Step 2: Statistically calculate the distribution histograms of the two-dimensional size of the fat droplet and the two-dimensional nearest neighbor distance in each biopsy sample image, and the group distance is 1um...

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Abstract

The invention discloses a fatty liver tissue three-dimensional simulation model construction method. A three-dimensional simulation model is obtained through six steps. According to the fatty liver tissue three-dimensional simulation model construction method, three-dimensional simulation models under different liver fat contents can be obtained. The fatty liver tissue three-dimensional simulation model construction method can evaluate the three-dimensional distribution of the fat droplets in the cytoplasm with different fat contents according to the fat droplet scale.

Description

technical field [0001] The invention relates to the technical field of three-dimensional simulation model construction, in particular to a three-dimensional simulation model construction method of fatty liver tissue. Background technique [0002] Fatty liver is the excessive accumulation of fat in the liver caused by various reasons, and it is usually the pathological manifestation of diffuse liver disease, which may lead to serious complications such as liver fibrosis, liver cirrhosis and even liver failure. According to the "Guidelines for the Prevention and Treatment of Fatty Liver in China" issued by the Chinese Medical Association Hepatology Branch and the Fatty Liver Expert Committee of the Chinese Medical Doctor Association in 2015, fatty liver has become the number one liver disease in my country, and the prevalence of fatty liver in adults ranges from 12.5% ​​to 35.4%. %, and patients with fatty liver showed a younger trend. [0003] According to the shape of fat dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T17/00G06T5/40
CPCG06T17/00G06T5/40G06T2200/04G06T2207/30056
Inventor 王常青王金洋吴茜杨飞胡孝朋
Owner ANHUI MEDICAL UNIV
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