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Organ perfusion and preservation solution and application thereof

An organ perfusion and solution technology, applied in the field of organ transplantation, can solve problems such as organ damage and poor fluidity, and achieve the effects of reducing damage, good fluidity and good antioxidant properties

Active Publication Date: 2022-04-22
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] The purpose of the present invention is to provide an organ perfusion and preservation solution to solve the problem of poor fluidity of the existing mechanical perfusion fluid and easily cause organ damage, and has the advantages of prolonging organ preservation and transportation time and improving organ quality

Method used

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  • Organ perfusion and preservation solution and application thereof
  • Organ perfusion and preservation solution and application thereof
  • Organ perfusion and preservation solution and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Organ perfusion and preservation solution, in terms of 1 L solution, the perfusion and preservation solution consists of the following components:

[0049] Lactosauronic acid 95mM, potassium dihydrogen phosphate 24mM, adenine 4mM, reduced glutathione 4mM, acetaminophen 4mM, iramide 5mM, allopurinol 0.5mM, sodium gluconate 75mM, magnesium gluconate 4mM, potassium phosphate 20mM, dexamethasone 16mg / L, superbranched polyglycerol and water for injection, the amount of superbranched polyglycerol is to perfuse and preserve the osmotic pressure of the solution to regulate 310mOsm / L, The pH of the perfusion and preservation solution was adjusted to 7.15±0.10 by using hydrochloric acid / sodium hydroxide.

[0050] The preparation process of the perfusion and preservation solution described in the present embodiment is as follows:

[0051] All components were added to a certain amount of water for injection in turn, and the pH and osmotic pressure were adjusted by using hydrochloric ...

Embodiment 2

[0053] Organ perfusion and preservation solution, in terms of 1 L solution, the perfusion and preservation solution consists of the following components:

[0054] Lactosalic acid 105mM, potassium dihydrogen phosphate 26mM, adenine 6mM, reduced glutathione 6mM, acetaminophen 6mM, eraramide 5mM, allopurinol 1.5mM, sodium gluconate 85mM, magnesium gluconate -6mM, potassium phosphate 25mM, dexamethasone 16mg / L, superbranched polyglycerol and water for injection, the amount of superbranched polyglycerol is to perfuse and preserve the osmotic pressure of the solution to regulate 310mOsm / L, The pH of the perfusion and preservation solution is 7.15±0.10.

Embodiment 3

[0056] Organ perfusion and preservation solution, in terms of 1 L solution, the perfusion and preservation solution consists of the following components:

[0057]Lactosalic acid 100mM, potassium dihydrogen phosphate 25mM, adenine 5mM, reduced glutathione 5mM, acetaminophen 5mM, iramide 5mM, allopurinol 1.0mM, sodium gluconate 80mM, magnesium gluconate 5mM, potassium phosphate 20mM, dexamethasone 16mg / L, superbranched polyglycerol and water for injection, the amount of superbranched polyglycerol is the osmotic pressure of the perfusion and preservation solution to regulate 310mOsm / L, The pH of the perfusion and preservation solution is 7.15±0.10.

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Abstract

The invention discloses an organ perfusion and preservation solution and application thereof. The perfusion and preservation solution uses hyperbranched polyglycerol as an osmotic pressure regulator, uses acetaminophen and iramitide as antioxidants, and does not contain hydroxyethyl starch. By adding hyperbranched polyglycerol, acetaminophen and iramitide to the perfusion and preservation solution of the present invention, not only the fluidity and anti-oxidation properties are effectively improved, but also the mitochondria in ischemia-reperfusion injury can be protected. , which has the advantages of prolonging the preservation and transportation time of organs and improving the quality of organs.

Description

Technical field [0001] The present invention relates to the field of organ transplantation technology, specifically to an organ perfusion and preservation solution and its applications. Background [0002] Currently, transplantation is the treatment of choice for organ failure. Studies have shown that ischemia-reperfusion injury after transplantation of donor organs is an important factor affecting transplant prognosis. Therefore, it is very important to develop and improve organ protection fluids. At present, there are a variety of organ preservation solutions on the market, such as Collins solution, University of Wisconsin solution (UW solution), histidine-tryptophan-ketoglutarate solution (HTK solution) and so on. These organ preservation solutions promote the rapid development of static cold preservation technology of organs, so that organ preservation can get rid of time and geographical restrictions to a certain extent. Static cold preservation technology is still the most...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
CPCA01N1/0221A01N1/0226A01N1/021
Inventor 冯师健
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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