Multi-dimensional optical tweezers calibration device and method based on electric field quantity calibration

A technology of calibration device and calibration method, applied in the field of sensor calibration, can solve the problems of error, calibration difficulty, particle delivery, optical monitoring difficulty, etc., and achieve the effects of simple device, low calibration difficulty and wide application range

Active Publication Date: 2021-05-28
ZHEJIANG LAB +1
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Problems solved by technology

Due to the difficulty of thermal balance calibration under high vacuum, thermal balance calibration is often carried out at a vacuum above 1mbar, and the calibration results may introduce errors when applied to high vacuum
The electric field force calibration method can also be calibrated and calibrated without being affected by the degree of vacuum, but the existing technology for calibrating the three-axis motion signal of particles is realized by loading electrode plates on six sections around the microspheres. The three-dimensional electric field device thus constituted leads to Particle delivery, optical monitoring becomes difficult

Method used

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  • Multi-dimensional optical tweezers calibration device and method based on electric field quantity calibration
  • Multi-dimensional optical tweezers calibration device and method based on electric field quantity calibration
  • Multi-dimensional optical tweezers calibration device and method based on electric field quantity calibration

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Embodiment Construction

[0025] The present invention will be described in detail below with reference to the accompanying drawings and preferred embodiments, and the purpose and effect of the present invention will become clearer. It should be understood that the specific embodiments described here are only used to explain the present invention and are not intended to limit the present invention.

[0026] Such as figure 1 As shown, the multi-dimensional optical tweezers calibration device based on electric field calibration of the present invention includes a laser 1, a beam splitter 2, a polarization adjuster 3, a vacuum cavity 4, an objective lens 5, a parallel electric field application unit 7, and an electric field control unit 8 , the first photodetector 9, the second photodetector 10, the data processor 11;

[0027] The beam splitter 2, the polarization adjuster 3, the objective lens 5, the parallel electric field application unit 7 and the first photodetector 9 are sequentially arranged on the...

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Abstract

The invention discloses a multi-dimensional optical tweezers calibration device and method based on electric field quantity calibration, and provides a one-dimensional electric field calibration device to realize three-axis electric field force calibration of particles by utilizing the polarization dependence characteristic of a tight focusing light trap. According to the method, a particle electric field force calibration system is compatible with a particle delivery and particle detection system; the complexity of the device is simplified, and the calibration complexity is weakened.

Description

technical field [0001] The invention relates to the field of sensor calibration, in particular to a multi-dimensional optical tweezers calibration device and method based on electric field calibration. Background technique [0002] Since the optical tweezers technology was pioneered by Arthur Ashkin in the 1970s, as a general tool for trapping and manipulating neutral particles, it has been widely studied and applied in the fields of molecular biology, nanotechnology and experimental physics. The optical tweezers technology can be understood by the simple harmonic oscillator model through the suspended particles of the laser beam. Compared with the traditional oscillator model, the optical tweezers technology has no contact mechanical dissipation; further, unlike the optical tweezers system in the liquid or air medium, it operates in a vacuum The optical tweezers system can realize the complete isolation of the suspended unit from the environment. Based on the above advanta...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G21K1/00G01B7/02G01B21/04G02B27/28
CPCG21K1/006G01B7/02G01B21/042G02B27/28G01N2015/0038G01N15/1434G01N15/1456G01N2015/0046G02B5/3083G02B27/286
Inventor 李翠红陈志明蒋静高晓文傅振海胡慧珠
Owner ZHEJIANG LAB
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