A kind of traditional Chinese medicine compound preparation for treating liver cancer and its application

A compound preparation, a technology for treating liver cancer, applied in pharmaceutical formulations, medical preparations containing active ingredients, anti-tumor drugs, etc. Non-response and drug resistance

Active Publication Date: 2021-12-17
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

HCC is highly resistant to chemotherapy drugs. Targeted drugs Sorafenib and Regorafenib developed in recent years have been listed as first-line and second-line systemic therapy for advanced HCC. The improvement in patient survival was less than 3 months
Moreover, these targeted drugs and chemotherapy drugs have a large number of patients who do not respond and drug resistance, and all have serious skin and intestinal side effects
Although great progress has been made in the diagnosis and treatment of liver cancer in recent years, the goal of basic control of the disease is still far from being achieved

Method used

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  • A kind of traditional Chinese medicine compound preparation for treating liver cancer and its application
  • A kind of traditional Chinese medicine compound preparation for treating liver cancer and its application
  • A kind of traditional Chinese medicine compound preparation for treating liver cancer and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh the raw materials according to the following weights: 12g heterophylla, 12g fried Atractylodes macrocephala, 12g poria cocos, 5g dried tangerine peel, 9g northern root, 9g asparagus, 15g raw astragalus, 9g angelica, 5g Tianlong, 9g Zhinanxing, 9g curcuma, and Shishangbai 15g, 15g of hibiscus leaves, prepared into decoction, granule, tablet, capsule or oral liquid according to the conventional process.

Embodiment 2

[0039] Weigh raw materials according to the following weights: 15g heterophylla, 15g fried Atractylodes macrocephala, 15g poria cocos, 6g dried tangerine peel, 9g northern root, 9g asparagus, 30g raw astragalus, 12g angelica, 5g Tianlong, 9g Zhinanxing, 9g zedoary, and Shishangbai 15g, 15g of hibiscus leaves, prepared into decoction, granule, tablet, capsule or oral liquid according to the conventional process.

Embodiment 3

[0041] Weigh raw materials according to the following weight: 12g heterophylla, 12g fried Atractylodes macrocephala, 12g poria cocos, 5g tangerine peel, 12g Adenophora radix, 12g asparagus, 15g raw astragalus, 9g angelica, 5g Tianlong, 9g zhinanxing, 9g zedoary, and Shishangbai 15g, 15g of hibiscus leaves, prepared into decoction, granule, tablet, capsule or oral liquid according to the conventional process.

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Abstract

The invention discloses a compound preparation for treating liver cancer, which is innovative in that it is prepared from the following raw materials in parts by weight: 9-15 parts of heterophylla, 9-15 parts of fried Atractylodes macrocephala, 9-15 parts of poria cocos, tangerine peel 3 to 6 parts, 6 to 12 parts of Adenophora, 6 to 12 parts of Asparagus, 12 to 30 parts of Raw Astragalus, 6 to 12 parts of Angelica, 3 to 6 parts of Tianlong, 6 to 12 parts of Zhinanxing, 6 to 12 parts of Curcuma 12-30 parts of cypress, 12-30 parts of hibiscus leaves. The compound preparation of the present invention can be made into tablets, granules, capsules or oral liquids by conventional methods. Pharmacodynamics shows that the compound preparation of the present invention alone or in combination with other liver cancer targeting drugs or chemotherapy drugs can improve the general condition of liver cancer patients and inhibit tumor growth, metastasis and recurrence.

Description

technical field [0001] The invention belongs to the field of research, development and utilization of traditional Chinese medicine, in particular to a compound Chinese medicine preparation for treating liver cancer and its application. Background technique [0002] Liver cancer is a common malignant tumor that is difficult to diagnose and treat and has a very poor prognosis. Among them, hepatocellular carcinoma (HCC) is the most common type, accounting for about 70-85%. Its incidence rate ranks fifth among tumors, and its case fatality rate ranks third. Hepatitis B virus infection and aflatoxin are the main causes of HCC. In recent years, due to hepatitis C virus infection and obesity, the incidence rate in European and American countries has increased significantly. The epithelial-to-mesenchymal transition (EMT) of tumor cells is an important reason for the increase of the malignant degree of liver cancer, which is related to the metastasis, recurrence and drug resistance ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K36/9066A61P35/00A61K35/583A61K35/648
CPCA61K36/36A61K36/284A61K36/076A61K36/752A61K36/23A61K36/8965A61K36/481A61K36/232A61K35/648A61K36/8884A61K36/9066A61K36/11A61K36/185A61K35/583A61P35/00A61K2300/00
Inventor杨金祖宋海燕马耀凯汤凯悦
OwnerLONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE