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Magnetic particle and method

A technology of magnetic particles and particles, applied in the direction of magnetic objects, magnetic thin films, conductive/insulating/magnetic materials on magnetic films, etc., can solve problems such as troubles and limited number of multiplexing

Pending Publication Date: 2021-06-22
CAMBRIDGE ENTERPRISE LTD
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  • Summary
  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In practice, however, these systems suffer from limited multiplexing (the limited number of different proteins that can be identified) due to their limited ability to deterministically partition between multiple channels in the assay results

Method used

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  • Magnetic particle and method
  • Magnetic particle and method
  • Magnetic particle and method

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Embodiment Construction

[0069] Specific embodiments of the present invention relate to the fabrication of high magnetic moment particles made from ultrathin perpendicularly magnetized CoFeB / Pt layers. The high aspect ratio of the shape of these particles results in an extremely low stray magnetic field from each particle, such that the magnetic nanoparticles show no interparticle interactions (and thus no agglomeration). When an external magnetic field is applied, the particles transition to magnetic saturation with forced snap switching and remain completely. Individual barcodes are added to the particles using a simple and robust photolithographic process and can be read optically. As described below, robust multiplexed assays (eg, cytokine assays) using magnetic particles have been demonstrated highlighting their potential for assay applications.

[0070] In embodiments, photolithographically produced magnetic particles can advantageously achieve high magnetic moments, no interparticle interactio...

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Abstract

A magnetic particle (30, 70) has a layered structure (6, 56) between a top surface of the particle and an opposed bottom surface of the particle. Layers of the structure include one or more nonmagnetic layer(s) and one or more magnetized layer(s). The ratio of a lateral dimension of the one or more magnetized layers to the aggregate thickness of the magnetized layer or layers is greater than 500. A plurality of such magnetic particles (30, 70) can be functionalised and marked with readable codes (16, 66) corresponding to the functionalisation, for use for performing assays such as bioassays.

Description

technical field [0001] The present invention relates to a magnetic particle, and methods of making and using the magnetic particle. Background technique [0002] The technique of exerting mechanical forces on individual magnetic particles using an applied field has been exploited in various biotechnological applications. [0003] An important commercial use of magnetic nanoparticles and microparticles is currently in bioassays to separate and identify biomolecules. Superparamagnetic iron oxide nanoparticles (SPION) are commonly used in this range of commercial applications due to the property they provide to migrate towards an external magnetic field source. This enables the particle to be directed towards a desired location by applying an external magnetic field for reading the assay information. These particles are nanoparticles (5-20 nm in diameter) made by colloidal chemistry. The size of these particles is limited by the fact that if the particles are made larger tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F10/26G01N33/543H01F41/34
CPCH01F10/265H01F41/34G01N33/54326
Inventor J·费尔海恩T·维穆尔卡尔R·考伯恩
Owner CAMBRIDGE ENTERPRISE LTD
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