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Application of halcinonide and its derivatives in the preparation of medicines for treating and/or preventing cerebrovascular diseases

A drug and ischemic stroke technology, applied in the field of medicine, can solve the problems of cerebrovascular diseases without the application of halcinonide, achieve good application prospects, improve the score, and reduce the area

Active Publication Date: 2022-02-08
上海普佑生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no literature on the application of halcinonide to cerebrovascular diseases, nor any literature suggesting that halcinonide has the function of treating cerebrovascular diseases

Method used

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  • Application of halcinonide and its derivatives in the preparation of medicines for treating and/or preventing cerebrovascular diseases
  • Application of halcinonide and its derivatives in the preparation of medicines for treating and/or preventing cerebrovascular diseases
  • Application of halcinonide and its derivatives in the preparation of medicines for treating and/or preventing cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1. Study on the Effect of Halcinonide in Treating Ischemic Stroke

[0070] 1. Experimental animals

[0071] 3-month-old SPF male SD rats were selected, with a body weight of 200±20g. Provided by Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences. No drugs were used before the experiment. The experimental animals were adapted to feeding for a week in an environment with a temperature of 24-26°C and a 12h / 12h regular alternation of day and night. The animals were given food and water freely, and then the experiments were performed in groups.

[0072] 2. Drugs and reagents

[0073] Halcinonide, purchased from Shanghai Macklin Biochemical Technology Co., Ltd., batch number: C11650940, molecular weight formula C 24 h 32 ClFO 5 , with a molecular weight of 454.96

[0074]Butylphthalide soft capsules (Butylphthalide, NBP), purchased from CSPC NBP Pharmaceutical Co., Ltd.;

[0075] 2,3,5-Triphenyltetrazolium chloride (TTC) was purcha...

Embodiment 2

[0101] Example 2. Study on the Effect of Prednisone in Treating Ischemic Stroke

[0102] 1. The specific implementation method is the same as embodiment one.

[0103] Prednisone (Prednisone) was purchased from Shanghai Macklin Biochemical Technology Co., Ltd., batch number: C11008416, and the molecular formula is C 21 h 26 o 5 , the molecular weight is 358.43. For the experimental grouping, see Example 1. The halcinonide group was replaced by the prednisone group. The administration method was gavage, and the dose was 20 mg / kg / d. Model preparation and detection indicators are the same as in Example 1.

[0104] 2. Experimental results

[0105] (1) Assessment of neurological deficit score

[0106] SD rats were administered for 1 day, and after 2 hours of ischemia in the MCAO model, they were treated with drugs again, and after 24 hours of reperfusion, the neurofunctional and behavioral scores of rats in each group were shown in the appendix. Figure 4 . like Figure 4 A...

Embodiment 3

[0109] Example 3. Study on the Effect of Testosterone Propionate in Treating Ischemic Stroke

[0110] 1. Refer to Embodiment 1 for the specific implementation method.

[0111] Testosterone Propionate (Testosterone Propionate) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd., batch number: A1910098, and the molecular formula is C 22 h 32 o 3 , the molecular weight is 344.49. For the experimental grouping, see Example 1. The halcinonide group was replaced by the testosterone propionate group. The administration method was gavage, and the dose was 20 mg / kg / d. Model preparation and detection indicators are the same as in Example 1.

[0112] 2. Experimental results

[0113] (1) Assessment of neurological deficit score

[0114] SD rats were administered for 1 day, and after 2 hours of ischemia in the MCAO model, they were treated with drugs again, and after 24 hours of reperfusion, the neurofunctional and behavioral scores of rats in each group were shown i...

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Abstract

The invention relates to the technical field of medicine, in particular to the application of halcinonide and its derivatives in the preparation of medicines for treating and / or preventing cerebrovascular diseases. The halcinonide and its derivatives described in the present invention have the general structural formula shown in formula (I), and their therapeutic effect on ischemic stroke is evaluated by MCAO cerebral ischemia-reperfusion injury animal model. The experimental results show that halcinonide and its derivatives prednisone and testosterone propionate can significantly improve the animal neurological deficit score, reduce the size of the infarct, can be used to treat ischemic stroke, and has a good clinical effect. Application prospects.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of halcinonide and derivatives thereof in the preparation of medicines for treating and / or preventing cerebrovascular diseases. Background technique [0002] Stroke (Stroke) is a common clinical disease with high morbidity. It has the characteristics of high morbidity, high mortality and high disability rate. It is the first cause of death in my country and the second leading cause of death in the world. It seriously affects the quality of life of patients, and hemiplegia often occurs after treatment, which brings huge economic and social burdens. With the increase of the aging population in my country, the incidence of stroke is gradually increasing. Stroke is divided into ischemic stroke and hemorrhagic stroke, of which ischemic stroke accounts for 60% to 70% of the total stroke. A general term for brain tissue necrosis caused by stenosis or occlusion, insuff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61K31/573A61K31/567A61K31/565A61K31/566A61P9/10
CPCA61K31/58A61K31/573A61K31/567A61K31/565A61K31/566A61P9/10
Inventor 陈新平赵文阳刘菁菁李响响
Owner 上海普佑生物医药有限公司
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