Construction method and device of depression-induced breast cancer animal model and application

An animal model and construction method technology, applied in the biological field, can solve the problems of high animal mortality, large individual differences, and long modeling time, and achieve the effects of low animal mortality, small individual differences, and short modeling time.
CN113100176AActive Publication Date: 2021-07-13GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Publication Date
2021-07-13

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Abstract

The invention discloses a construction method and device for a depression-induced breast cancer animal model and application. The construction method comprises the following steps that a mouse is placed in a constraining device not to act, the mouse is constrained for 4 hours every day, light-dark circulation is maintained for 12 hours for 3 weeks or more, and constructing is carried out to obtain the spontaneous breast cancer transgenic mouse depressive disorder animal model with depressive disorder related phenotypes. The invention further discloses a constraint device of the animal model. The animal model is used for simulating the human breast cancer and depression process and screening diagnosis and treatment drugs or therapies. The animal model has the advantages of good repeatability, small individual difference, short modeling time, low animal death rate and the like, and can be widely applied to simulation of human depression-induced breast cancer and related disease pathology and screening and curative effect verification of diagnosis and treatment substances.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a method, device and application for constructing an animal model of breast cancer induced by depression. Background technique

[0002] Depression (also known as depressive disorder) is a widespread chronic medical condition that can affect thought, mood, and physical health. It is characterized by persistently depressed mood, restlessness, and impaired motivation, and can range from psychomotor disturbances to cognitive impairments. Depression is also associated with serious physical health comorbidities, including cardiovascular disease, metabolic risk factors such as obesity, and premature death, with huge economic costs to society. Treatment and prevention of depression remain a public health priority.

[0003] Breast cancer is the most common malignant tumor in women and one of the three most common cancers in the world. The probability of women suffering from breast cancer in...

Claims

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