In-vitro liver perfusion activity maintaining device and using method thereof

Abstract

The invention discloses an in-vitro liver perfusion activity maintaining device and a using method thereof. The in-vitro liver perfusion activity maintaining device comprises a box chamber, a liver inlet pipeline, a liver outlet pipeline and a bile duct pipeline. The box chamber comprises an outer-layer temperature control box and an inner-layer storage box arranged in the outer-layer temperature control box, the outer-layer temperature control box is used for controlling the inner-layer storage box to keep constant temperature, and the inner-layer storage box is used for storing an in-vitro liver; the liver inlet pipeline is used for being connected with the artery and / or portal vein of the in-vitro liver, the liver outlet pipeline is used for being connected with the inferior vena cava of the in-vitro liver, and the bile duct pipeline is used for being connected with the bile duct of the in-vitro liver.

Description

technical field [0001] The invention relates to an isolated liver perfusion activity maintenance device and an application method thereof, belonging to the technical field of liver transplantation. Background technique [0002] Liver transplantation has become one of the most effective options for the treatment of end-stage liver disease and acute fulminant hepatic failure. However, the shortage of liver donors is the main problem facing all countries in the world at this stage. my country adopts the donation of citizens’ organs after death to obtain donated livers; however, most of the livers donated after the death of citizens are marginal donor livers, such as: fatty liver donors, elderly donors Wait. With the development of technology, the bioartificial liver has gradually become an important means of life support for acute fulminant liver failure, helping patients recover their own liver function, or waiting for liver transplantation plans. [0003] At present, there a...

Images