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Application of deferiprone in inhibition of ototoxicity of aminoglycoside drugs

An aminoglycoside, deferiprone technology, applied in the field of drug-induced deafness, can solve the problem that the problem cannot be solved fundamentally, and the effect depends on the quantity and quality of hair cells.

Pending Publication Date: 2021-08-10
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, although hearing aids and cochlear implants commonly used in clinical practice can improve the hearing of patients to a certain extent, they have certain limitations and cannot fundamentally solve the problem, and their effects are completely dependent on the quantity and quality of hair cells. The cause and mechanism of hair cell damage are crucial to the prevention and treatment of sensorineural hearing loss

Method used

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  • Application of deferiprone in inhibition of ototoxicity of aminoglycoside drugs
  • Application of deferiprone in inhibition of ototoxicity of aminoglycoside drugs
  • Application of deferiprone in inhibition of ototoxicity of aminoglycoside drugs

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Embodiment Construction

[0032] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0033] In some examples of the present invention, DFP (Deferiprone) refers to deferiprone, and the DFP used is directly purchased from MCE company, and the structural formula can be:

[0034]

[0035] In some examples of the present invention, the aminoglycoside drugs may be aminoglycoside antibiotics (Aminoglycosides), which are glycoside antibiotics formed by linking aminosugar and aminocyclic alcohol through oxygen bridges.

[0036] First, a PINK1 / Parkin-medi...

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Abstract

The invention discloses application of deferiprone in inhibition of ototoxicity of aminoglycoside drugs, and belongs to the field of drug-induced deafness. The invention discloses an application of deferiprone (DFP) in protection of hearing loss caused by aminoglycoside drugs. The DFP is the only oral active iron chelating agent and is clinically used for treating blood transfusion iron overload in thalassemia. According to the application, aminoglycoside drug damage, hair-like cells HEI-OC1 and mitochondrial autophagy occurrence levels in in-vitro cultured cochlea tissues are firstly researched, the protective effect of the DFP on the hair cells by regulating mitochondrial autophagy on the in-vitro cultured cochlea tissues is researched, and finally, the protective effect of the DFP on mouse hearing loss caused by aminoglycoside drugs is researched. A new thought is provided for treating drug-induced deafness, and a new target is provided for clinically helping a patient to recover and reconstruct an auditory function.

Description

technical field [0001] The invention relates to the field of drug-induced deafness, in particular to the application of deferiprone in inhibiting the ototoxicity of aminoglycoside drugs. Background technique [0002] Hearing impairment is the most prevalent ear disease in the world. The report of the World Health Organization shows that in 2005, 278 million people worldwide suffered from hearing loss, accounting for 4.6% of the world's population, and 80% of them lived in low- and middle-income countries. The number of deaf patients ranks second in the number of disabled people in my country. With the aging population, ototoxic drug abuse, noise and environmental pollution, the number of deaf and hearing impaired people is increasing year by year. Deafness has become a global issue that affects social politics and economy. Sexual health problems, among which sensorineural deafness accounts for about 63% of deaf patients, and cochlear hair cell damage is one of the main cause...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/4412A61K31/7036A61K31/702A61K31/7048A61P27/16A01K67/02
CPCA61K45/06A61K31/4412A61K31/7036A61K31/702A61K31/7048A61P27/16A01K67/02A01K2227/105A01K2267/03A61K2300/00
Inventor 柴人杰方巧军张玉花高下程诚项尚
Owner SOUTHEAST UNIV
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