The invention provides a composition comprising an effective dose of etimicin or a pharmaceutically acceptable salt thereof, an anti-inflammatorily effective dose of steroids or non-steroid anti-inflammatory drugs, and an effective dose of a water-retaining or wetting agent or anti-xerophthalmia drug, and application of the composition to preparation of external drugs for local administration of the eyes, the nose or skin and for prevention and treatment of conjunctivitis in human beings or mammals, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, cataract, otitis externa, otitis media, folliculitis, furuncle, pustule and the like. The composition provided by the invention has better curative effect or treatment compliance.