Compound quinolone injection for livestock, and preparation method thereof

A technology of quinolones and injections, which is applied in the field of livestock and poultry drugs, can solve the problems of unfavorable stress disease recovery, drug-resistant drug residues, time-consuming and labor-intensive problems, and achieve the effects of improving immunity, reducing the number of administrations, and simple processes

Inactive Publication Date: 2013-01-02
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, quinolones, aminoglycosides, vitamin C, etc. are often used alone in clinical practice. In order to achieve the therapeutic effect, it is necessary to increase the dose or prolong the use time, so that drug resistance and drug residues are likely to occur. The medicine is time-consuming and labor-intensive, and the intensity of injection administration will cause stress and hinder the recovery of the disease.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A kind of compound quinolone injection for livestock and poultry, it comprises active ingredient and solvent, and wherein active ingredient is made up of following components, and the mass volume concentration of each component is:

[0057] Ofloxacin 5%;

[0058] Gentamic Sulfate - Micronomycin 5%;

[0059] Vitamin C 2%;

[0060]Taurine 5%;

[0061] Polyvinylpyrrolidone 5%;

[0062] Sodium bisulfite 0.1%;

[0063] EDTA-2Na 0.01%;

[0064] The solvent is water for injection.

[0065] The compound quinolone injection for livestock and poultry is prepared by the following method:

[0066] 1) Add water for injection to ofloxacin, and adjust the pH to 2.8 by adding hydrochloric acid solution with a mass volume concentration of 12% to dissolve it to obtain solution I;

[0067] 2) Add water for injection to gentamicin sulfate-micronomycin, and adjust the pH to 4.8 by adding hydrochloric acid solution with a mass volume concentration of 12% to dissolve it to obtain solut...

Embodiment 2

[0072] A compound quinolone injection for livestock and poultry, which includes an active ingredient and a solvent, wherein the active ingredient is composed of the following components, and the mass volume concentration of each component is:

[0073] Ofloxacin 1%;

[0074] Gentamic Sulfate-Micronomycin 20%;

[0075] Vitamin C 5%;

[0076] Taurine 1%;

[0077] Polyvinylpyrrolidone 2%;

[0078] Sodium bisulfite 0.1%;

[0079] EDTA-2Na 0.01%;

[0080] The solvent is water for injection.

[0081] The compound quinolone injection for livestock and poultry is prepared by the following method:

[0082] 1) Add water for injection to ofloxacin, and adjust the pH to 2.5 by adding hydrochloric acid solution with a mass volume concentration of 20% to dissolve it to obtain solution I;

[0083] 2) Add water for injection to genta-micronomycin sulfate, and adjust the pH to 5.5 by adding hydrochloric acid solution with a mass volume concentration of 20% to dissolve it to obtain soluti...

Embodiment 3

[0088] A compound quinolone injection for livestock and poultry, which includes an active ingredient and a solvent, wherein the active ingredient is composed of the following components, and the mass volume concentration of each component is:

[0089] Ofloxacin 30%;

[0090] Gentamic Sulfate-Micronomycin 2%;

[0091] Vitamin C 0.2%;

[0092] Taurine 8%;

[0093] Polyvinylpyrrolidone 10%;

[0094] Sodium bisulfite 0.1%;

[0095] EDTA-2Na 0.01%;

[0096] The solvent is water for injection.

[0097] The compound quinolone injection for livestock and poultry is prepared by the following method:

[0098] 1) Add water for injection to ofloxacin, and adjust the pH to 3.5 by adding hydrochloric acid solution with a mass volume concentration of 6% to dissolve it to obtain solution I;

[0099] 2) Add water for injection to genta-micronomycin sulfate, and adjust the pH to 4.5 by adding hydrochloric acid solution with a mass volume concentration of 6% to dissolve it to obtain solut...

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Abstract

The present invention specifically discloses a compound quinolone injection for livestock, and a preparation method thereof. The compound quinolone injection for livestock comprises an active component and a solvent, wherein the active component comprises the following components, by mass volume concentration, 1-30% of a quinolone drug, 2-20% of an aminoglycoside drug, 0.2-5% of vitamin C, 1-8% of taurine, 2-10% of a co-solvent, 0.1% of an antioxidant, and 0.01% of EDTA-2Na, and the solvent is water for injection. The preparation method comprises: dissolving the components, adopting a hydrochloric acid solution to adjust the pH value to 3.5-5.5, filtering with a filter membrane, carrying out sub-package, and carrying out flowing steam sterilization. According to the injection of the present invention, gram-positive bacteria infections and gram-negative bacteria infections or mixing infections of bacterial and mycoplasma in the livestock can be treated, the injection is easy to use in clinic, and rapid animal disease rehabilitation is easily achieved.

Description

[0001] technical field [0002] The invention relates to the field of livestock and poultry medicines, in particular to a compound quinolone injection for livestock and poultry and a preparation method thereof. [0003] Background technique [0004] Quinolones are synthetic antibacterial drugs with a basic structure of 4-quinolone ring. Since the 1980s, this class of drugs has developed rapidly and has become the most commonly used class of antibacterial drugs in veterinary clinics, playing an important role in the prevention and treatment of infectious diseases. The quinolones commonly used in veterinary clinics in my country include enrofloxacin, sarafloxacin, difloxacin, dafloxacin, ofloxacin, norfloxacin, ciprofloxacin, pefloxacin, Lomefloxacin and others. This type of drug can be widely used in small animals, poultry, and livestock to treat digestive, respiratory, urinary, reproductive and other systems and skin and soft tissue infectious diseases caused by bacteria a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/7036A61P31/04A61K31/375A61K31/4709A61K31/496A61K31/5383
Inventor 刘小艳方炳虎陈瑞爱袁照红湛穗璋汤钦
Owner GUANGDONG WENS DAHUANONG BIOTECH
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