A kind of amoxicillin colistin sulfate granule and preparation method thereof

A technology of amoxicillin sulfate and amoxicillin, applied in the field of amoxicillin colistin sulfate granules and preparation thereof, can solve the problems of increasing the dosage, prolonging the medication time, high labor intensity, etc. Effects of stress response, dose reduction, and frequency reduction

Inactive Publication Date: 2015-09-02
GUANGDONG WENS DAHUANONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because colistin sulfate is directly mixed with amoxicillin, it is easy to absorb moisture and cause its agglomeration and discoloration, which is not conducive to storage and is easy to lose efficacy
[0003] With the rapid development of my country's animal husbandry, various diseases are becoming more and more complicated, and most cases are mixed infections, including both Gram-positive bacteria and Gram-negative bacteria, which brings difficulties to clinical disease treatment. In order to achieve the clinical therapeutic effect, various unilateral preparations are used alone in large quantities, which not only brings stress to the animals but also brings great labor intensity
Clinically, in order to achieve the therapeutic effect, unilateral medication generally increases the dosage or prolongs the medication time, so that drug resistance and drug residues are prone to occur, and unilateral administration is time-consuming and laborious; if injection administration is used, not only the labor intensity is greater but also the stress the animal
At present, a compound injection containing amoxicillin and colistin sulfate has appeared. This injection contains prednisolone, but prednisolone has great side effects and is unsafe for animal food, and the injection The liquid is administered by injection, which is labor-intensive and easily causes stress to animals

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A kind of amoxicillin sulfate colistin granule, it comprises active ingredient and auxiliary material, and wherein active ingredient is made up of following components, and the weight portion concentration of each component is:

[0039] Amoxicillin 10 parts;

[0040] 1 part colistin sulfate;

[0041] Polyethylene glycol-6000 15 parts

[0042] Lactose 74 parts

[0043] Wherein the binder is 2.5 parts of the total weight of the above components and a mass concentration of 5% povidone K30 ethanol solution.

[0044] The amoxicillin sulfate colistin granule is prepared by the following method:

[0045] 1) Sieve the amoxicillin, colistin sulfate, polyethylene glycol-6000, and lactose in the prescription with a sieve of 80 mesh or above for use;

[0046] 2) Weigh an appropriate amount of povidone K30 to completely dissolve it in 50% ethanol solution to obtain a 5% ethanol solution of povidone K30, which is used as an adhesive solution for later use;

[0047] 3) Fully mix ...

Embodiment 2

[0050] A kind of amoxicillin colistin sulfate granule, it comprises the following components by weight:

[0051] Amoxicillin 5 parts;

[0052] 10 parts of colistin sulfate;

[0053] Povidone K30 10 parts

[0054] Lactose 75 parts

[0055] Wherein the binder is an ethanol solution of polyethylene glycol-6000, which accounts for 2 parts of the total weight of the above-mentioned components and has a mass concentration of 5%.

[0056] The amoxicillin sulfate colistin granule is prepared by the following method:

[0057] 1) Sieve the amoxicillin, colistin sulfate, povidone K30, and lactose in the prescription with a sieve above 80 mesh for use;

[0058] 2) Weigh an appropriate amount of polyethylene glycol-6000 and dissolve it completely in 50% ethanol solution to obtain 5 parts of polyethylene glycol-6000 ethanol solution, which will be used as the adhesive solution for later use;

[0059] 3) Fully mix the weighed amoxicillin and povidone K30 first to obtain mixture A, then ...

Embodiment 3

[0062] A kind of amoxicillin colistin sulfate granule, it comprises the following components by weight:

[0063] Amoxicillin 2 parts;

[0064] 15 parts of colistin sulfate;

[0065] Poloxamer 188 5 parts

[0066] Glucose 78 parts

[0067] Wherein the binder accounts for 5 parts of the total weight of the above components and has a mass concentration of 6% poloxamer 188.

[0068] The amoxicillin sulfate colistin granule is prepared by the following method:

[0069] 1) Sieve the amoxicillin, colistin sulfate, poloxamer 188, and glucose in the prescription with a sieve above 80 mesh for use;

[0070] 2) Weigh poloxamer 188 to completely dissolve it in water to obtain a 6% poloxamer 188 solution, which is used as a binder solution for later use;

[0071] 3) Fully mix the weighed amoxicillin and poloxamer 188 first to obtain mixture A, then fully mix colistin sulfate and glucose to obtain mixture B, mix mixture A and B and add the prepared Appropriate amount of good adhesive so...

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PUM

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Abstract

The invention discloses an amoxicillin colistin sulphate granule and a preparation method thereof. The amoxicillin colistin sulphate granule comprises the following ingredients in parts by weight: 1-25 parts of amoxicillin, 0.5-50 parts of colistin sulphate and 50-90 parts of additives, as well as an adhesive accounting for 0.5-8 parts of the weight sum of the ingredients, and the amoxicillin colistin sulphate granule is prepared by such steps as sieving, dissolving, mixing, drying and pelletizing. The amoxicillin and colistin sulphate in the invention can be uniformly mixed, thereby improving the solubility of the product in water, reinforcing the efficacy, ensuring the treatment effect, facilitating the quick recovery of animals, guaranteeing easy storage and low by-effect and reinforcing the treatment effect by drug combination; the amoxicillin colistin sulphate granule can be not only used for treating mixed infection of pigs, but also being conveniently applied on clinic and facilitating the prevention and treatment of group animal diseases so as to alleviate animal stress reactions and reduce the labor intensity of manual drug use.

Description

technical field [0001] The invention relates to the field of veterinary drug preparations, in particular to amoxicillin colistin sulfate granules and a preparation method thereof. Background technique [0002] Amoxicillin, also known as amoxicillin, is a semi-synthetic acid-resistant broad-spectrum penicillin antibiotic. The drug has a wide antibacterial spectrum, strong bactericidal power, and rapid action. It is effective against major Gram-positive bacteria and some negative bacteria such as Streptococcus, Pasteurella, staphylococcus that does not produce penicillinase, Escherichia coli, Salmonella, Proteus mirabilis, etc. All are sensitive, and can be widely used in the treatment of sensitive bacterial infections of the urinary tract, respiratory tract and skin of various animals. At present, it has been used for the infection of sensitive bacteria in pigs, cattle and poultry. However, amoxicillin has low solubility in water and is easy to absorb moisture. It is not on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/12A61K9/16A61P31/04A61K31/43
Inventor 刘小艳方炳虎陈瑞爱
Owner GUANGDONG WENS DAHUANONG BIOTECH
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