Compound aminoglycoside drug composition for local administration

Abstract

The invention provides a composition comprising an effective dose of etimicin or a pharmaceutically acceptable salt thereof, an anti-inflammatorily effective dose of steroids or non-steroid anti-inflammatory drugs, and an effective dose of a water-retaining or wetting agent or anti-xerophthalmia drug, and application of the composition to preparation of external drugs for local administration of the eyes, the nose or skin and for prevention and treatment of conjunctivitis in human beings or mammals, angular blepharitis, keratitis, scleritis, trachoma, xerophthalmia, cataract, otitis externa, otitis media, folliculitis, furuncle, pustule and the like. The composition provided by the invention has better curative effect or treatment compliance.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to provide the prevention or treatment of conjunctivitis, canthal blepharitis, trachoma, keratitis, dry eye syndrome, otitis externa, otitis media, cataract, folliculitis, furunculosis, impetigo An effective dose of etimicin or its pharmaceutically acceptable salt and an effective dose of dexamethasone or its derivatives for topical ophthalmic or ear or nasal or skin external application Or oral pharmaceutical composition and use. Background technique [0002] Etimicin is an aminoglycoside drug developed in China, and it is currently listed as the fourth-generation semi-synthetic water-soluble aminoglycoside antibiotics internationally (document: Chaudhary M1, Kesava Naidu G, Kumar S, PayasiA. Comparative antibacterial activity of A novel semisynthetic antibiotic: etimicin sulphate and other aminoglycosides. World J Microbiol Biotechnol. 2012Dec; 28(12): 3365-71.), its mechanism o...

AI Technical Summary

Problems solved by technology

[0013] A drug may exhibit different effects and toxic reactions after being administered by different routes of administration or administration sites. One route of administration is effective, but another route of administration is ineffective or poorly effective, or different drugs are administered in different The toxicity in the route of administration is different, which is very common in pharmacy. At present, gatifloxacin and moxifloxacin, which are administered orally or intravenously, have been clearly used for the treatment of ophthalmic diseases [Document 1 , Chen Zuji, the application research progress of gatifloxacin in ophthalmology, Chinese Journal of Optometry & Ophthalmology, 2006, 8(6):400-402; Document 2, Chen Zuji; a broad-spectrum and highly effective new fluoroquinolone antibacterial drug Moxifloxacin and its application in ophthalmology, Ophthalmology Research, Chinese Ophthalmic Research, 2005, 06: 656-659;], however, cephalexin and cefadroxil can only be taken orally but cannot be injected or the effect is very poor, and ceftriaxone Sodium pine and cefminox sodium can only be administered by injection, but cannot be administered orally or are almost ineffective when administered orally. Topical administration such as sodium cromoglycate eye drops or sprays is effective in the treatment of conjunctivitis, allergies or asthma, and is a popular and commonly used drug in the world. , but the convenient oral tablets or capsules are worthless; typical but not widely known examples may also include: the toxicity of aminoglycoside spectinomycin hydrochloride is much higher than that of intramuscular injection, As a result, the drug cannot be given intravenously at therapeutic doses and can only be given intramuscularly

However, there is currently no public literature reporting the combined administration of etimicin and dexamethasone for the treatment of ophthalmic diseases or the clinical efficacy or toxicity of local administration, and its efficacy or adverse effects at different dosages are unknown. Reaction or toxicity or irritation to the retina or cornea, etc., the toxic effects of drugs on the eye are diverse and complex

The eye is the window of the human soul and one of the most important organs of animals. The cornea of ​​the eye is very sensitive to drugs. Once the exposure to chemical substances is uncomfortable or causes serious adverse reactions, the result of a slight difference in production is likely to cause serious adverse reactions Or blindness, etc. In recent years, there are still unexplained severe blinding adverse reactions of perfluoropropane gas for ophthalmic use in the case of passing the inspection, resulting in dozens of blindness

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