Combination therapy of phosphate binders and vitamin K

一种磷酸盐结合剂、维生素的技术，应用在药物组合、含有效成分的医用配制品、医药配方等方向，能够解决耗尽等问题

Pending Publication Date: 2021-08-13
NATTOPHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Thus, by binding to vitamin K, phosphate binders can further deplete what may already be low (ie, subclinical deficiency) levels of vitamin K in these subjects

Method used

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  • Combination therapy of phosphate binders and vitamin K

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Embodiment Construction

[0007] The present disclosure relates to a method of administering to a subject a combination of a phosphate binder and vitamin K, wherein the function of the combination is to reduce serum phosphate levels in the subject; protect the vasculature from calcification; reverse vascular Calcification; reduction of non-bone calcium levels; alleviation of bone degeneration; reduction of the dose of phosphate binders to achieve the same benefit, or to reduce their side effects; and / or reduction of cardiovascular events (MACE), morbidity or mortality. The subject can be a patient with CKD. In certain embodiments, the subject can be a patient with CKD and cardiovascular disease (CVD). In certain embodiments, the patient may be undergoing concomitant dialysis treatment. The method can be used to treat CVD in a patient with CKD, or to prevent the onset of CVD in a CKD patient.

[0008] Combinations according to the present disclosure include vitamin K. Those skilled in the art will un...

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Abstract

A method of treating chronic kidney disease includes administering to a subject in need thereof a combination of a vitamin K and a phosphate binder.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 788,523, filed January 4, 2019, the disclosure of which is incorporated herein by reference in its entirety. technical field [0003] The present disclosure relates to the use of combination therapy comprising a phosphate binder and vitamin K. The combination can be used, for example, to treat patients with chronic kidney disease; to reduce high serum phosphate levels (also known as hyperphosphatemia); to protect the vasculature from calcification; to reverse vascular calcification; To reduce non-bone calcium levels; to alleviate bone degeneration; to reduce the dose of phosphate binders to achieve the same benefit, or to reduce their side effects; and / or to reduce cardiovascular events (MACE), morbidity, or mortality . Background technique [0004] Patients with chronic kidney disease (CKD) are prone to several various complications. For...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P13/12A61P3/14A61K31/122A61K31/395
CPCA61K31/122A61K45/06A61P13/12A61K2300/00A61P9/00
Inventor 丹尼尔·H·罗森鲍姆李·M·泰克纳
Owner NATTOPHARMA
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