NGR modified shikonin nano-micelle as well as preparation method and application thereof

A technology of nano-micelle and shikonin, which is applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., can solve the problems of short retention time, low bioavailability, poor solubility, etc.

Pending Publication Date: 2021-09-07
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the clinical application of SHI is limited by the bioactive properties of poor solubility, short retention time, and low bioavailability

Method used

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  • NGR modified shikonin nano-micelle as well as preparation method and application thereof
  • NGR modified shikonin nano-micelle as well as preparation method and application thereof
  • NGR modified shikonin nano-micelle as well as preparation method and application thereof

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Embodiment Construction

[0042] Specific details of the invention are further set forth in the ensuing description for a full understanding of the invention. The terms used in the description of the present invention are only used to describe the advantages and features of the present invention, and are not intended to limit the present invention.

[0043] Unless otherwise defined, all professional and scientific terms used in the present invention have the same meaning as understood by those skilled in the technical field of the present invention. Unless otherwise specified, the medicines or reagents used in the present invention are used in accordance with product instructions or conventional methods in the field. The technical solution of the present invention will now be further described according to the accompanying drawings and specific embodiments of the specification.

[0044] It should be noted that, in the following examples, shikonin (SHI) (purity>99%) was purchased from Huzhou Zhanshu Bi...

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Abstract

The invention discloses an NGR modified shikonin nano-micelle as well as a preparation method and application thereof. The nano-micelle comprises NGR-PEG-PDLLA and shikonin, wherein the chemical structural formulas of the NGR-PEG-PDLLA and the shikonin are shown as a formula 1 and a formula 2 respectively. The NGR-SHI-PM provided by the invention can provide a platform for in-vitro and in-vivo targeted treatment of AR through an NF-kappa B way of targeted PARP, and can be used as a new strategy for treating AR.

Description

technical field [0001] The invention relates to the technical field of allergic rhinitis treatment, in particular to an NGR-modified shikonin nano-micelle and its preparation method and application. Background technique [0002] The information disclosed in the Background of the Invention is only intended to increase the understanding of the general background of the invention, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes the prior art that is already known to those skilled in the art. [0003] Allergic rhinitis (AR) is an inflammatory disease of nasal mucosa caused by IgE-mediated inflammatory response, characterized by nasal congestion, runny nose, sneezing and nasal itching. The impact of AR on patients' perceived health conditions is enormous. In addition, AR has been shown to be an important risk factor for many diseases. It is now clear that allergic inflammation in AR is associated with Th 2 rela...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K47/42A61K47/34A61K47/64A61K47/60A61K31/122A61P11/02A61P37/08
CPCA61K9/1075A61K47/42A61K47/34A61K47/64A61K47/60A61K31/122A61P11/02A61P37/08
Inventor夏明刘成程赵苗青齐雯雯杜宏杰郑雪
OwnerSHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY