New application of baricitinib in treatment of psychological abnormality and obesity
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An obesity and new-purpose technology, applied in the field of baricitinib, can solve problems such as mental abnormalities and obesity without baricitinib
Inactive Publication Date: 2021-09-17
杨孟君
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In the existing patents, there is no use of baricitinib in the treatment of mental disorders and obesity
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[0019] The present invention is further described through two embodiments below, but the present invention is not limited to these embodiments.
[0020] One embodiment of the present invention is made from the following raw materials in parts by weight: 0.5-5 parts of baricitinib, 35-40 parts of polyether polyol A, 50-70 parts of polyether polyol B, and 2-4 parts of water , 0.15-0.3 parts of octoate, 0.15-0.3 parts of dichloromethane, 0.5-2.5 parts of foam stabilizer, 1-2 parts of sponge color paste; wherein the polyether polyol is a 4-functional polyol with a molecular weight of 4000 Oxypropylene-oxyethylene ether polyol, produced by Zibo Dexin Federal Chemical Industry Co., Ltd.; the polyether polyol B is polyoxyethylene ether polyol with 4 functionalities and a molecular weight of 4300, produced by Zibo Dexin Federal Chemical Industry Co., Ltd. Produced by the company, the model of the foam stabilizer is L-580, produced by Momentive Company of the United States; the raw mat...
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Abstract
The invention relates to a novel application of baricitinib in treatment of psychological abnormality and obesity, in particular to application of baricitinib in preparation of a medicine used for treating psychological abnormality diseases and the obesity. The medicine comprises the baricitinib, at least one medicine carrier and at least one non-medicine carrier. The medicine comprises external auditory canal suspension medicine application, and the external auditory canal suspension medicine application is characterized in that the medicine disclosed by the invention is implanted into microporous slow-rebound sponge earplugs, then, the earplugs are plugged into external auditory canals of double ears, and the medicine is applied through ear canal wall ear hair cells and auditory tubes by medicine information induction or odor wave transmission, toxic and side effects of the medicine can be reduced, and safety is improved.
Description
technical field [0001] The present invention relates to a new application of baricitinib, in particular to the application of baricitinib in the treatment of abnormal mental diseases and obesity. Background technique [0002] Baricitinib is a JAK inhibitor. JAK inhibitors can selectively inhibit JAK kinases and block the JAK / STAT pathway. After searching the relevant patents of baricitinib, it can be seen that the application number is CN200980116857.7, which discloses various indications of baricitinib, including the treatment of autoimmune diseases, such as skin diseases, multiple sclerosis , rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, type 1 diabetes, lupus, inflammatory bowel disease, Crouse's disease, myasthenia gravis, immunoglobulin nephropathy, myocarditis, or autoimmune thyroid disease; autoimmune skin disease, and is atopic dermatitis, psoriasis, skin sensitization, skin irritation, rash, contact dermatitis or allergic contact sensitization; ca...
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Application Information
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