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A kind of synthetic method and application of 2-undecyloxyl-1-ethanol

A synthesis method and alkoxy technology, which are applied in the directions of application, botanical equipment and method, ester reaction to prepare ether, etc., can solve the problems of inability to large-scale production, long reaction steps, low reaction yield, etc., and achieve low product cost. , the reaction conditions are mild and controllable, and the reaction yield is high.

Active Publication Date: 2022-06-28
PHEROBIO TECHNOLOGY CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, although the synthesis research of 2-undecyloxy-1-ethanol has made great progress, there are still many problems, such as low reaction yield, expensive raw materials, long reaction steps, and shortcomings such as large-scale production.

Method used

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  • A kind of synthetic method and application of 2-undecyloxyl-1-ethanol
  • A kind of synthetic method and application of 2-undecyloxyl-1-ethanol
  • A kind of synthetic method and application of 2-undecyloxyl-1-ethanol

Examples

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Effect test

Embodiment 1

[0032] A kind of synthetic method of 2-undecyloxy-1-ethanol, specifically comprises the following steps:

[0033] Add 136.4g of ethylene glycol to a 250ml three-necked flask, add 12.6g of potassium hydroxide, then add homogeneous catalyst 18 crown-6 and heat it up to 85 degrees Celsius to react for 3h; then drop in 42.8g of 1-bromoundecane, heat up The reaction was carried out at 110° C. for 8 hours; after liquid separation, extraction was performed, the organic phases were combined, concentrated, and 32.4 g of a product with a purity of 99% was obtained by high-vacuum rectification.

Embodiment 2

[0034] Example 2: Pilot scale-up preparation

[0035] A kind of synthetic method of 2-undecyloxy-1-ethanol, specifically comprises the following steps:

[0036] (1) to 30L reactor, add 1# 16.38kg ethylene glycol, 1.5kg potassium hydroxide 2#, 290g homogeneous catalyst 18 crown-63# successively, heat up and stir to 85 ℃ of reaction 32h;

[0037] (2) 4# was added dropwise to the reaction kettle, the temperature was increased to 110°C after the dropwise addition, the reaction was stirred under reflux, and the reaction was sampled every 2h for 5h; the progress of the reaction was detected;

[0038] (3) stop the reaction when the reaction raw material is below 10% and the reaction by-product diether is below 9%;

[0039] (4) in the reaction solution, add 5L water to stir and inactivate, and separate liquids; wherein the water phase is extracted with 5L*3PE, and all organic phases are combined, add 3.0kg anhydrous sodium sulfate and dry, and concentrate to dryness under reduced pre...

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Abstract

The invention discloses a synthesis method of 2-undecyloxy-1-ethanol, which belongs to the technical field of chemical production. The present invention uses 1-bromoundecane and ethylene glycol as initial raw materials, adds a common strong base, and adopts a one-pot method to react after heating up to finally synthesize the 2-undecyloxy-1-ethanol. In the synthesis method disclosed by the invention, the reaction conditions are mild and controllable. It is mainly based on cheap raw materials, the product cost is low, the reaction yield is high, and the product content can reach more than 99% (GC detection), which is suitable for industrial scale production. In addition, the 2-undecyloxyl-1-ethanol synthesized by the method can be used as the sex pheromone component of Monochamus alternata, and it can be formulated into a lure combined with a trap, which can effectively trap and kill Monochamus alternata males. Therefore, the technical solution disclosed in the present invention has great market application and promotion prospects.

Description

technical field [0001] The invention belongs to the technical fields of chemical production and green pesticide synthesis, and relates to a method for synthesizing a novel pine brown beetle sex pheromone component. Specifically, it relates to a method for synthesizing 2-undecyloxy-1-ethanol and its application in the sex pheromone components of A. rosacea. Background technique [0002] Pine longhorn beetle is an important stem-boring pest of Chinese pine, and it is also the main vector insect of pine wood nematode, a devastating disease of pine. As an important forest quarantine pest, its larvae damage the phloem and xylem of the debilitating pine conducting tissue, destroy the transport of water and nutrients, and cause the wood to die. In the process of feeding and supplementing nutrients, the adult insects invade the pine tree by gnawing on the twigs, carrying the pine wood nematode in their body, infecting the pine tree and causing the pine tree to grow weak and eventua...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C41/16C07C43/13A01N31/02A01P19/00
CPCC07C41/16A01N31/02C07C43/13
Inventor 吕卫鹏崔艮中徐文泉陈海勋吴朋
Owner PHEROBIO TECHNOLOGY CO LTD
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