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Method for real time encoding of scanning swath data and probabilistic framework for precursor inference

A coding and data technology, applied in the field of coding and storage scanning SWATH mass spectrometry data, can solve the problem of reducing the file size of storage scanning SWATH data and so on

Pending Publication Date: 2021-11-09
DH TECH DEVMENT PTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the '459 application and the '753 patent do not address reducing the file size required to store scanned SWATH data without losing any information required for post-processing of the data

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  • Method for real time encoding of scanning swath data and probabilistic framework for precursor inference
  • Method for real time encoding of scanning swath data and probabilistic framework for precursor inference
  • Method for real time encoding of scanning swath data and probabilistic framework for precursor inference

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Embodiment Construction

[0048] computer implemented system

[0049] figure 1 is a block diagram illustrating a computer system 100 upon which embodiments of the present teachings may be implemented. Computer system 100 includes a bus 102 or other communication mechanism for communicating information, and a processor 104 coupled with bus 102 for processing information. Computer system 100 also includes memory 106 , which may be a random access memory (RAM) or other dynamic storage device, coupled to bus 102 for storing instructions to be executed by processor 104 . Memory 106 may also be used to store temporary variables or other intermediate information during execution of instructions to be executed by processor 104 . Computer system 100 also includes a read only memory (ROM) 108 or other static storage device coupled to bus 102 for storing static information and instructions for processor 104 . A storage device 110, such as a magnetic or optical disk, is provided and coupled to bus 102 for sto...

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Abstract

A precursor ion transmission window is moved in overlapping steps across a precursor ion mass range. The precursor ions transmitted at each overlapping step by the mass filter are fragmented or transmitted. Intensities or counts are detected for each of the one or more resulting product ions or precursor ions for each overlapping window that form mass spectrum data for each overlapping window. Each unique product ion detected is encoded in real-time during data acquisition. This encoding includes sums of counts or intensities of each unique ion detected the overlapping windows and positions of the windows associated with each sum. The encoding for each unique ion is stored in a memory device rather than the mass spectral data. A deblurring algorithm or numerical method is used to determine a precursor ion of each unique ion from the encoded data.

Description

[0001] related application [0002] This application claims the benefit of U.S. Provisional Patent Application Serial No. 62 / 855,242, filed May 31, 2019, the contents of which are incorporated herein by reference in their entirety. technical field [0003] The teachings herein relate to encoding and storing scanned SWATH mass spectrometry data. More specifically, the teachings herein relate to systems and methods for reducing the file size required to store scanned SWATH data by applying real-time encoding of scanned quadrupole dimensions based on quadrupole response functions or precursor ion inferred probability functions. Background technique [0004] As described below, scanning SWATH is a tandem mass spectrometry method in which a precursor ion mass selective window or a precursor ion transmission window is scanned across a mass range such that consecutive windows have large areas of overlap and small areas of non-overlapping. This scan makes the resulting product ions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72G01N30/86
CPCG01N30/02G01N30/72G01N30/8696H01J49/0045H01J49/0036G06F17/16G06F17/17
Inventor N·G·布洛姆菲尔德G·伊沃什夫
Owner DH TECH DEVMENT PTE
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