Clostridium difficile specific antigen peptide

Abstract

The invention relates to a clostridium difficile specific antigen peptide, in particular to a specific antigen peptide for a high-poison-yield clostridium difficile RT027. The clostridium difficile specific antigen peptide comprises an amino acid sequence as shown in SEQ ID No.1. A specific peptide fragment and a specific antibody thereof are used, a novel clostridium difficile high-poison-yield strain detection kit and a clostridium difficile vaccine can be developed, and the clostridium difficile specific antigen peptide has an important significance on detection and treatment of clostridium difficile high-poison-yield strain infection.

Description

technical field [0001] The invention relates to a Clostridium difficile specific antigen peptide. Background technique [0002] Clostridium difficile ( Clostridioides difficile , CD) is a Gram-positive obligate anaerobic spore-forming bacterium. CD is the main pathogenic bacterium of antibiotic-associated diarrhea (AAD) in hospitals, which can cause mild to severe diarrhea, colitis, pseudomembranous colitis, toxic megacolon, etc., and even death in severe cases. In recent years, the emergence of highly toxin-producing Clostridium difficile (RT027 / NAP1 / BI / ST01) has gradually increased the morbidity and mortality of Clostridiodes difficile infection (CDI), causing tens of thousands of deaths worldwide every year. The cost ran into the billions of dollars. [0003] In 2013, the US CDC (Center for Disease Control and Prevention) listed Clostridium difficile infection as the first urgent level of "microorganisms causing public health threats". Clostridium difficile is mainly ...

AI Technical Summary

Problems solved by technology

However, the current results of immunoassays on these surface-associated proteins show that these proteins still cannot effectively eliminate Clostridium difficile, and there is an urgen

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