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Amantadine binding protein

A technology of fusion proteins and sequences, applied in the field of amantadine-binding proteins

Pending Publication Date: 2021-12-14
UNIV OF WASHINGTON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the design of small molecule-induced trimers is a challenge for entirely new protein design with considerable practical relevance

Method used

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Examples

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Embodiment

[0060] We used novel protein design to create a homotrimeric protein conjugated to the small molecule drug amantadine. The X-ray structure closely matches the designed model, the neutron structure recapitulates the designed hydrogen-bonding network (data not shown), and solution NMR data show that amantadine binding induces local structural changes (data not shown). C 3 Small molecule binding at symmetric protein interfaces is an advance in computational protein design.

[0061] Despite the importance of trimers in pro-apoptotic and pro-inflammatory signaling cascades, no chemically induced trimer system has been developed. Thus, the design of small molecule-inducible trimers is a challenge for entirely new protein design with considerable practical relevance.

[0062] We set out to design trimeric proteins that bind small molecules with threefold symmetry on their axis of symmetry. We focus on C 3 The symmetrical compound amantadine because it is an FDA-approved drug with...

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Abstract

Disclosed herein are amantadine binding polypeptides, fusion proteins thereof, and uses of such polypeptides and fusion proteins.

Description

[0001] cross reference [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 834592, filed April 16, 2019, which is hereby incorporated by reference in its entirety. Background technique [0003] Despite the importance of trimers in pro-apoptotic and pro-inflammatory signaling cascades, no chemically induced trimer system has been developed. Thus, the design of small molecule-inducible trimers is a challenge for entirely new protein design with considerable practical relevance. [0004] References to Sequence Listings [0005] This application contains the Sequence Listing submitted as an electronic text file named "19-142-PCT_Sequence-Listing_ST25.txt", which is 5kb in size and was created on April 8, 2020. Pursuant to 37 CFR §1.52(e)(5), the information contained in this electronic file is hereby incorporated by reference in its entirety. Contents of the invention [0006] In one aspect, the disclosure provides at least 75%, 80%,...

Claims

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Application Information

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IPC IPC(8): C07K1/113C07K14/00
CPCC07K1/113C07K14/00A61K38/00C07K14/47C12N15/63
Inventor J·朴S·博伊肯K·魏G·奥伯多弗D·贝克尔
Owner UNIV OF WASHINGTON
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