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Ultrasonic contrast quantitative analysis method and system for dynamic follow-up tumor local radiotherapy and chemotherapy effects and computer readable storage medium

A technology of contrast-enhanced ultrasound and quantitative analysis, which is applied in the field of medical imaging, can solve the problems of poor accuracy and repeatability of quantitative analysis of contrast-enhanced ultrasound, and achieve the effect of strong repeatability and high accuracy

Pending Publication Date: 2022-03-18
ZHONGSHAN HOSPITAL FUDAN UNIV
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AI Technical Summary

Problems solved by technology

Although this prior art partially optimizes the quantitative analysis of contrast-enhanced ultrasound, its quantitative analysis results are mainly expressed through cluster analysis, which enhances the visualization effect of heterogeneity analysis, but it still cannot solve the problem of the accuracy and reliability of quantitative analysis of contrast-enhanced ultrasound. poor repeatability

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0049] Example 1 Evaluation of the Effect of Radiotherapy and Chemotherapy in Patients with Locally Advanced Pancreatic Cancer

[0050] A. Obtain dynamic contrast-enhanced ultrasound images of pancreatic cancer: perform contrast-enhanced ultrasonography imaging on patients with locally advanced pancreatic cancer, observe the lesion and collect continuous dynamic videos for at least 2 minutes from the time of contrast agent injection, and export the original DICOM compressed in JPEG format image.

[0051] B. Dynamic contrast-enhanced image preprocessing: In view of the difference in image resolution and overall image intensity caused by different sources of ultrasound equipment and contrast agent concentrations, the image pixel size is averaged down-sampled or A method for linear interpolation upsampling and normalization of pixel intensities. Reduced interpatient quantitative parameters were influenced by factors unrelated to actual lesion perfusion. For the noise in the ima...

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Abstract

The invention provides an ultrasonic contrast quantitative analysis method and system for dynamic follow-up tumor local radiotherapy and chemotherapy effects and a computer readable medium, and relates to the technical field of medical imaging. The ultrasonic contrast quantitative analysis method comprises the following steps: firstly, collecting continuous dynamic contrast images from the beginning of ultrasonic contrast agent injection, preprocessing the dynamic contrast images, then carrying out focus labeling based on breathing dynamic compensation, and finally carrying out fitting calculation to obtain a time-intensity curve TIC. Errors caused by factors such as equipment and human factors are eliminated through preprocessing, interference of respiratory movement of a patient on an image is counteracted on the basis of focus labeling of respiratory dynamic compensation, and finally a TIC curve is obtained through fitting calculation, so that the accuracy and repeatability of quantitative analysis are effectively improved; and a basis is provided for non-invasive sensitive tumor local radiotherapy and chemotherapy effect evaluation.

Description

technical field [0001] The present invention relates to the technical field of medical imaging, in particular to a method, system and computer-readable storage medium for quantitative analysis of contrast-enhanced ultrasound for dynamic follow-up of the effects of local radiotherapy and chemotherapy for tumors. Background technique [0002] Radiation therapy (hereinafter referred to as "radiotherapy") and chemotherapy (hereinafter referred to as "chemotherapy") are the main treatment methods for patients with advanced solid tumors, which can increase the local control rate of the tumor. During the treatment period, timely evaluation of the treatment effect and adjustment of the treatment plan are helpful. Helps prolong patient survival and improve quality of life. However, radiotherapy and chemotherapy are adjuvant or local palliative treatments, and its efficacy is difficult to accurately evaluate. At present, the most commonly used imaging method to evaluate the curative ...

Claims

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Application Information

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IPC IPC(8): G06T7/00G06T7/11G06T7/246G16H30/20G06T5/00A61B8/08A61B8/06
CPCG06T7/0012G06T7/11G06T7/246G16H30/20A61B8/06A61B8/481A61B8/5223A61B8/5276G06T2207/10072G06T2207/20104G06T2207/30204G06T2207/30096G06T5/70
Inventor 董怡郭曦吴莉莉王文平周宇红楼文晖
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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