Application of schisanhenol and derivatives thereof in preparation of medicine for treating depression and prepared antidepressant medicine

Abstract

The invention provides application of schisanhenol and a derivative thereof in preparation of a medicament for treating depression and the prepared antidepressant medicament. The application dosage is 0.01-30mg of schisanhenol or the derivative thereof per kilogram of body weight, and the anti-depression effect can be generated within 60 minutes after the schisanhenol or the derivative thereof is administrated. After the medicine is administrated for 5 days, the obvious anti-depression effect is generated in the low dosage and the high dosage. A research result shows that in a mammal mouse tail suspension experiment, schisanhenol or a derivative thereof has a rapid anti-depression effect, and is more effective than a conventional anti-depression drug imipramine. According to the invention, a forced swimming experiment and a mouse tail suspension experiment are adopted as drug screening experiments, and meanwhile, an open field test is carried out on the mouse, so that the autonomous activity of the mouse is detected, and the interference of central excitation drugs is avoided. The anti-depression drug has the advantages of being remarkable in anti-depression effect, quick in effect taking, small in dosage, small in side effect and the like, and is expected to become a new anti-depression drug which is quick, efficient and novel in mechanism.

Description

Technical field [0001] The invention belongs to the field of medical technology, and the use of Hernandezine and its derivatives in the preparation of the use of the treatment of depression drugs and the preparative antidepressants. Background technique [0002] Major Depression Disorder (MDD) is a serious, repeatedly sent disabled mental illness. There are approximately 3 billion depression in patients around the world. China's depression is 4.2%, and approximately 56 million depression patients. Depression is a major public health issue that is urgently needed to solve due to the second major cause of loss (year) due to loss (year) due to injury. The clinical depression can be seen that the mood is low, the mood is depressed, inferior depression, and even pessimistic, and there can be suicide attempts or behavior. At present, the antidepressant in the clinical bed mainly includes selective 5-hydroxycin re-intractive agent, 5-hydroxylamine and norepinephrine re-intramodal inhibi...

AI Technical Summary

Problems solved by technology

Schisandrin as an active ingredient in the prevention and treatment of depression has not been reported so far

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