Application of hyrandizine and derivative thereof in preparation of medicine for treating depression and prepared antidepressant medicine

Abstract

The invention provides application of hyrandizine and a derivative thereof in preparation of a medicament for treating depression and the prepared antidepressant medicament. According to the application dosage, 0.01-30 mg of Helendizime or the derivative thereof is applied to each kilogram of body weight, and the anti-depression effect can be achieved within 60 minutes after the Helendizime or the derivative thereof is administrated. After the medicine is administrated for 5 days, the obvious anti-depression effect is generated in the low dosage and the high dosage. A research result shows that in a mammal mouse tail suspension experiment, the hyrandizine or the derivative thereof has a rapid anti-depression effect, and is more effective than a conventional anti-depression drug imipramine. According to the method, a forced swimming experiment and a mouse tail suspension experiment are adopted as drug screening experiments, and meanwhile, an Open field test is carried out, so that the autonomous activity of a mouse is detected, and interference of central excitants is avoided. The anti-depression drug has the advantages of being remarkable in anti-depression effect, quick in effect taking, small in dosage, small in side effect and the like, and is expected to become a new anti-depression drug which is quick, efficient and novel in mechanism.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the application of Hernandezine and its derivatives in the preparation of medicines for treating depression and the prepared antidepressants. Background technique [0002] Major depressive disorder (MDD) is a severe, recurrent, disabling mental illness. There are approximately 300 million people with depression worldwide. The incidence rate of depression in China is 4.2%, and there are about 56 million depressed patients. Depression is the second leading cause of life lost (years) due to disability and has become a major public health problem that urgently needs to be addressed. Depression can be seen clinically with low mood, depressed mood, low self-esteem and depression, even pessimistic world-weariness, and there may be suicide attempts or behaviors. At present, the clinical first-line antidepressants mainly include selective serotonin reuptake inhibitors, serotonin and nor...

AI Technical Summary

Problems solved by technology

At present, there is no report on the prevention and treatment of depression with Hylandizine as an active ingredient

Images