Il20-rb-specific antibodies and uses thereof for treating acute aggregation of

A VL-CDR3, VL-CDR1 technology, applied in the field of immunology and medicine, can solve the problems of increased susceptibility to respiratory tract infection, changing lung barrier function, reducing immune defense mechanism, etc.

Pending Publication Date: 2022-04-12
INSERM法国国家健康医学研究院 +5
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chronic exposure to cigarette smoke (CS) triggers inflammatory processes that ultimately alter lung barrier

Method used

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  • Il20-rb-specific antibodies and uses thereof for treating acute aggregation of
  • Il20-rb-specific antibodies and uses thereof for treating acute aggregation of
  • Il20-rb-specific antibodies and uses thereof for treating acute aggregation of

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Experimental program
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Embodiment Construction

[0074] For our study, we developed an experimental model to mimic COPD disease in mice by chronic exposure to cigarette smoke (CS) (13). These mice have increased susceptibility to respiratory pathogens associated with defective IL-22 production (14, 15). In contrast, these animals showed increased expression of IL-19, IL-20, and IL-24 in response to S. pneumoniae or NTHi. Treatment with an anti-IL-20Rb blocking antibody increased bacterial clearance in control mice infected with Streptococcus pneumoniae (12) and protected CS-exposed mice from bacterial infection by reducing bacterial load and inflammatory infiltration (WO2016083304) . In view of these results, we hypothesized that IL-20 cytokine might contribute to the increased susceptibility of COPD mice to bacterial infection through its inhibitory effect on Th17 cytokine production.

[0075] To assess their role in COPD exacerbation, CS-exposed mice (clone 20RNTC, 50 μg / mouse, ip) were treated with blocking IL20RB antib...

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Abstract

Chronic obstructive pulmonary disease (COPD) is still the major cause of global morbidity and mortality. A COPD acute exacerbation patient (AE-COPD) is mainly caused by respiratory tract infection and is related to inevitable decline of lung function, edema exacerbation and airway and systemic inflammation. Previous results show that treatment with an anti-IL-20Rb blocking antibody increases bacterial clearance in control mice infected with Streptococcus pneumoniae and protects CS exposed mice from bacterial infection by reducing bacterial load and inflammatory infiltration. Therefore, people are of interest in the production of monoclonal antibodies specific for IL-20Rb with neutralizing activity for AE-COPD treatment. This need is met by providing an antibody that is specific for IL-20Rb.

Description

technical field [0001] The present invention relates to the field of medicine, especially the field of immunology. Background technique [0002] Chronic obstructive pulmonary disease (COPD) remains a leading cause of morbidity and mortality worldwide. According to the World Health Organization, it will be the third leading cause of death globally in 2030. COPD is a lung disease characterized by progressive and irreversible airflow limitation. Smoking is a major risk factor for the development of COPD. Chronic exposure to cigarette smoke (CS) triggers inflammatory processes that ultimately alter lung barrier function and reduce immune defense mechanisms, leading to increased susceptibility to respiratory infections. Such infections further alter the clinical status of COPD patients, indirectly contributing to widespread morbidity and mortality. Patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) are associated with an inevitable decline in ...

Claims

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Application Information

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IPC IPC(8): C07K16/28C12N15/13A61K39/395A61P11/00
CPCC07K16/2866C07K2317/76C07K2317/33C07K2317/92A61K2039/505A61P11/00C07K2317/24C07K2317/732A61K39/00C07K2317/21
Inventor P·戈塞特M·皮查万特P·马蒂诺M·陈图夫B·罗伯特M·勒鲁
Owner INSERM法国国家健康医学研究院
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