Application of ER and Ki-67 expression ratio in EC and AH retention fertility function treatment prognosis

A ki-67, prognostic technology, applied in the field of biomedicine, can solve the problem of high recurrence rate, not the best choice, especially, whether the recurrence is unknown, etc.

Pending Publication Date: 2022-05-06
PEOPLES HOSPITAL PEKING UNIV
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Problems solved by technology

The mainstay of treatment for AH and EC is surgery, however, many EC patients are diagnosed under the age of 44, so surgery is not the best option, especially for nulliparous women who wish to preserve the fertility of the uterus
It has been reported that the remission rate of EC patients receiving progestin-based conservative treatment is 50-80%, and the pre...

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  • Application of ER and Ki-67 expression ratio in EC and AH retention fertility function treatment prognosis
  • Application of ER and Ki-67 expression ratio in EC and AH retention fertility function treatment prognosis
  • Application of ER and Ki-67 expression ratio in EC and AH retention fertility function treatment prognosis

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Experimental program
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Embodiment

[0041] 1. Experimental method

[0042] 1. Medical records

[0043] From January 2010 to January 2021, 53 patients with EC and 68 patients with AH who required fertility preservation treatment in Peking University People's Hospital were collected.

[0044] The selected indications are: ①Aged ≤40 years old, patients aged 40-45 years are fully informed of the risk and fully informed consent can also be included; ②The pathological type is endometrial dysplasia, or well-differentiated (G1) endometrioid Cancer, G2 patients can also be included after evaluation and full knowledge; ③ Imaging examination confirmed that the tumor is confined to the endometrium, and patients with superficial myometrial invasion can also be included after evaluation and full knowledge; ④ No progesterone treatment and pregnancy contraindications ⑤Assess fertility function before treatment, no other fertility barrier factors; ⑥Sign informed consent and have good follow-up conditions.

[0045] 2. Condition...

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Abstract

The invention discloses an application of an ER and Ki-67 expression ratio in endometrial tissues in fertility function retention treatment prognosis of endometrial cancer (EC) and atypical endometrial hyperplasia (AH). According to the invention, 53 EC patients and 68 AH patients orally take MPA or MA, then gonadotropin is combined to release a hormone agonist and/or a levoynorethindrone intrauterine sustained release system, the patients are divided into a recurrence group and a non-recurrence group according to whether recurrence occurs after complete remission, then ER, PR, P16, P53, PTEN, Ki-67 and the like are subjected to immunohistochemical analysis, and statistical analysis is carried out. Results show that the expression rate of the Ki-67 is of great significance in predicting recurrence after the EC and AH retention fertility function treatment, and the optimal critical value (3.55) of ER/Ki-67 can predict recurrence after the EC and AH retention fertility function treatment better than that of a single immunohistochemical marker. The method has an important application value.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of the expression ratio of ER and Ki-67 in endometrial tissue in the prognosis of endometrial cancer (EC) and endometrial atypical hyperplasia (AH) with fertility-preserving treatment. Background technique [0002] Studies have shown that EC may develop from precursor lesions, mainly AH, and 29% of untreated AH patients may develop cancer. The mainstay of treatment for AH and EC is surgery, however, many EC patients are diagnosed under the age of 44, so surgery is not the best option, especially for nulliparous women who wish to preserve uterine fertility. According to reports, the remission rate of EC patients receiving progestin-based conservative treatment is 50-80%, and the pregnancy rate is 25-30%, however, the recurrence rate is as high as 24-40%. Therefore, it has been the focus of clinical research to find out the factors of recurrence in EC patient...

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Application Information

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IPC IPC(8): G01N33/74G01N33/68G16H50/20
CPCG01N33/743G01N33/6875G01N33/6893G16H50/20G01N2800/7028G01N2800/52G01N2800/54G01N2800/36
Inventor 李立伟肖泽睿王益勤何翊娇王志启沈丹华王建六
Owner PEOPLES HOSPITAL PEKING UNIV
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