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Application of traditional Chinese medicine composition in preparation of medicine for preventing cardiac rupture

A heart rupture and composition technology, applied in the field of pharmaceutical applications, can solve the problems of no recommended treatment method, unknown mechanism of action and main signaling pathway, and no breakthrough in protective measures

Pending Publication Date: 2022-06-07
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although studies have shown that the pharmaceutical composition of the present invention can reduce the myocardial no-reflow area after STEMI reperfusion, the mechanism of action and the main signaling pathway are unknown
In the past 30 years, the most prominent international progress is the discovery of a possible common pathway to protect myocardial ischemia-reperfusion injury in endothelial cells and cardiomyocytes, that is, reperfusion injury signaling (rescue) kinase (Reperfusion InjurySignaling (Salvage) ) Kinase, RISK) pathway, however, there is still no breakthrough in the study of protective measures, and so far there is no recommended treatment in the guidelines

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for preventing cardiac rupture
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing cardiac rupture
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing cardiac rupture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] a) The API formula is:

[0078] 39.6g of ginseng, 72.6g of leeches, 46.2g of earth turtles, 13.2g of frankincense, 33g of red peony, 13.2g of fragrant incense, 13.2g of sandalwood, 19.8g of whole scorpions, 46.2g of cicada sloughs, 6.6g of centipedes, 33g of borneol, 33g of fried jujube seeds;

[0079] b) Crushing process of medicinal materials:

[0080] The frankincense made from the five kinds of insect medicines of whole scorpion, leech, centipede, soil soft-shelled worm and cicada slough that have been cleaned, washed with water and processed according to the prescription are pulverized by a pulverizer, and the fineness of the powder reaches 80 mesh or more; The powdered medicinal powder is subjected to ultra-fine pulverization by various ultra-fine pulverizing techniques, so that the average particle size of the medicinal powder is less than 30 µm; the medicinal materials to be pulverized are washed, dried and sterilized before the ingredients;

[0081] c) Extract...

Embodiment 2

[0087] a) The API formula is:

[0088] Ginseng 59.4g Leech 52.8g Turmeric 46.2g Frankincense 13.2g

[0089] Red Peony 33g Fragrance 13.2g Sandalwood 13.2g Whole Scorpion 39.6g

[0090] Cicada Slough 46.2g Centipede 6.6g Borneol 33g Fried Sour Jujube Seed 33g

[0091] b) Crushing process of medicinal materials:

[0092] The frankincense made from the five kinds of insect medicines of whole scorpion, leech, centipede, soil soft-shelled worm and cicada slough that have been cleaned, washed with water and processed according to the prescription are pulverized by a pulverizer, and the fineness of the powder reaches 80 mesh or more; The powdered medicinal powder is subjected to ultra-fine pulverization by various ultra-fine pulverizing techniques, so that the average particle size of the medicinal powder is less than 70 µm; the medicinal materials to be pulverized are cleaned, dried and sterilized, and then the ingredients are prepared;

[0093] c) Extraction concentration and dr...

Embodiment 3

[0098] Example 3: Preparation of pills

[0099] a) The API formula is:

[0100] Ginseng 39.6g Leech 66g Turmeric 46.2g Frankincense 13.2g

[0101] Red Peony 33g Fragrance 13.2g Sandalwood 13.2g Whole Scorpion 46.2g

[0102] Cicada Slough 46.2g Centipede 6.6g Borneol 33g Fried Sour Jujube Seed 33g

[0103] b) Crushing process of medicinal materials:

[0104] The frankincense made from the whole scorpion, the leech, the centipede, the soil soft-shelled insect and the cicada slough that have been cleaned, washed and processed according to the prescription ingredients are pulverized by a pulverizer, and the fineness of the powder reaches 80 mesh or more; The powdered medicinal powder is ultra-finely pulverized by various ultra-fine pulverization techniques, so that the average particle size of the medicinal powder is 10 µm; the medicinal materials to be pulverized are washed, dried and sterilized, and then the ingredients are prepared;

[0105] c) Extraction concentration and ...

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Abstract

The invention provides application of a traditional Chinese medicine composition in preparation of a medicine for preventing cardiac rupture, the traditional Chinese medicine composition is composed of ginseng, leech, ground beetle, prepared frankincense, red peony root and other traditional Chinese medicines, and clinical experiments prove that the traditional Chinese medicine composition has a remarkable clinical curative effect on prevention of cardiac rupture.

Description

technical field [0001] The invention belongs to the field of pharmaceutical application, in particular to the use of a traditional Chinese medicine composition. Background technique [0002] Heart rupture is mostly caused by sharp knives, bullets, shrapnel, etc. penetrating the chest wall and injuring the heart, and a few are caused by violent impact on the chest. During myocardial infarction, the myocardium softens and the heart ruptures under the impact of blood flow, which is one of the important complications of myocardial infarction. Rupture of the right ventricle is the most common, followed by the left ventricle and the right atrium, and the rupture of the large vessels in the left atrium and the pericardium is rare. The incidence of acute myocardial infarction increases with age. In men, the peak incidence is 51 to 60 years old and in women 61 to 70 years old. Between the ages of 35 and 55, the risk of myocardial infarction in men is 6 times that of women. In old...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K9/48A61P9/00A61P9/10A61K35/62A61K35/64A61K35/646A61K35/648A61K31/045
CPCA61K36/258A61K35/62A61K35/64A61K36/324A61K36/71A61K36/65A61K36/48A61K36/185A61K35/646A61K35/648A61K31/045A61K36/725A61K9/48A61P9/00A61P9/10A61K2236/331A61K2236/51A61K2236/33A61K2236/39A61K2300/00Y02A50/30
Inventor 徐登峰吴盼盼宋灵杰邹广平
Owner SHIJIAZHUANG YILING PHARMA
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