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Application of wood essential oil in preparation of drugs or health products for treating brain cancer

A woody essential oil and application technology, applied in the field of medicine, can solve the problems of treating or preventing brain cancer with woody essential oil that have not been reported in the literature, and achieve the effects of toxicological safety, reduced toxicity, long half-life, and good fat solubility

Pending Publication Date: 2022-06-28
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no literature report that woody essential oil has the effect of treating or preventing brain cancer.

Method used

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  • Application of wood essential oil in preparation of drugs or health products for treating brain cancer
  • Application of wood essential oil in preparation of drugs or health products for treating brain cancer
  • Application of wood essential oil in preparation of drugs or health products for treating brain cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Collected from Lijiang City, Yunnan Province, and dried in the shade, the obtained dried spruce root was pulverized with a water-cooled speed-increasing high-efficiency flowing water pulverizer, and then passed through the No. 3 sieve of the pharmacopoeia standard sieve to obtain the pulverized yunmu incense. Sample; put 1kg of pulverized yunmu incense powder in a 10L round-bottomed flask, soak for 0.1h, add 7L of water, shake and mix well, reflux for extraction, and the extraction time is 3h; collect the reflux liquid, use ethyl acetate Ester extraction was performed three times, followed by drying with anhydrous sodium sulfate to remove water to obtain spruce essential oil with a yield of 0.20%.

Embodiment 2

[0024] Collected from Lijiang City, Yunnan Province, and dried in the shade, the obtained dried spruce root was pulverized with a water-cooled speed-increasing high-efficiency flowing water pulverizer, and then passed through the No. 3 sieve of the pharmacopoeia standard sieve to obtain the pulverized yunmu incense. Sample; place 1kg of pulverized yunmu incense powder in a 10L round-bottom flask, soak for 1h, add 7L of water, shake and mix well, reflux for extraction, and the extraction time is 5h; collect the reflux liquid, use ethyl acetate Extracted for 3 times, and then dried with anhydrous sodium sulfate to remove water to obtain spruce essential oil with a yield of 0.25%.

Embodiment 3

[0026] Collected from Lijiang City, Yunnan Province, and dried in the shade, the obtained dried spruce root was pulverized with a water-cooled speed-increasing high-efficiency flowing water pulverizer, and then passed through the No. 3 sieve of the pharmacopoeia standard sieve to obtain the pulverized yunmu incense. Sample: Place 1kg of pulverized yunmu incense powder in a 10L round-bottomed flask, soak for 2h, add 7L of water, shake and mix well, reflux for extraction, and extract for 7h; collect the reflux liquid, use ethyl acetate Extracted for 3 times, then dried with anhydrous sodium sulfate to remove water to obtain spruce essential oil with a yield of 0.26%.

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Abstract

The invention discloses an application of woodwood essential oil, namely an application of traditional Chinese medicine woodwood essential oil in preparation of drugs or health products for treating brain cancer. The application of the traditional Chinese medicine costus root essential oil in preparation of drugs or health products for treating brain cancer is attributed to the effect of the costus root essential oil for remarkably inhibiting human brain tumor cancer cells and neuromother tumor cancer cells, IC50 is 9.4 + / -0.51 mg / mL and 28.46 + / -2.57 mg / mL respectively, and the application is completely different from the application of the existing drugs or health products of the costus root essential oil. Compared with the current medicines and health products for treating brain cancer, the radix aucklandiae traditional Chinese medicine essential oil has the effects of inhibiting human brain tumor cells and neuromother tumor cells, has good fat solubility, and can easily pass through a blood brain barrier, so that the radix aucklandiae traditional Chinese medicine essential oil has the effects of improving or improving toxicological safety, improving or improving metabolic stability and preventing and treating brain cancer. The half-life period is longer; and the side effect is smaller.

Description

Technical field [0001] The present invention relates to the field of medicine, and in particular to the use of a woody essential oil in the preparation of drugs or health products for treating brain cancer. Background technique [0002] Intracranial tumors, also known as brain tumors or brain cancer, are one of the most common diseases of the central nervous system. Although brain cancer accounts for only 2% of all types of cancer, it is well known that it is extremely difficult to treat. Among them, brain cancer is divided into primary tumors that occur in brain tissue, meninges, cranial nerves, pituitary gland, blood vessels and residual embryonic tissue, and secondary tumors that metastasize from malignant tumors in other parts of the body or invade the brain. kind. At present, the main treatments for brain cancer are a combination of surgery, radiotherapy or chemotherapy, but the prognosis and survival rate of patients with this malignant tumor after treatment are stil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/285A61K8/92A23L33/105A61P35/00A61Q19/00
CPCA61K36/285A61K8/922A61Q19/00A61P35/00A23L33/105A23V2002/00A61K2800/10A23V2200/308A23V2250/21
Inventor 许敏伍俊琪王运芬陈浩冯阳
Owner KUNMING UNIV OF SCI & TECH
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