Application of JTE-013 in preparation of medicine for protecting glaucoma optic nerve injury

A technology for optic nerve injury and glaucoma, which is applied in the field of biomedicine and can solve problems such as poor specificity and disease deterioration.

Pending Publication Date: 2022-07-29
ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

"Fingolimod" and "Sinimod" have been approved by the FDA for the treatment of multiple sclerosis with typical manifestations of inflammato...

Method used

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  • Application of JTE-013 in preparation of medicine for protecting glaucoma optic nerve injury
  • Application of JTE-013 in preparation of medicine for protecting glaucoma optic nerve injury
  • Application of JTE-013 in preparation of medicine for protecting glaucoma optic nerve injury

Examples

Experimental program
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Effect test

Embodiment 1

[0023] 1. Drug preparation: Purchase drug JTE-013 (Tocris, CatNo.2392), according to the instructions, dissolve the powder in DMSO to make a 100mM stock solution, store it in a -80°C refrigerator, and dilute it with PBS to a working solution of the required concentration. , now with the current use. Pre-experimental exploration was carried out with JTE-013 at concentrations of 100 μM, 300 μM, 900 μM, 1800 μM and 2700 μM, respectively, and it was found that the concentration of 900 μM had the best optic nerve protection effect.

[0024] 2. Intravitreal injection:

[0025] (1) 5-8 week old male C57 / B6J mice were purchased and reared adaptively for 7 days to start the experiment. The left eye was the experimental eye, and the right eye was the parallel control eye. Divided into 3 large groups, each large group of 5 groups, each group of 10. Including: normal control group (Control, Ctrl in the figure), I / R modeling group (I / R+PBS, I / R+PBS or PBS in the figure), I / R+JTE-013 tre...

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Abstract

The invention discloses an application of JTE-013 in preparation of a medicine for protecting glaucoma optic nerve injury. According to the application, the JTE-013 is applied to treatment of an ischemia reperfusion model of a glaucoma related animal model for the first time, the treatment effect of the JTE-013 is determined, and the JTE-013 can obviously improve retinal ganglion cell injury caused by increase of intraocular pressure; axonal injury caused by increase of intraocular pressure can be obviously improved; the activation of microglial cells can be obviously inhibited; myelin sheath regeneration and proliferation of myelin sheath formation cell oligodendroglia cells can be obviously promoted; the visual function can be obviously recovered.

Description

Technical field: [0001] The invention belongs to the field of biomedicine, and particularly relates to the application of JTE-013 in the preparation of a medicine for protecting glaucoma optic nerve damage. Background technique: [0002] Glaucoma is a neurodegenerative disease characterized by progressive damage to retinal ganglion cells (RGCs) and their axons. Typical clinical manifestations include optic nerve atrophy, visual field defects, and decreased visual acuity. Although the pathological mechanism of glaucoma is widely studied, it is still not fully understood. At present, lowering intraocular pressure is still considered to be the only effective way to treat glaucoma, but lowering intraocular pressure by drugs or surgery cannot reverse optic nerve damage and restore visual function. How to effectively protect RGCs and promote axonal regeneration and functional recovery is the focus of basic research. Studies have shown that demyelination usually occurs after axon...

Claims

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Application Information

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IPC IPC(8): A61K31/444A61P27/06A61P25/00A61P27/02
CPCA61K31/444A61P27/06A61P25/00A61P27/02
Inventor 卓业鸿李轶擎薛京菲刘哲林记城
Owner ZHONGSHAN OPHTHALMIC CENT SUN YAT SEN UNIV
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