4 results about "Increased Ocular Pressure" patented technology

The present disclosure pertains to the field of animal disease models, specifically to a method for constructing an animal model of open-angle glaucoma. In this model, the pathogenesis of open-angle glaucoma is mimicked by inducing necroptosis in trabecular meshwork cells through the injection of IFN-γ into the anterior chamber. This process leads to the inhibition of trabecular meshwork activity and functional impairment, resulting in elevated intraocular pressure and subsequent optic nerve changes indicative of glaucoma. The pathophysiological alterations observed in the animal model closely resemble those seen in human open-angle glaucoma, including chamber angle opening, trabecular meshwork dysfunction, increased intraocular pressure, and loss of RGCs.

The present disclosure pertains to the phakic refractive lenses such as toric lenses, an advanced posterior chamber floating phakic refractive lens (PRL) designed for the correction of severe refractive errors, including myopia, hyperopia, and astigmatism. This innovative lens can reduce or minimize complications commonly associated with traditional phakic intraocular lenses, such as intraocular pressure elevation, cataract formation, and iris pigment dispersion. The phakic refractive lenses such as the toric lenses described herein feature a buoyant, flexible structure with a central aperture to facilitate aqueous humor flow, creating a natural centering force that stabilizes the lens within the pupillary space.

The application discloses a teaching simulative human eyeball aqueous humor circulation model in the technical field of eyeball aqueous humor circulation models, which comprises a model box, an eyeball model assembly arranged in the model box, a functional body arranged at the top of the model box and a pump assembly arranged in the functional body. The eyeball model assembly comprises an eyeball wall, an eyeball and an optic nerve, and the eyeball wall is provided with a cornea at the front end. An iris is arranged on the side of the cornea close to the eyeball, the space between the cornea and the iris is an anterior chamber, the included angle between the cornea and the iris is an anterior chamber angle, the center of the iris is provided with a pupil, the iris is provided with a lens on the side close to the eyeball, the lens is provided with a zonular ligament around the lens, and the other end of the zonular ligament is fixedly connected with a ciliary body. The space between the iris and the lens constitutes a posterior chamber. The application has the advantages of simple structure, simulation of the process that the aqueous humor is retained in the eye to press the optic nerve when the anterior chamber angle is closed or the aqueous humor outflow passage is blocked, and convenience for medical students to understand the process that the optic nerve is pressed by the increased intraocular pressure when the aqueous humor passage is blocked.

The invention provides application of kushenone in preparation of a product for preventing and / or treating glaucoma, and belongs to the technical field of biological medicine. According to the application disclosed by the invention, the kushenone has the effect of preventing and / or treating glaucoma for the first time, can be used as a candidate medicine for treating acute glaucoma, can prevent ischemia reperfusion injury caused by acute intraocular pressure rise, and has the effect of inhibiting ferroptosis so as to play a role in protecting retinal ganglion cells; an effect can be achieved by inhibiting a cGAS-STING pathway and LCN2 expression, so that ferroptosis of microglial cells is inhibited.