31 results about "Increased Ocular Pressure" patented technology

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

A drainage apparatus is disclosed to reduce intraocular pressure in an eyeball that includes an anterior chamber having aqueous humor disposed therein, a cornea and a surrounding marginal limbus by which the cornea is continuous with a scleral layer and a conjunctival layer disposed on an exposed surface of the eyeball and under eyelids, the apparatus comprising an inlet assembly configured to be disposed at the anterior chamber of the eyeball, an outlet assembly configured to be disposed at the external surface of the eyeball, the assembly having a central chamber, a tube extending between the inlet and outlet assemblies and configured to promote fluid communication between the inlet and outlet assemblies, and control means disposed within the outlet assembly for controlling a flow of aqueous humor through the tube from the anterior chamber of the eyeball to the external surface of the eyeball, the control means further comprising a replaceable filter disposed within the central chamber of the outer member to prevent intraocular infection, the filter having a medicinal agent applied thereto for preventing occlusion of the filter or bacterial contamination by inhibiting at least one of the formation of fibrotic membranes, inflammatory membrane, or bacterial adhesions or biofilms, thereby preventing increased of intraocular pressure or infection.

The invention relates to a high cohesion double crosslinking artificial glass body and a preparation method thereof. A hydrogel is prepared from a first solution and a second solution. A first component contained in the first solution is aldehyde hyaluronic acid, and a second component contained in the second solution is aminated hyaluronic acid. The preparation method comprises the step of blending the first solution and the second solution. The high cohesion double crosslinking artificial glass body can be gelled in situ in an empty glass body cavity by injection to effectively jack and press retinas, has no toxic side effects, good biocompatibility and cohesion, cannot cause an intraocular inflammatory reaction and the rising of intraocular pressure, does not need to be taken out twice,and degrades slowly in eyes, and the spare position is replaced and supplemented by aqueous humors; and in addition, the retinas of local detachment are restored through adhesive attraction.

The invention discloses a gel and a preparation method thereof, belonging to the field of tissue material engineering. The gel is prepared from active substances including the following three components: Among them, the first component is N-hydroxysuccinimide-glutarate-modified PEG, and the second component is polymer Lysine, the third component is a thickener; wherein, the active substance does not include amino-modified polyethylene glycol and amino-modified polyethylene oxide derivatives. The swelling performance of the gel of the present invention can maintain low swelling and low shrinkage in the range of up to 180 days, which is very important for ophthalmic use, because a high swelling rate of the vitreous substitute will cause glaucoma due to increased intraocular pressure , If the fundus gel has a high swelling rate, it will pull the retina and cause retinal detachment.

The present invention relates to compositions for the treatment of glaucoma and elevated intraocular pressure. The composition comprises nitric oxide releasing isomannitol derivatives and prostaglandin F 2α analog.

A glaucoma aqueous humor drainage device and a glaucoma aqueous humor drainage method, the switch of the valve is controlled by the change of the cavity pressure in the pressure valve, when the intraocular pressure exceeds 12mmHg, the valve is opened, and the valve is connected with drainage The tube drains the aqueous humor to the ocular surface, and relieves the patient's discomfort and dry eyes. It can effectively drain the aqueous humor and avoid scarring caused by the conjunctival flap embedding device and the generation of filtering blebs that lead to increased intraocular pressure and cause surgical failure. .