30 results about "Increased Ocular Pressure" patented technology

Because vision loss in most forms of glaucoma is related to elevated IOP, most glaucoma treatment protocols are concerned with lowering IOP by increasing aqueous humor outflow. The invention utilizes electromagnetic radiation to create retraction in the iris tissue, thereby (a) reducing convexity and enlarging the drainage angle and thus the area of the anterior chamber, (b) reducing contact between the zonule fibers and the iris pigment epithelium, (c) applying greater tension to both the TM and uveoscleral outflow pathways, thereby enlarging those pathways and increasing outflow.

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

Inhibition of geranylgeranylation of Rho GTPases and heterotrimeric G-proteins in the aqueous outflow pathway increases aqueous humor outflow, possibly through the tissue relaxation, and through altered cell adhesive interactions and actin cytoskeletal organization in cells of the outflow pathway. In addition, such inhibition is useful for treating age-related macular degeneration. The GGTase-I enzyme is a molecular target for lowering increased ocular pressure in glaucoma patients.

A drainage apparatus is disclosed to reduce intraocular pressure in an eyeball that includes an anterior chamber having aqueous humor disposed therein, a cornea and a surrounding marginal limbus by which the cornea is continuous with a scleral layer and a conjunctival layer disposed on an exposed surface of the eyeball and under eyelids, the apparatus comprising an inlet assembly configured to be disposed at the anterior chamber of the eyeball, an outlet assembly configured to be disposed at the external surface of the eyeball, the assembly having a central chamber, a tube extending between the inlet and outlet assemblies and configured to promote fluid communication between the inlet and outlet assemblies, and control means disposed within the outlet assembly for controlling a flow of aqueous humor through the tube from the anterior chamber of the eyeball to the external surface of the eyeball, the control means further comprising a replaceable filter disposed within the central chamber of the outer member to prevent intraocular infection, the filter having a medicinal agent applied thereto for preventing occlusion of the filter or bacterial contamination by inhibiting at least one of the formation of fibrotic membranes, inflammatory membrane, or bacterial adhesions or biofilms, thereby preventing increased of intraocular pressure or infection.

The invention relates to a high cohesion double crosslinking artificial glass body and a preparation method thereof. A hydrogel is prepared from a first solution and a second solution. A first component contained in the first solution is aldehyde hyaluronic acid, and a second component contained in the second solution is aminated hyaluronic acid. The preparation method comprises the step of blending the first solution and the second solution. The high cohesion double crosslinking artificial glass body can be gelled in situ in an empty glass body cavity by injection to effectively jack and press retinas, has no toxic side effects, good biocompatibility and cohesion, cannot cause an intraocular inflammatory reaction and the rising of intraocular pressure, does not need to be taken out twice,and degrades slowly in eyes, and the spare position is replaced and supplemented by aqueous humors; and in addition, the retinas of local detachment are restored through adhesive attraction.

The invention discloses a multifunctional bed for post-vitrectomy rehabilitation. The multifunctional bed comprises bed frame and a bed body, wherein the bed body is horizontally arranged on the bed frame, is used for supporting a human body and is formed by sequentially arranging a height-adjustable headrest supporting part, a fixed body supporting part and dip-angle-adjustable lower limb supporting part from a bedside end to a bed tail end, and a pair of front face clamping-supporting parts are formed in the middle of the headrest supporting part at intervals along the length direction of the bed frame. The multifunctional bed has the advantages that the structure is simple, the operation is simple and convenient, and different forced postures can be easily switched. The easy switching between two postures, namely a prostrate posture and a sitting posture of a post-vitrectomy patient is realized, so that the smooth breathing of the patient is guaranteed, untoward effects of dizziness, chest distress, neck muscle fatigue and ache, limb numbness, face edema, skin pressure sores, increase of intraocular pressure and the like caused to long-term maintenance of the patient are avoided, and the comfort level of the patient is increased; and the patient can maintain a face-down forced posture for a long time, thereby benefiting postoperative rehabilitation.

A viscoelastic medium is useful for the manufacture of a medicament, such as a medical device, for treatment of increased intraocular pressure in the eye of a human or animal. The medicament is administerable into at least one sclerally penetrating fistula of the eye such that the fistula is filled with the medicament. The medium is also useful in a method of treating increased intraocular pressure in the eye of a human or an animal in need thereof, comprising the step of injecting the viscoelastic medium into at least one sclerally penetrating fistula in the eye such that the fistula is filled with the medium.

The invention discloses a gel and a preparation method thereof, belonging to the field of tissue material engineering. The gel is prepared from active substances including the following three components: Among them, the first component is N-hydroxysuccinimide-glutarate-modified PEG, and the second component is polymer Lysine, the third component is a thickener; wherein, the active substance does not include amino-modified polyethylene glycol and amino-modified polyethylene oxide derivatives. The swelling performance of the gel of the present invention can maintain low swelling and low shrinkage in the range of up to 180 days, which is very important for ophthalmic use, because a high swelling rate of the vitreous substitute will cause glaucoma due to increased intraocular pressure , If the fundus gel has a high swelling rate, it will pull the retina and cause retinal detachment.

Inhibition of geranylgeranylation of Rho GTPases and heterotrimeric G-proteins in the aqueous outflow pathway increases aqueous humor outflow, possibly through the tissue relaxation, and through altered cell adhesive interactions and actin cytoskeletal organization in cells of the outflow pathway. In addition, such inhibition is useful for treating age-related macular degeneration. The GGTase-I enzyme is a molecular target for lowering increased ocular pressure in glaucoma patients.

A glaucoma aqueous humor drainage device and a glaucoma aqueous humor drainage method, wherein the opening and closing of a pressure valve is controlled by the change in the pressure in a cavity of the valve. When the pressure in the intraocular pressure exceeds 12 mmHg, the valve is opened, and a drainage tube connected behind the valve drains the aqueous humor to the ocular surface, reducing the patient's discomfort and dry eyes, effectively draining the aqueous humor and avoiding scarring caused by embedding the device via a conjunctival flap and operation failure caused by increase of intraocular pressure caused by generation of filtering blebs.

The object of the present invention is to find a new application of isopropyl (6-{ [4-(pyrazol-1-yl)benzyl] (pyridin-3-ylsulfonyl)aminomethyl}pyridin-2-ylamino)acetate or a salt thereof. Isopropyl (6-{ [4-(pyrazol-1-yl)benzyl] (pyridin-3-ylsulfonyl) aminometh yl}pyridin-2-ylamino) acetate or a salt thereof is useful as a therapeutic agent for a disease involving a greatly elevated intraocular pressure.

The present invention relates to compositions for the treatment of glaucoma and elevated intraocular pressure. The composition comprises nitric oxide releasing isomannitol derivatives and prostaglandin F 2α analog.

A glaucoma aqueous humor drainage device and a glaucoma aqueous humor drainage method, the switch of the valve is controlled by the change of the cavity pressure in the pressure valve, when the intraocular pressure exceeds 12mmHg, the valve is opened, and the valve is connected with drainage The tube drains the aqueous humor to the ocular surface, and relieves the patient's discomfort and dry eyes. It can effectively drain the aqueous humor and avoid scarring caused by the conjunctival flap embedding device and the generation of filtering blebs that lead to increased intraocular pressure and cause surgical failure. .

The invention discloses influence of WS6 on actin formation of trabecular meshwork cells. WS6 refers to anti-diabetic medicine glibenclamide, sodium orthovanadate and an active compound capable of promoting pancreatic beta cell proliferation. WS6 has cytotoxicity on the trabecular meshwork cells and inhibits actin formation of the trabecular meshwork cells. The influence of WS6 has the beneficialeffect that the fact that WS6 can remarkably inhibit actin formation, caused by TRPV4 agonist GSK101, of the trabecular meshwork cells is revealed. Intraocular pressure can be reduced, and the influence of WS6 has potential treatment significance in glaucoma caused by increase of intraocular pressure.

An improved self-centering phakic refractive lens is disclosed. The lens floats freely in the posterior chamber of the eye and corrects vision of the patient but also prevents buildup of intraocular pressure, cataract induction and iris pigment dispersion. The lens comprises an optical body, haptic members which extend outward from the optical body, and a small hole in the approximate center of the optical body for the purpose of allowing aqueous humor to flow through that hole. The lens is designed such that its posterior surface conforms to the shape of the anterior surface of the patient's natural crystalline lens.

A glaucoma aqueous humor drainage device and a glaucoma aqueous humor drainage method, wherein the opening and closing of a pressure valve is controlled by the change in the pressure in a cavity of the valve. When the pressure in the intraocular pressure exceeds 12 mmHg, the valve is opened, and a drainage tube connected behind the valve drains the aqueous humor to the ocular surface, reducing the patient's discomfort and dry eyes, effectively draining the aqueous humor and avoiding scarring caused by embedding the device via a conjunctival flap and operation failure caused by increase of intraocular pressure caused by generation of filtering blebs.